Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

Multiorgan-on-a-Chip: A Systemic Approach To Model and Decipher Inter-Organ Communication

(2021) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

Modeling the Human Body on Microfluidic Chips

(2021) Sasan Jalili-Firoozinezhad et al.   TRENDS IN BIOTECHNOLOGY

An American Physiological Society cross-journal Call for Papers on "Inter-Organ Communication in Homeostasis and Disease"

(2021) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Modeling Immunity In Vitro: Slices, Chips, and Engineered Tissues

(2021) Jennifer H. Hammel et al.   Annual Review of Biomedical Engineering

Organs-on-a-chip models for biological research

(2021) Gordana Vunjak-Novakovic et al.   CELL

Harnessing organs-on-a-chip to model tissue regeneration

(2021) Daniel Naveed Tavakol et al.   Cell Stem Cell

Coculture of primary human colon monolayer with human gut bacteria

(2021) Jianbo Zhang et al.   Nature Protocols

A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems

(2021) Kenta Shinha et al.   Micromachines

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

(2021) Mridu Malik et al.   Frontiers in Cell and Developmental Biology

Transforming a well into a chip: A modular 3D-printed microfluidic chip

(2021) Rossana Rauti et al.   APL Bioengineering

Respecting Autonomy And Enabling Diversity: The Effect Of Eligibility And Enrollment On Research Data Demographics

(2021) Kayte Spector-Bagdady et al.   HEALTH AFFAIRS

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Blood and Lymphatic Vasculatures On-Chip Platforms and Their Applications for Organ-Specific In Vitro Modeling

(2020) Aria R. Henderson et al.   Micromachines

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model

(2020) Y Baert et al.   HUMAN REPRODUCTION

Multitissue Multiomics Systems Biology to Dissect Complex Diseases

(2020) Xia Yang   TRENDS IN MOLECULAR MEDICINE

Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip

(2020) Trevor Sasserath et al.   Advanced Science

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

(2020) Martin Trapecar et al.   Cell Systems

Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

(2020) Bing Zhang et al.   GUT

Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis

(2020) Ayan Mondal et al.   Journal of Neuroinflammation

Organ System Crosstalk in Cardiometabolic Disease in the Age of Multimorbidity

(2020) Yumiko Oishi et al.   Frontiers in Cardiovascular Medicine

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications

(2020) Margaretha Morsink et al.   Micromachines

An evolutionary perspective on immunometabolism

(2019) Andrew Wang et al.   SCIENCE

Computational translation of genomic responses from experimental model systems to humans

(2019) Douglas K. Brubaker et al.   PLoS Computational Biology

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

(2019) Frederik J. Verweij et al.   DEVELOPMENTAL CELL

Tissue-Resident T Cells and Other Resident Leukocytes

(2019) David Masopust et al.   Annual Review of Immunology

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Analysis of an Integrated Human Multiorgan Microphysiological System for Combined Tolcapone Metabolism and Brain Metabolomics

(2019) Xin Wang et al.   ANALYTICAL CHEMISTRY

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

Inter‐organ communication: a gatekeeper for metabolic health

(2019) Judit Castillo‐Armengol et al.   EMBO REPORTS

Gut-liver on a chip towards an in vitro model of hepatic steatosis

(2018) Seung Yeon Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Interorgan Metabolic Crosstalk in Human Insulin Resistance

(2018) Sofiya Gancheva et al.   PHYSIOLOGICAL REVIEWS

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Circadian hormone control in a human-on-a-chip: In vitro biology’s ignored component?

(2017) Kevin J. Cyr et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

An engineering design approach to systems biology

(2017) Kevin A. Janes et al.   Integrative Biology

Complex systems biology

(2017) Avi Ma'ayan   Journal of the Royal Society Interface

Bone marrow-on-a-chip: Long-term culture of human haematopoietic stem cells in a three-dimensional microfluidic environment

(2017) Stefan Sieber et al.   Journal of Tissue Engineering and Regenerative Medicine

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

(2017) Shomyseh Sanjabi et al.   Cold Spring Harbor Perspectives in Biology

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

(2017) Ying I. Wang et al.   Advanced Healthcare Materials

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

Design and demonstration of a pumpless 14 compartment microphysiological system

(2016) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device

(2016) Patrícia Moura Rosa et al.   LAB ON A CHIP

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

How gut microbes talk to organs: The role of endocrine and nervous routes

(2016) Patrice D. Cani et al.   Molecular Metabolism

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

Infection and immunity on a chip: a compartmentalised microfluidic platform to monitor immune cell behaviour in real time

(2015) N. Gopalakrishnan et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Microcirculation-on-a-Chip: A Microfluidic Platform for Assaying Blood- and Lymphatic-Vessel Permeability

(2015) Miwa Sato et al.   PLoS One

Adipose tissue and its role in organ crosstalk

(2014) T. Romacho et al.   Acta Physiologica

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

A Co-Culture Model of the Developing Small Intestine Offers New Insight in the Early Immunomodulation of Enterocytes and Macrophages by Lactobacillus spp. through STAT1 and NF-kB p65 Translocation

(2014) Martin Trapecar et al.   PLoS One

A standalone perfusion platform for drug testing and target validation in micro-vessel networks

(2013) Boyang Zhang et al.   Biomicrofluidics

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Models of signalling networks - what cell biologists can gain from them and give to them

(2013) K. A. Janes et al.   JOURNAL OF CELL SCIENCE

Microdevice integrating innate and adaptive immune responses associated with antigen presentation by dendritic cells

(2013) Bhaskar Mitra et al.   RSC Advances

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

(2013) Gordana Vunjak-Novakovic et al.   Stem Cell Research & Therapy

Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion

(2012) Sung Kyu Kim et al.   ANALYST

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The use of a porcine intestinal cell model system for evaluating the food safety risk of Bacillus cereus probiotics and the implications for assessing enterotoxigenicity

(2011) MARTIN TRAPECAR et al.   APMIS

A microfluidic membrane device to mimic critical components of the vascular microenvironment

(2011) Suthan Srigunapalan et al.   Biomicrofluidics

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

(2011) U. Haessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE