Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens

A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells

(2021) Christine L. Zimmer et al.   Science Translational Medicine

Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities

(2020) Mette Vesterhus et al.   JOURNAL OF GASTROENTEROLOGY

Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells

(2020) Laura Valestrand et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

(2019) Nobuhiro Nakamoto et al.   Nature Microbiology

Activated and Exhausted MAIT Cells Foster Disease Progression and Indicate Poor Outcome in Hepatocellular Carcinoma

(2019) Meng Duan et al.   CLINICAL CANCER RESEARCH

Alterations of the bile microbiome in primary sclerosing cholangitis

(2019) Timur Liwinski et al.   GUT

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

(2019) Evan Bolyen et al.   NATURE BIOTECHNOLOGY

Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

(2019) Ayesha Shah et al.   SEMINARS IN LIVER DISEASE

The human gallbladder microbiome is related to the physiological state and the biliary metabolic profile

(2019) Natalia Molinero et al.   Microbiome

The biology and functional importance of MAIT cells

(2019) Dale I. Godfrey et al.   NATURE IMMUNOLOGY

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

(2019) Michael G. Constantinides et al.   SCIENCE

A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus

(2019) Goh Murayama et al.   Frontiers in Immunology

MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation

(2018) Katrin Böttcher et al.   HEPATOLOGY

Mucosal-associated invariant T cells in autoimmune and immune-mediated diseases

(2018) Ophélie Rouxel et al.   IMMUNOLOGY AND CELL BIOLOGY

The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7

(2018) Xiang Jiang et al.   JOURNAL OF AUTOIMMUNITY

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

(2018) Pushpa Hegde et al.   Nature Communications

Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells

(2018) Erik von Seth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation

(2018) Cihan Tastan et al.   Mucosal Immunology

MAIT cells protect against pulmonary Legionella longbeachae infection

(2018) Huimeng Wang et al.   Nature Communications

Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization

(2018) Yanmei Li et al.   Frontiers in Immunology

Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation

(2017) Fabian J. Bolte et al.   GASTROENTEROLOGY

Primary sclerosing cholangitis – a comprehensive review

(2017) Tom H. Karlsen et al.   JOURNAL OF HEPATOLOGY

TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells

(2016) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD

(2016) João Sabino et al.   GUT

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

(2016) Martin Kummen et al.   GUT

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

(2016) Hannah C. Jeffery et al.   JOURNAL OF HEPATOLOGY

Primary Sclerosing Cholangitis

(2016) Konstantinos N. Lazaridis et al.   NEW ENGLAND JOURNAL OF MEDICINE

MAIT cells are activated during human viral infections

(2016) Bonnie van Wilgenburg et al.   Nature Communications

IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions

(2015) Arne Sattler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The biliary epithelium presents antigens to and activates natural killer T cells

(2015) Elisabeth Schrumpf et al.   HEPATOLOGY

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites

(2015) Isaac G. Sakala et al.   JOURNAL OF IMMUNOLOGY

In Vitro and In Vivo Analysis of the Gram-Negative Bacteria–Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells

(2015) Claire Soudais et al.   JOURNAL OF IMMUNOLOGY

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

(2014) A Kurioka et al.   Mucosal Immunology

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

An improved dual-indexing approach for multiplexed 16S rRNA gene sequencing on the Illumina MiSeq platform

(2014) Douglas W Fadrosh et al.   Microbiome

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

(2013) Anne Vrieze et al.   JOURNAL OF HEPATOLOGY

IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells

(2013) X.-Z. Tang et al.   JOURNAL OF IMMUNOLOGY

Primary sclerosing cholangitis

(2013) Gideon M Hirschfield et al.   LANCET

Primary sclerosing cholangitis and bile acids

(2012) Olivier Chazouillères   Clinics and Research in Hepatology and Gastroenterology

IMG: the integrated microbial genomes database and comparative analysis system

(2011) V. M. Markowitz et al.   NUCLEIC ACIDS RESEARCH

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Hyponatremia and Mortality among Patients on the Liver-Transplant Waiting List

(2008) W. Ray Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE