A microbial metabolite remodels the gut-liver axis following bariatric surgery

Development of a covalent inhibitor of gut bacterial bile salt hydrolases

(2020) Arijit A. Adhikari et al.   Nature Chemical Biology

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

(2020) Masanori Funabashi et al.   NATURE

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

(2019) Pierre Larraufie et al.   Cell Reports

Comparison of early type 2 diabetes improvement after gastric bypass and sleeve gastrectomy: medication cessation at discharge predicts 1-year outcomes

(2019) Keyvan Heshmati et al.   Surgery for Obesity and Related Diseases

Role of Bile Acids in Bariatric Surgery

(2019) Wenting Wang et al.   Frontiers in Physiology

Measurement of gut microbial metabolites in cardiometabolic health and translational research

(2019) Wei‐Kai Wu et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Antibiotic-induced Disruption of Intestinal Microbiota Contributes to Failure of Vertical Sleeve Gastrectomy

(2018) Cyrus Jahansouz et al.   ANNALS OF SURGERY

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

(2018) Kristina Martinez-Guryn et al.   Cell Host & Microbe

A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies

(2018) Hsih-Yin Tan et al.   PLoS One

A selective gut bacterial bile salt hydrolase alters host metabolism

(2018) Lina Yao et al.   eLife

Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure

(2018) Guoxiang Xie et al.   EBioMedicine

Vitamin D alteration associated with obesity and bariatric surgery

(2017) Eric Lespessailles et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Unveiling the “Magic” of Diabetes Remission After Weight-Loss Surgery

(2017) Jennifer Abbasi   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8)

(2017) Lu Feng et al.   JOURNAL OF LIPID RESEARCH

Will the real bile acid sulfotransferase please stand up? Identification ofSult2a8as a major hepatic bile acid sulfonating enzyme in mice

(2017) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis

(2017) Dimitrios E. Magouliotis et al.   OBESITY SURGERY

Sleeve gastrectomy drives persistent shifts in the gut microbiome

(2017) Cyrus Jahansouz et al.   Surgery for Obesity and Related Diseases

A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients

(2017) Andrew Brantley Hall et al.   Genome Medicine

Distinct patterns in the gut microbiota after surgical or medical therapy in obese patients

(2017) Daniel A. Medina et al.   PeerJ

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight

(2016) Stephanie R. Sisley et al.   DIABETES

Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

(2016) Lili Ding et al.   HEPATOLOGY

Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota

(2016) Annika Wahlström et al.   JOURNAL OF LIPID RESEARCH

DADA2: High-resolution sample inference from Illumina amplicon data

(2016) Benjamin J Callahan et al.   NATURE METHODS

Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome

(2016) Lukasz Kaska et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolomic fingerprint of severe obesity is dynamically affected by bariatric surgery in a procedure-dependent manner

(2015) Ewa Gralka et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

(2015) Valentina Tremaroli et al.   Cell Metabolism

TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice

(2015) Anne K McGavigan et al.   GUT

Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4

(2015) Carolien Out et al.   JOURNAL OF HEPATOLOGY

Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

(2015) Stefano Fiorucci et al.   TRENDS IN MOLECULAR MEDICINE

Effects of Surgical and Dietary Weight Loss Therapy for Obesity on Gut Microbiota Composition and Nutrient Absorption

(2015) Antje Damms-Machado et al.   Biomed Research International

Enhanced oral bioavailability of vancomycin in rats treated with long-term parenteral nutrition

(2015) Keizo Fukushima et al.   SpringerPlus

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

c-Fos mediates repression of the apical sodium-dependent bile acid transporter by fibroblast growth factor-19 in mice

(2013) Ayantika Ghosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of the cytosolic sulfotransferases by nuclear receptors

(2013) Melissa Runge-Morris et al.   DRUG METABOLISM REVIEWS

Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

(2013) Rohit Kohli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

A protocol for differentiation of human intestinal Caco-2 cells in asymmetric serum-containing medium

(2012) Simonetta Ferruzza et al.   TOXICOLOGY IN VITRO

Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

(2010) Quan Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Analyses of Copy Number Variation of GK Rat Reveal New Putative Type 2 Diabetes Susceptibility Loci

(2010) Zhi-Qiang Ye et al.   PLoS One

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

(2009) P. D. Schloss et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Xenobiotic-Sensing Nuclear Receptors CAR and PXR as Drug Targets in Cholestatic Liver Disease

(2009) Satoru Kakizaki et al.   CURRENT DRUG TARGETS

Bile acid transporters

(2009) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility

(2009) Marshall B. Elam et al.   Obesity

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

(2009) Yazen Alnouti   TOXICOLOGICAL SCIENCES

Mechanism of Vitamin D Receptor Inhibition of Cholesterol 7 -Hydroxylase Gene Transcription in Human Hepatocytes

(2008) S. Han et al.   DRUG METABOLISM AND DISPOSITION

Intestinal bile acid physiology and pathophysiology

(2008) Olga Martínez-Augustin et al.   WORLD JOURNAL OF GASTROENTEROLOGY