New therapeutic concepts in bile acid transport and signaling for management of cholestasis

Metabolic preconditioning protects BSEP / ABCB11 −/− mice against cholestatic liver injury

(2017) Claudia D. Fuchs et al.   JOURNAL OF HEPATOLOGY

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Farnesoid X Receptor Agonists and Other Bile Acid Signaling Strategies for Treatment of Liver Disease

(2016) Emina Halilbasic et al.   DIGESTIVE DISEASES

Hepatitis B virus receptors and molecular drug targets

(2016) Eloi R. Verrier et al.   Hepatology International

Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis

(2016) Anna Baghdasaryan et al.   JOURNAL OF HEPATOLOGY

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

(2016) Natalia Gomez-Ospina et al.   Nature Communications

Combined ursodeoxycholic acid (UDCA) and fenofibrate in primary biliary cholangitis patients with incomplete UDCA response may improve outcomes

(2015) A. C. Cheung et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

(2015) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

(2015) Maria Reich et al.   GUT

Targeted pharmacotherapy in progressive familial intrahepatic cholestasis type 2: Evidence for improvement of cholestasis with 4-phenylbutyrate

(2015) Emmanuel Gonzales et al.   HEPATOLOGY

Fibrates and cholestasis

(2015) Nisanne S. Ghonem et al.   HEPATOLOGY

Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice

(2015) Alexander G. Miethke et al.   HEPATOLOGY

Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na+-taurocholate cotransporting polypeptide knockout mice

(2015) Davor Slijepcevic et al.   HEPATOLOGY

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2 -deficient mice

(2015) Mei Zhou et al.   HEPATOLOGY

Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension

(2015) Rajeshwar P. Mookerjee et al.   JOURNAL OF HEPATOLOGY

Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

(2015) Michaela Mueller et al.   JOURNAL OF HEPATOLOGY

New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

(2015) Ulrich Beuers et al.   JOURNAL OF HEPATOLOGY

Bile Acid Pool Dynamics in Progressive Familial Intrahepatic Cholestasis With Partial External Bile Diversion

(2015) Hilary S. Jericho et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

(2015) Chiara Degirolamo et al.   NATURE REVIEWS DRUG DISCOVERY

Novel therapeutic targets in primary biliary cirrhosis

(2015) Jessica K. Dyson et al.   Nature Reviews Gastroenterology & Hepatology

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease

(2015) Ewa Wunsch et al.   Scientific Reports

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

(2014) M. Zhou et al.   CANCER RESEARCH

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype

(2014) Frédéric M. Vaz et al.   HEPATOLOGY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted inhibition of the FGF19-FGFR4 pathway in hepatocellular carcinoma; translational safety considerations

(2014) Howard R. Mellor   LIVER INTERNATIONAL

A nontumorigenic variant of FGF19 treats cholestatic liver diseases

(2014) J. Luo et al.   Science Translational Medicine

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

(2013) Noémie Péan et al.   HEPATOLOGY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes

(2012) Holger Gohlke et al.   HEPATOLOGY

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

(2012) Emina Halilbasic et al.   JOURNAL OF HEPATOLOGY

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

(2012) Tassilo Volz et al.   JOURNAL OF HEPATOLOGY

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

(2011) Salvatore Modica et al.   GASTROENTEROLOGY

A biliary HCO3−umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes

(2011) Simon Hohenester et al.   HEPATOLOGY

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches

(2010) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

The potent bile acid sequestrant colesevelam is not effective in cholestatic pruritus: Results of a double-blind, randomized, placebo-controlled trial

(2010) Edith M. M. Kuiper et al.   HEPATOLOGY

Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

(2009) Tom H. Karlsen et al.   GASTROENTEROLOGY

Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice

(2009) Emina Halilbasic et al.   HEPATOLOGY

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Severe Bile Salt Export Pump Deficiency: 82 Different ABCB11 Mutations in 109 Families

(2008) Sandra S. Strautnieks et al.   GASTROENTEROLOGY

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

(2008) Frank G. Schaap et al.   HEPATOLOGY

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures

(2008) Carlijn I. Buis et al.   JOURNAL OF HEPATOLOGY