Gut-liver axis: Pathophysiological concepts and clinical implications

Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens

(2022) Laura Valestrand et al.   AMERICAN JOURNAL OF PATHOLOGY

Revisiting the gut-liver axis: gut lymphatic system in liver cirrhosis and portal hypertension

(2022) Pinky Juneja et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

(2022) Martin Guilliams et al.   CELL

Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity

(2022) Irina Leonardi et al.   CELL

Mucosal immunity in primary sclerosing cholangitis: from the bowel to bile ducts and back again

(2022) Evaggelia Liaskou et al.   CURRENT OPINION IN GASTROENTEROLOGY

Colonic interleukin‐22 protects intestinal mucosal barrier and microbiota abundance in severe acute pancreatitis

(2022) Meng Jin et al.   FASEB JOURNAL

Pattern Recognition Receptor Signaling and Cytokine Networks in Microbial Defenses and Regulation of Intestinal Barriers: Implications for Inflammatory Bowel Disease

(2022) Clara Abraham et al.   GASTROENTEROLOGY

Gut microbiome and health: mechanistic insights

(2022) Willem M de Vos et al.   GUT

Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

(2022) Claudia D. Fuchs et al.   Nature Reviews Gastroenterology & Hepatology

Gut barrier disruption and chronic disease

(2022) Jan Martel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence

(2022) Hung-Yu Chiang et al.   Nature Communications

Circulating microbiome in patients with portal hypertension

(2022) Rolandas Gedgaudas et al.   Gut Microbes

Machine Learning Applied to Omics Datasets Predicts Mortality in Patients with Alcoholic Hepatitis

(2022) Bei Gao et al.   Metabolites

Liver microbes controlling immunity: Facts and pitfalls

(2022) Herbert Tilg et al.   Cell Metabolism

Discovery of farnesoid X receptor and its role in bile acid metabolism

(2022) John Y.L. Chiang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

(2022) Donggi Paik et al.   NATURE

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

(2022) Victoria Acosta-Rodríguez et al.   SCIENCE

Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile

(2022) Nicole G. Metzendorf et al.   Frontiers in Microbiology

The microbiome and gut homeostasis

(2022) Jee-Yon Lee et al.   SCIENCE

Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome

(2022) Ana Carolina Dantas Machado et al.   Cell Reports

A microbial metabolite remodels the gut-liver axis following bariatric surgery

(2021) Snehal N. Chaudhari et al.   Cell Host & Microbe

The use of Rifaximin in Patients with Cirrhosis

(2021) Paolo Caraceni et al.   HEPATOLOGY

Multi-kingdom ecological drivers of microbiota assembly in preterm infants

(2021) Chitong Rao et al.   NATURE

Urban living in healthy Tanzanians is associated with an inflammatory status driven by dietary and metabolic changes

(2021) Godfrey S. Temba et al.   NATURE IMMUNOLOGY

Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation

(2021) Nicholas Jones et al.   Nature Communications

FXR agonists for NASH: How are they different and what difference do they make?

(2021) Claus Kremoser   JOURNAL OF HEPATOLOGY

Reconstruction of ancient microbial genomes from the human gut

(2021) Marsha C. Wibowo et al.   NATURE

The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics

(2021) Seppo Salminen et al.   Nature Reviews Gastroenterology & Hepatology

Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice

(2021) Noreen McBrearty et al.   NEOPLASIA

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

(2021) Hyo Shin Yoon et al.   Nature Microbiology

A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

(2021) Patrice D. Cani et al.   Cell Metabolism

Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

(2021) Brigida Barberio et al.   GASTROENTEROLOGY

The Emerging Role of Glucagon-like Peptide-1 Receptor Agonists for the Management of NAFLD

(2021) Chandani Patel Chavez et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The microbiota in cirrhosis and its role in hepatic decompensation

(2021) Jonel Trebicka et al.   JOURNAL OF HEPATOLOGY

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

(2021) Omar Delannoy-Bruno et al.   NATURE

Caloric restriction disrupts the microbiota and colonization resistance

(2021) Reiner Jumpertz von Schwartzenberg et al.   NATURE

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

(2021) Yuko Sato et al.   NATURE

Enterically derived high-density lipoprotein restrains liver injury through the portal vein

(2021) Yong-Hyun Han et al.   SCIENCE

Role of FXR in Bile Acid and Metabolic Homeostasis in NASH: Pathogenetic Concepts and Therapeutic Opportunities

(2021) Richard Radun et al.   SEMINARS IN LIVER DISEASE

Aryl Hydrocarbon Receptor Deficiency in Intestinal Epithelial Cells Aggravates Alcohol-Related Liver Disease

(2021) Minyi Qian et al.   Cellular and Molecular Gastroenterology and Hepatology

“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis

(2021) Mark A. Febbraio et al.   Cell Metabolism

Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance

(2021) Jelena Remetic et al.   HEPATOLOGY

The fecal mycobiome in non-alcoholic fatty liver disease

(2021) Münevver Demir et al.   JOURNAL OF HEPATOLOGY

The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

(2021) Tom H Karlsen et al.   LANCET

Advancing the global public health agenda for NAFLD: a consensus statement

(2021) Jeffrey V. Lazarus et al.   Nature Reviews Gastroenterology & Hepatology

CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease

(2021) Yi Duan et al.   Nature Communications

The Pathophysiology of Farnesoid X Receptor (FXR) in the GI Tract: Inflammation, Barrier Function and Innate Immunity

(2021) Kemp M. Anderson et al.   Cells

The gut microbiota instructs the hepatic endothelial cell transcriptome

(2021) Henning Formes et al.   iScience

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

(2021) Benoit Chassaing et al.   GASTROENTEROLOGY

Akkermansia muciniphila Prevents Fatty Liver, Decreases Serum Triglycerides, and Maintains Gut Homeostasis

(2020) Sejeong Kim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals

(2020) Xiuli Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice

(2020) Mingming Zhao et al.   GASTROENTEROLOGY

Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease

(2020) Anand R. Saran et al.   GASTROENTEROLOGY

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure

(2020) Cornelius Engelmann et al.   JOURNAL OF HEPATOLOGY

Global chemical effects of the microbiome include new bile-acid conjugations

(2020) Robert A. Quinn et al.   NATURE

Immune-Microbiota Interplay and Colonization Resistance in Infection

(2020) Avner Leshem et al.   MOLECULAR CELL

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

Perivascular localization of macrophages in the intestinal mucosa is regulated by Nr4a1 and the microbiome

(2020) Masaki Honda et al.   Nature Communications

Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels

(2020) Elizabeth L. Johnson et al.   Nature Communications

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis

(2020) Tae Gyu Oh et al.   Cell Metabolism

Trimethylamine N-Oxide levels are associated with NASH in obese subjects with type 2 diabetes

(2020) Paola León-Mimila et al.   DIABETES & METABOLISM

Bariatric Surgery Provides Long-term Resolution of Nonalcoholic Steatohepatitis and Regression of Fibrosis

(2020) Guillaume Lassailly et al.   GASTROENTEROLOGY

High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function

(2020) Inna Grosheva et al.   GASTROENTEROLOGY

Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis

(2020) Stephen A. Harrison et al.   GASTROENTEROLOGY

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

(2020) Xiang Zhang et al.   GUT

Microbiomics, metabolomics, predicted metagenomics and hepatic steatosis in a population‐based study of 1355 adults

(2020) Louise JM Alferink et al.   HEPATOLOGY

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders

(2020) Saul J. Karpen et al.   Hepatology International

SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD

(2020) Mingjuan Deng et al.   JOURNAL OF ENDOCRINOLOGY

A Systems Biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study

(2020) CC Van Olden et al.   JOURNAL OF INTERNAL MEDICINE

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

(2020) Masanori Funabashi et al.   NATURE

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

(2020) Toshiaki Teratani et al.   NATURE

Molecular Physiology of Bile Acid Signaling in Health, Disease and Aging

(2020) Alessia Perino et al.   PHYSIOLOGICAL REVIEWS

Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis

(2020) Timur Tuganbaev et al.   CELL

Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection

(2020) Braedon McDonald et al.   Cell Host & Microbe

ALTERATIONS IN GUT MICROBIOME IN CIRRHOSIS AS ASSESSED BY QUANTITATIVE METAGENOMICS. RELATIONSHIP WITH ACUTE-ON-CHRONIC LIVER FAILURE AND PROGNOSIS

(2020) Cristina Solé et al.   GASTROENTEROLOGY

Targeting the gut-liver-immune axis to treat cirrhosis

(2020) Thomas Henry Tranah et al.   GUT

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

(2020) Laura Wrzosek et al.   GUT

Oral vancomycin, ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis

(2020) Mark R. Deneau   HEPATOLOGY

Variation in Bile Microbiome by the Etiology of Cholestatic Liver Disease

(2020) Olaf Tyc et al.   LIVER TRANSPLANTATION

Bile acid toxicity in Paneth cells contributes to gut dysbiosis induced by high-fat feeding

(2020) Hui Zhou et al.   JCI Insight

Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis

(2020) David C. Montrose et al.   Cellular and Molecular Gastroenterology and Hepatology

Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

(2020) Xiaojiao Zheng et al.   Cell Metabolism

Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis

(2020) Martin Kummen et al.   GASTROENTEROLOGY

Chronic Liver Diseases and the Microbiome—Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease

(2020) Chathur Acharya et al.   GASTROENTEROLOGY

Gut microbiota-derived metabolites as central regulators in metabolic disorders

(2020) Allison Agus et al.   GUT

Bile Salts Differentially Enhance Resistance of Enterohemorrhagic Escherichia coli O157:H7 to Host Defense Peptides

(2020) Crystal Gadishaw-Lue et al.   INFECTION AND IMMUNITY

High-Fructose Diet Increases Inflammatory Cytokines and Alters Gut Microbiota Composition in Rats

(2020) Yong Wang et al.   MEDIATORS OF INFLAMMATION

Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure

(2020) Jonel Trebicka et al.   Nature Reviews Gastroenterology & Hepatology

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

(2020) Philip N. Newsome et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

(2019) Nobuhiro Nakamoto et al.   Nature Microbiology

NGM 282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients with Nonalcoholic Steatohepatitis

(2019) Stephen A. Harrison et al.   HEPATOLOGY

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

(2019) Lijun Liao et al.   GUT

Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis

(2019) Jessica R. Allegretti et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Systematic review with meta-analysis: risk factors for recurrent primary sclerosing cholangitis after liver transplantation

(2019) Iris C. Steenstraten et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Alterations of the bile microbiome in primary sclerosing cholangitis

(2019) Timur Liwinski et al.   GUT

Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis

(2019) Sonja Lang et al.   HEPATOLOGY

FxR-modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis

(2019) M. Sorribas et al.   JOURNAL OF HEPATOLOGY

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

(2019) Ayesha Shah et al.   SEMINARS IN LIVER DISEASE

Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind, randomised, placebo-controlled, phase 2 dose-finding trial

(2019) Stefan Traussnigg et al.   Lancet Gastroenterology & Hepatology

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

(2019) Stefan Jordan et al.   CELL

Probiotic LGG prevents liver fibrosis through inhibiting hepatic bile acid synthesis and enhancing bile acid excretion in mice

(2019) Yunhuan Liu et al.   HEPATOLOGY

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease

(2019) Huikuan Chu et al.   JOURNAL OF HEPATOLOGY

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease

(2019) Guido Carpino et al.   HEPATOLOGY

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression

(2019) Fabián Segovia-Miranda et al.   NATURE MEDICINE

Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism

(2019) Katya Frazier et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Review article: the evidence that vancomycin is a therapeutic option for primary sclerosing cholangitis

(2018) J. L. Damman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

(2018) Kristina Martinez-Guryn et al.   Cell Host & Microbe

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

(2018) Kassem Makki et al.   Cell Host & Microbe

Circulating microbiome in blood of different circulatory compartments

(2018) Robert Schierwagen et al.   GUT

Inflammatory Bowel Disease and Primary Sclerosing Cholangitis: A Review of the Phenotype and Associated Specific Features

(2018) Carolina Palmela et al.   Gut and Liver

Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort

(2018) Jasmohan S. Bajaj et al.   HEPATOLOGY

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Glucagon-like peptide 1 in health and disease

(2018) Andreas Andersen et al.   Nature Reviews Endocrinology

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis

(2018) Sebastiaan De Schepper et al.   CELL

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis

(2018) Amandeep K Dhillon et al.   LIVER INTERNATIONAL

β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor

(2018) Thomas Klag et al.   Frontiers in Immunology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

(2018) Elliot S. Friedman et al.   GASTROENTEROLOGY

Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis

(2018) Leticia Muñoz et al.   HEPATOLOGY

Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial

(2018) Gideon M. Hirschfield et al.   JOURNAL OF HEPATOLOGY

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis

(2017) Gabriele Giacomo Schiattarella et al.   EUROPEAN HEART JOURNAL

Bile acids deoxycholic acid and ursodeoxycholic acid differentially regulate human β-defensin-1 and -2 secretion by colonic epithelial cells

(2017) Natalia K. Lajczak et al.   FASEB JOURNAL

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

(2017) Tobias J. Weismüller et al.   GASTROENTEROLOGY

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

(2017) Na Jiao et al.   GUT

Recovery of ethanol-inducedAkkermansia muciniphiladepletion ameliorates alcoholic liver disease

(2017) Christoph Grander et al.   GUT

New therapeutic concepts in bile acid transport and signaling for management of cholestasis

(2017) Michael Trauner et al.   HEPATOLOGY

Primary sclerosing cholangitis – a comprehensive review

(2017) Tom H. Karlsen et al.   JOURNAL OF HEPATOLOGY

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

(2017) Philipp Schwabl et al.   JOURNAL OF HEPATOLOGY

Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis

(2017) Cen Xie et al.   NATURE MEDICINE

Genetics of primary sclerosing cholangitis and pathophysiological implications

(2017) Xiaojun Jiang et al.   Nature Reviews Gastroenterology & Hepatology

Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis

(2017) Hana Sarashina-Kida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts

(2017) Johannes Hov et al.   SEMINARS IN LIVER DISEASE

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

The Cardiovascular Biology of Glucagon-like Peptide-1

(2016) Daniel J. Drucker   Cell Metabolism

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

(2016) Cen Xie et al.   DIABETES

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

(2016) Frank J. Gonzalez et al.   GASTROENTEROLOGY

Primary sclerosing cholangitis: 50 years of a gut–liver relationship and still no love?

(2016) Tom H Karlsen   GUT

Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis

(2016) Benjamin Lelouvier et al.   HEPATOLOGY

Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats

(2016) María Úbeda et al.   JOURNAL OF HEPATOLOGY

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults

(2016) Yu-ming Chen et al.   Scientific Reports

Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?

(2015) P. Pavlidis et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats

(2015) Len Verbeke et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

(2015) Jonathan Y. Xia et al.   Cell Metabolism

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

(2015) James H. Tabibian et al.   HEPATOLOGY

Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice

(2015) Peng Chen et al.   HEPATOLOGY

Does low-dose rifaximin ameliorate endotoxemia in patients with liver cirrhosis: a prospective study

(2015) Xin Zeng et al.   Journal of Digestive Diseases

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

(2015) Michaela Mueller et al.   JOURNAL OF HEPATOLOGY

New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

(2015) Ulrich Beuers et al.   JOURNAL OF HEPATOLOGY

Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time

(2015) Cathrin Sellmann et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

(2014) M. Zhou et al.   CANCER RESEARCH

Interactions Between the Intestinal Microbiome and Liver Diseases

(2014) Bernd Schnabl et al.   GASTROENTEROLOGY

Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

(2014) Xiang Gao et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Mechanism of IL-1 -Induced Increase in Intestinal Epithelial Tight Junction Permeability

(2014) R. Al-Sadi et al.   JOURNAL OF IMMUNOLOGY

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

(2014) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Diets rich in n-6 PUFA induce intestinal microbial dysbiosis in aged mice

(2013) Sanjoy Ghosh et al.   BRITISH JOURNAL OF NUTRITION

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

(2013) Iker Uriarte et al.   GUT

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

FGF19 action in the brain induces insulin-independent glucose lowering

(2013) Gregory J. Morton et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

(2013) Genta Kakiyama et al.   JOURNAL OF HEPATOLOGY

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency

(2013) L. A. Tellez et al.   SCIENCE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

(2012) Swaroop Pendyala et al.   GASTROENTEROLOGY

Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19

(2012) Masaaki Miyata et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Characterization of fecal microbial communities in patients with liver cirrhosis

(2011) Yanfei Chen et al.   HEPATOLOGY

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(2011) Herbert Tilg et al.   JOURNAL OF HEPATOLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

(2011) B. D. Muegge et al.   SCIENCE

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Endotoxin and Plasminogen Activator Inhibitor-1 Serum Levels Associated With Nonalcoholic Steatohepatitis in Children

(2010) Anna Alisi et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

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High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

(2009) Marie A. Hildebrandt et al.   GASTROENTEROLOGY

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

(2009) Luca Miele et al.   HEPATOLOGY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium

(2008) Emilie D'Aldebert et al.   GASTROENTEROLOGY

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

(2008) Frank G. Schaap et al.   HEPATOLOGY

Chylomicrons promote intestinal absorption of lipopolysaccharides

(2008) Sarbani Ghoshal et al.   JOURNAL OF LIPID RESEARCH