Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges
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Title
Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges
Authors
Keywords
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Journal
Advanced Healthcare Materials
Volume 7, Issue 2, Pages 1701000
Publisher
Wiley
Online
2017-12-05
DOI
10.1002/adhm.201701000
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Note: Only part of the references are listed.- Self-contained, low-cost Body-on-a-Chip systems for drug development
- (2017) Ying I Wang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Organ-on-a-chip devices advance to market
- (2017) Boyang Zhang et al. LAB ON A CHIP
- A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control
- (2017) J. R. Coppeta et al. LAB ON A CHIP
- Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
- (2017) Yu Shrike Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advances in engineering hydrogels
- (2017) Yu Shrike Zhang et al. SCIENCE
- Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes
- (2017) Sebastiaan J. Trietsch et al. Nature Communications
- Generation of a co-culture cell micropattern model to simulate lung cancer bone metastasis for anti-cancer drug evaluation
- (2017) Huixiang Zhong et al. RSC Advances
- Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro
- (2017) Ken-ichiro Kamei et al. RSC Advances
- Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
- (2017) Lawrence Vernetti et al. Scientific Reports
- Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis
- (2016) Zhiyun Xu et al. ACS Applied Materials & Interfaces
- Tumor cell intravasation
- (2016) Serena P. H. Chiang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip
- (2016) Yu Shrike Zhang et al. BIOMATERIALS
- A microfluidic optical platform for real-time monitoring of pH and oxygen in microfluidic bioreactors and organ-on-chip devices
- (2016) Seyed Ali Mousavi Shaegh et al. Biomicrofluidics
- Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening
- (2016) Ying I. Wang et al. BIOTECHNOLOGY AND BIOENGINEERING
- Design and demonstration of a pumpless 14 compartment microphysiological system
- (2016) Paula G. Miller et al. BIOTECHNOLOGY AND BIOENGINEERING
- A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model
- (2016) Hyuna Lee et al. BIOTECHNOLOGY AND BIOENGINEERING
- Microtechnology-based organ systems and whole-body models for drug screening
- (2016) Seung Hwan Lee et al. Biotechnology Journal
- Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling
- (2016) Aleksander Skardal et al. DRUG DISCOVERY TODAY
- An on-chip model for investigating the interaction between neurons and cancer cells
- (2016) Yifeng Lei et al. Integrative Biology
- Drug delivery of the future: Chasing the invisible gorilla
- (2016) Kinam Park JOURNAL OF CONTROLLED RELEASE
- Innovation in the pharmaceutical industry: New estimates of R&D costs
- (2016) Joseph A. DiMasi et al. JOURNAL OF HEALTH ECONOMICS
- Implementing oxygen control in chip-based cell and tissue culture systems
- (2016) Pieter E. Oomen et al. LAB ON A CHIP
- Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue
- (2016) Mandy B. Esch et al. LAB ON A CHIP
- Drug Delivery Research: The Invention Cycle
- (2016) Kinam Park MOLECULAR PHARMACEUTICS
- In vivo studies of substances used in the cosmetic industry
- (2016) Joanna Igielska-Kalwat et al. Postepy Dermatologii i Alergologii
- A versatile lab-on-a-chip tool for modeling biological barriers
- (2016) Fruzsina R. Walter et al. SENSORS AND ACTUATORS B-CHEMICAL
- A Laminated Microfluidic Device for Comprehensive Preclinical Testing in the Drug ADME Process
- (2016) Fan An et al. Scientific Reports
- Microtechnology-based organ systems and whole-body models for drug screening
- (2016) Seung Hwan Lee et al. Biotechnology Journal
- Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units
- (2016) S. G. M. Uzel et al. Science Advances
- Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks
- (2016) Patrick M. Misun et al. Microsystems & Nanoengineering
- Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs
- (2016) Carlota Oleaga et al. Scientific Reports
- Engineered In Vitro Disease Models
- (2015) Kambez H. Benam et al. Annual Review of Pathology-Mechanisms of Disease
- A phenotypic in vitro model for the main determinants of human whole heart function
- (2015) Maria Stancescu et al. BIOMATERIALS
- Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
- (2015) Jacquelyn A. Brown et al. Biomicrofluidics
- Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models
- (2015) Thibault Bricks et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Morphological and functional characterization of human induced pluripotent stem cell-derived neurons (iCell Neurons) in defined culture systems
- (2015) Bonnie J. Berry et al. BIOTECHNOLOGY PROGRESS
- Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury
- (2015) M J Cross et al. BRITISH JOURNAL OF PHARMACOLOGY
- Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro
- (2015) Ilka Maschmeyer et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
- (2015) Hasan Erbil Abaci et al. Integrative Biology
- A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing
- (2015) Eva-Maria Materne et al. JOURNAL OF BIOTECHNOLOGY
- A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions
- (2015) E. E. Zahavi et al. JOURNAL OF CELL SCIENCE
- Adding the ‘heart’ to hanging drop networks for microphysiological multi-tissue experiments
- (2015) Saeed Rismani Yazdi et al. LAB ON A CHIP
- A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents
- (2015) Ilka Maschmeyer et al. LAB ON A CHIP
- Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow
- (2015) Mandy B. Esch et al. LAB ON A CHIP
- A microengineered pathophysiological model of early-stage breast cancer
- (2015) Yoonseok Choi et al. LAB ON A CHIP
- In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs
- (2015) Ayalew Tefferi et al. MAYO CLINIC PROCEEDINGS
- Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
- (2015) Sandra March et al. Nature Protocols
- An analysis of the attrition of drug candidates from four major pharmaceutical companies
- (2015) Michael J. Waring et al. NATURE REVIEWS DRUG DISCOVERY
- Central Nervous System and its Disease Models on a Chip
- (2015) YoonYoung Yi et al. TRENDS IN BIOTECHNOLOGY
- Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids
- (2015) Benjamin S. Freedman et al. Nature Communications
- Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology
- (2015) Jeremy D. Caplin et al. Advanced Healthcare Materials
- μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips
- (2015) Peter Loskill et al. PLoS One
- How multi-organ microdevices can help foster drug development
- (2014) Mandy B. Esch et al. ADVANCED DRUG DELIVERY REVIEWS
- Photodegradable Hydrogels for Capture, Detection, and Release of Live Cells
- (2014) Dong-Sik Shin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- 3D Biofabrication Strategies for Tissue Engineering and Regenerative Medicine
- (2014) Piyush Bajaj et al. Annual Review of Biomedical Engineering
- A phenotypic culture system for the molecular analysis of CNS myelination in the spinal cord
- (2014) Hedvika Davis et al. BIOMATERIALS
- A microfluidic model for organ-specific extravasation of circulating tumor cells
- (2014) R. Riahi et al. Biomicrofluidics
- First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans
- (2014) Jean Matthieu Prot et al. BIOTECHNOLOGY AND BIOENGINEERING
- Organs-on-a-chip: a new tool for drug discovery
- (2014) Alessandro Polini et al. Expert Opinion on Drug Discovery
- A multiplexed chip-based assay system for investigating the functional development of human skeletal myotubes in vitro
- (2014) A.S.T. Smith et al. JOURNAL OF BIOTECHNOLOGY
- Podosomes of dendritic cells facilitate antigen sampling
- (2014) M. V. Baranov et al. JOURNAL OF CELL SCIENCE
- Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
- (2014) Mandy B. Esch et al. LAB ON A CHIP
- Microfluidic organs-on-chips
- (2014) Sangeeta N Bhatia et al. NATURE BIOTECHNOLOGY
- 3D bioprinting of tissues and organs
- (2014) Sean V Murphy et al. NATURE BIOTECHNOLOGY
- Influence of the microenvironment on cell fate determination and migration
- (2014) Alexander B. Bloom et al. PHYSIOLOGICAL GENOMICS
- Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines
- (2014) Thibault Bricks et al. TOXICOLOGY IN VITRO
- Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis
- (2014) Olivier Frey et al. Nature Communications
- Materials for Microfluidic Chip Fabrication
- (2013) Kangning Ren et al. ACCOUNTS OF CHEMICAL RESEARCH
- An estimation of the number of cells in the human body
- (2013) Eva Bianconi et al. ANNALS OF HUMAN BIOLOGY
- Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based bio-microelectromechanical systems device
- (2013) K. L. Pirozzi et al. APPLIED PHYSICS LETTERS
- Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1
- (2013) Xiufang Guo et al. BIOMATERIALS
- Dynamic three-dimensional micropatterned cell co-cultures within photocurable and chemically degradable hydrogels
- (2013) Shinji Sugiura et al. Journal of Tissue Engineering and Regenerative Medicine
- Microfluidic heart on a chip for higher throughput pharmacological studies
- (2013) Ashutosh Agarwal et al. LAB ON A CHIP
- Microfabricated mammalian organ systems and their integration into models of whole animals and humans
- (2013) Jong H. Sung et al. LAB ON A CHIP
- A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
- (2013) Ilka Wagner et al. LAB ON A CHIP
- Vascularized and functional human liver from an iPSC-derived organ bud transplant
- (2013) Takanori Takebe et al. NATURE
- Cerebral organoids model human brain development and microcephaly
- (2013) Madeline A. Lancaster et al. NATURE
- Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
- (2013) Sarah X L Huang et al. NATURE BIOTECHNOLOGY
- The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline
- (2013) Margaret L Sutherland et al. Stem Cell Research & Therapy
- Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
- (2013) Ryan C. Elkins et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
- Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models
- (2012) Paul M. van Midwoud et al. ANALYTICAL CHEMISTRY
- Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity
- (2012) Yuki IMURA et al. ANALYTICAL SCIENCES
- Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons
- (2012) Xiufang Guo et al. BIOMATERIALS
- Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip
- (2012) Leila Choucha-Snouber et al. BIOTECHNOLOGY AND BIOENGINEERING
- Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: Results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen
- (2012) Albert P. Li et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)
- (2012) Ross Booth et al. LAB ON A CHIP
- Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
- (2012) Ethan S Lippmann et al. NATURE BIOTECHNOLOGY
- Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia
- (2012) Elisabetta Iori et al. PLoS One
- Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
- (2012) X. Lian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
- (2012) I. K. Zervantonakis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies
- (2011) M.B. Esch et al. Annual Review of Biomedical Engineering
- Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system
- (2011) Xiufang Guo et al. BIOMATERIALS
- Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform
- (2011) Anupama Natarajan et al. BIOMATERIALS
- Whispering gallery mode biosensor quantification of fibronectin adsorption kinetics onto alkylsilane monolayers and interpretation of resultant cellular response
- (2011) Kerry A. Wilson et al. BIOMATERIALS
- Skeletal myotube integration with planar microelectrode arrays in vitro for spatially selective recording and stimulation: A comparison of neuronal and myotube extracellular action potentials
- (2011) Christopher G. Langhammer et al. BIOTECHNOLOGY PROGRESS
- BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems
- (2011) John F. Graf et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
- Design of a shear-thinning recoverable peptide hydrogel from native sequences and application for influenza H1N1 vaccine adjuvant
- (2011) Hongzhou Huang et al. Soft Matter
- Biocompatibility and Reduced Drug Absorption of Sol−Gel-Treated Poly(dimethyl siloxane) for Microfluidic Cell Culture Applications
- (2010) Rafael Gomez-Sjoberg et al. ANALYTICAL CHEMISTRY
- Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity
- (2010) Yuki Imura et al. ANALYTICAL CHEMISTRY
- Tissue engineering the mechanosensory circuit of the stretch reflex arc: Sensory neuron innervation of intrafusal muscle fibers
- (2010) John W. Rumsey et al. BIOMATERIALS
- A defined long-term in vitro tissue engineered model of neuromuscular junctions
- (2010) Mainak Das et al. BIOMATERIALS
- Flow-regulated glucose and lipid metabolism in adipose tissue, endothelial cell and hepatocyte cultures in a modular bioreactor
- (2010) Bruna Vinci et al. Biotechnology Journal
- Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
- (2010) D Eastwood et al. BRITISH JOURNAL OF PHARMACOLOGY
- Promises, challenges and future directions of μCCAs
- (2010) Mandy B. Esch et al. JOURNAL OF BIOTECHNOLOGY
- A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip
- (2010) Jong Hwan Sung et al. LAB ON A CHIP
- A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
- (2010) Paul M. van Midwoud et al. LAB ON A CHIP
- Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
- (2010) Jason R. Spence et al. NATURE
- A New Target for Amyloid Beta Toxicity Validated by Standard and High-Throughput Electrophysiology
- (2010) Kucku Varghese et al. PLoS One
- Measurement of Contractile Stress Generated by Cultured Rat Muscle on Silicon Cantilevers for Toxin Detection and Muscle Performance Enhancement
- (2010) Kerry Wilson et al. PLoS One
- Parylene-coating in PDMS microfluidic channels prevents the absorption of fluorescent dyes
- (2010) Hirotaka Sasaki et al. SENSORS AND ACTUATORS B-CHEMICAL
- Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap
- (2009) Jong Hwan Sung et al. BIOMEDICAL MICRODEVICES
- Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity
- (2009) Gretchen J. Mahler et al. BIOTECHNOLOGY AND BIOENGINEERING
- Hydrogels as extracellular matrix mimics for 3D cell culture
- (2009) Mark W. Tibbitt et al. BIOTECHNOLOGY AND BIOENGINEERING
- Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies
- (2009) Paul M. van Midwoud et al. BIOTECHNOLOGY AND BIOENGINEERING
- Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells
- (2009) Donghui Zhang et al. CELL RESEARCH
- Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
- (2009) Jianhua Zhang et al. CIRCULATION RESEARCH
- Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
- (2009) Karim Si-Tayeb et al. HEPATOLOGY
- Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons
- (2009) Xiufang Guo et al. Journal of Tissue Engineering and Regenerative Medicine
- Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments
- (2009) Chi Zhang et al. LAB ON A CHIP
- A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
- (2009) Jong Hwan Sung et al. LAB ON A CHIP
- Generation of pluripotent stem cells from patients with type 1 diabetes
- (2009) R. Maehr et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons
- (2009) Saravanan Karumbayaram et al. STEM CELLS
- Recent Advances in Cell Micropatterning Techniques for Bioanalytical and Biomedical Sciences
- (2008) Jun NAKANISHI et al. ANALYTICAL SCIENCES
- A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers
- (2008) Daniel A. Tatosian et al. BIOTECHNOLOGY AND BIOENGINEERING
- Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability☆
- (2008) Gretchen J. Mahler et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Drug-screening platform based on the contractility of tissue-engineered muscle
- (2008) Herman Vandenburgh et al. MUSCLE & NERVE
- Generation of human induced pluripotent stem cells from dermal fibroblasts
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- Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
- (2008) J. T. Dimos et al. SCIENCE
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- Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies
- (2004) Kwanchanok Viravaidya et al. BIOTECHNOLOGY PROGRESS
- The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors
- (2004) Aaron Sin et al. BIOTECHNOLOGY PROGRESS
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