Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine

Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

(2021) Pritesh Desai et al.   CELL

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

(2021) Elisabeth E. L. Nyström et al.   SCIENCE

Clump sequencing exposes the spatial expression programs of intestinal secretory cells

(2021) Rita Manco et al.   Nature Communications

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

(2020) John W. McGinty et al.   IMMUNITY

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche

(2020) Manolis Roulis et al.   NATURE

Cell fate specification and differentiation in the adult mammalian intestine

(2020) Joep Beumer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

(2020) Kirk Bergstrom et al.   SCIENCE

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3

(2019) Pingping Zhu et al.   NATURE IMMUNOLOGY

Infection by the parasitic helminthTrichinella spiralisactivates a Tas2r-mediated signaling pathway in intestinal tuft cells

(2019) Xiao-Cui Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus

(2019) James Meixiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of the prostaglandin D 2 receptor 2 and its downstream effects on the pathophysiology of asthma

(2019) Christopher E. Brightling et al.   ALLERGY

Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis

(2019) Zhen Xiong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour

(2019) Bernd Bufe et al.   Nature Communications

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

(2018) Christoph Schneider et al.   CELL

Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection

(2018) Monica Macal et al.   IMMUNITY

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

(2018) Weiwei Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

(2018) Andreas E. Moor et al.   CELL

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

(2018) Corey N. Miller et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

(2018) Elisabeth Weiß et al.   TRENDS IN IMMUNOLOGY

Tuft Cells—Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry

(2018) Claire E. O'Leary et al.   Annual Review of Immunology

Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells

(2018) Jessica Wei et al.   TRENDS IN BIOCHEMICAL SCIENCES

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB

(2017) Simon N. Willis et al.   Nature Communications

Allograft inflammatory factor 1 is a regulator of transcytosis in M cells

(2017) Sari Kishikawa et al.   Nature Communications

Preservation of three-dimensional spatial structure in the gut microbiome

(2017) Yuko Hasegawa et al.   PLoS One

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

(2016) Ryu Okumura et al.   NATURE

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Chemosensory Receptor Specificity and Regulation

(2015) Ryan P. Dalton et al.   Annual Review of Neuroscience

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Long-lived intestinal tuft cells serve as colon cancer–initiating cells

(2014) C. Benedikt Westphalen et al.   JOURNAL OF CLINICAL INVESTIGATION

SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity

(2014) Matthew A. Care et al.   NUCLEIC ACIDS RESEARCH

Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches

(2013) Anna Ermund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

Molecular organization of vomeronasal chemoreception

(2011) Yoh Isogai et al.   NATURE

Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

(2009) Stéphane Rivière et al.   NATURE

Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells

(2008) C. Bezençon et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Evaluating cell-surface expression and measuring activation of mammalian odorant receptors in heterologous cells

(2008) Hanyi Zhuang et al.   Nature Protocols