The role of the microbiota-gut-brain axis in neuropsychiatric disorders

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

(2019) Peng Zheng et al.   Science Advances

Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study

(2019) H.X. Chong et al.   Beneficial Microbes

Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers

(2019) Nielson T. Baxter et al.   mBio

Fecal microbiota transplantation in an elderly patient with mental depression

(2019) Ting Cai et al.   INTERNATIONAL PSYCHOGERIATRICS

Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients

(2019) Amir Ghaderi et al.   BMC Psychiatry

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

(2019) Liu et al.   Nutrients

Infection-Induced Systemic Inflammation Is a Potential Driver of Alzheimer's Disease Progression

(2019) Vijayasree V. Giridharan et al.   Frontiers in Aging Neuroscience

Dysbiosis of gut microbiota in a selected population of Parkinson's patients

(2019) Daniele Pietrucci et al.   PARKINSONISM & RELATED DISORDERS

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota

(2019) Dae-Wook Kang et al.   Scientific Reports

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Neurobiology and Therapeutic Potential of Cyclooxygenase-2 (COX-2) Inhibitors for Inflammation in Neuropsychiatric Disorders

(2019) Rickinder Sethi et al.   Frontiers in Psychiatry

Prenatal low-dose penicillin results in long-term sex-specific changes to murine behaviour, immune regulation, and gut microbiota

(2019) Kevin Champagne-Jorgensen et al.   BRAIN BEHAVIOR AND IMMUNITY

Butyrate suppresses demyelination and enhances remyelination

(2019) Tong Chen et al.   Journal of Neuroinflammation

Resolution of neuroinflammation: mechanisms and potential therapeutic option

(2019) Nikolaos Dokalis et al.   Seminars in Immunopathology

Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions

(2019) Maria Vittoria Ristori et al.   Nutrients

Incidence of Clostridium perfringens and its toxin genes in the gut of children with autism spectrum disorder

(2019) Maryam K. Alshammari et al.   ANAEROBE

A Descriptive Review on the Prevalence of Gastrointestinal Disturbances and Their Multiple Associations in Autism Spectrum Disorder

(2019) Radu Lefter et al.   Medicina-Lithuania

The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism

(2019) Yijing Yu et al.   Journal of Clinical Medicine

Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial

(2018) Faith Dickerson et al.   BIPOLAR DISORDERS

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial

(2018) Asma Kazemi et al.   CLINICAL NUTRITION

Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled trial

(2018) Omid Reza Tamtaji et al.   CLINICAL NUTRITION

Efficacy of probiotics on anxiety-A meta-analysis of randomized controlled trials

(2018) Bangshan Liu et al.   DEPRESSION AND ANXIETY

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer’s disease in wild-type, C57BL/6 mice

(2018) Luisa Torres et al.   Journal of Neuroinflammation

Maternal immune activation induced by lipopolysaccharide triggers immune response in pregnant mother and fetus, and induces behavioral impairment in adult rats

(2018) Lutiana Roque Simões et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Investigation of probiotics in multiple sclerosis

(2018) Stephanie K Tankou et al.   Multiple Sclerosis Journal

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

Investigation of probiotics in multiple sclerosis

(2018) Stephanie K Tankou et al.   Multiple Sclerosis Journal

The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis

(2018) Bruno Bonaz et al.   Frontiers in Neuroscience

Probiotic Supplementation in Patients with Alzheimer’s Dementia – An Explorative Intervention Study

(2018) Friedrich Leblhuber et al.   Current Alzheimer Research

Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women

(2018) S. Mörkl et al.   EUROPEAN JOURNAL OF NUTRITION

Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects

(2018) Tanya T. Nguyen et al.   SCHIZOPHRENIA RESEARCH

Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration

(2018) Minqing Gu et al.   Nutrients

A prebiotic intervention study in children with autism spectrum disorders (ASDs)

(2018) Roberta Grimaldi et al.   Microbiome

Probiotic and selenium co-supplementation, and the effects on clinical, metabolic and genetic status in Alzheimer's disease: A randomized, double-blind, controlled trial

(2018) Omid Reza Tamtaji et al.   CLINICAL NUTRITION

Microbiome–microglia connections via the gut–brain axis

(2018) Reem Abdel-Haq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations

(2018) Francisca Taciana Sousa Rodrigues et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Probiotic Treatment in Individuals with Euthymic Bipolar Disorder: A Pilot-Study on Clinical Changes and Compliance

(2018) Eva Z. Reininghaus et al.   NEUROPSYCHOBIOLOGY

Effect of bifidobacterium breve A-1 on anxiety and depressive symptoms in schizophrenia: A proof-of-concept study

(2018) Ryo Okubo et al.   JOURNAL OF AFFECTIVE DISORDERS

The gut microbiome composition associates with bipolar disorder and illness severity

(2017) Simon J. Evans et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

(2017) Glenn R. Gibson et al.   Nature Reviews Gastroenterology & Hepatology

Vagotomy and Parkinson disease

(2017) Bojing Liu et al.   NEUROLOGY

Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health

(2017) Alison M. Stephen et al.   NUTRITION RESEARCH REVIEWS

The association between immune markers and recent suicide attempts in patients with serious mental illness: A pilot study

(2017) Faith Dickerson et al.   PSYCHIATRY RESEARCH

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis

(2017) Ran Huo et al.   Frontiers in Cellular and Infection Microbiology

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study

(2017) Dae-Wook Kang et al.   Microbiome

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study

(2017) Vanessa D. de Mello et al.   Scientific Reports

Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring

(2016) Shelly A. Buffington et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

(2016) G B Rogers et al.   MOLECULAR PSYCHIATRY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?

(2016) Roman M. Stilling et al.   NEUROCHEMISTRY INTERNATIONAL

Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial

(2016) Ghodarz Akkasheh et al.   NUTRITION

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

(2016) Elmira Akbari et al.   Frontiers in Aging Neuroscience

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

(2016) A P Allen et al.   Translational Psychiatry

Association of Aryl Hydrocarbon Receptor-Related Gene Variants with the Severity of Autism Spectrum Disorders

(2016) Takashi X. Fujisawa et al.   Frontiers in Psychiatry

A significant causal association between C-reactive protein levels and schizophrenia

(2016) Masatoshi Inoshita et al.   Scientific Reports

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

Proteomic pathway analysis of the hippocampus in schizophrenia and bipolar affective disorder implicates 14-3-3 signaling, aryl hydrocarbon receptor signaling, and glucose metabolism: Potential roles in GABAergic interneuron pathology

(2015) Klaus Oliver Schubert et al.   SCHIZOPHRENIA RESEARCH

Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson’s Disease

(2015) Satoru Hasegawa et al.   PLoS One

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

(2014) Colin Hill et al.   Nature Reviews Gastroenterology & Hepatology

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Chronic treatment with valproic acid or sodium butyrate attenuates novel object recognition deficits and hippocampal dendritic spine loss in a mouse model of autism

(2014) Kazuhiro Takuma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Cytokine Alterations in Bipolar Disorder: A Meta-Analysis of 30 Studies

(2013) Amirhossein Modabbernia et al.   BIOLOGICAL PSYCHIATRY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Pathophysiology of neonatal acute bacterial meningitis

(2013) T. Barichello et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine

(2013) Helene M. Savignac et al.   NEUROCHEMISTRY INTERNATIONAL

Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods

(2013) R. Nishino et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Recognition of bacterial infection by innate immune sensors

(2012) Sushil Kumar et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Current concepts on the pathogenesis of Escherichia coli meningitis

(2012) Kwang S. Kim   CURRENT OPINION IN INFECTIOUS DISEASES

The role of the gut microbiota in nutrition and health

(2012) Harry J. Flint et al.   Nature Reviews Gastroenterology & Hepatology

Behavioral and neurochemical effects of sodium butyrate in an animal model of mania

(2011) Morgana Moretti et al.   BEHAVIOURAL PHARMACOLOGY

Pathogenesis and Pathophysiology of Pneumococcal Meningitis

(2011) B. B. Mook-Kanamori et al.   CLINICAL MICROBIOLOGY REVIEWS

The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice

(2011) Premysl Bercik et al.   GASTROENTEROLOGY

Synergistic Effects of Sodium Butyrate, a Histone Deacetylase Inhibitor, on Increase of Neurogenesis Induced by Pyridoxine and Increase of Neural Proliferation in the Mouse Dentate Gyrus

(2011) Dae Young Yoo et al.   NEUROCHEMICAL RESEARCH

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Outbreak of Acute Bacterial Gastroenteritis Is Associated With an Increased Incidence of Irritable Bowel Syndrome in Children

(2010) Marroon Thabane et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

(2010) Alberto Serrano-Pozo et al.   BRAIN

Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects

(2010) Michaël Messaoudi et al.   BRITISH JOURNAL OF NUTRITION

Streptococcus pneumoniae: virulence factors and variation

(2010) A.M. Mitchell et al.   CLINICAL MICROBIOLOGY AND INFECTION

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

(2010) L. Desbonnet et al.   NEUROSCIENCE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain

(2009) Hyeon Ju Kim et al.   JOURNAL OF NEUROCHEMISTRY

The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection

(2008) Elena F. Verdu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA