Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure

Albumin in decompensated cirrhosis: new concepts and perspectives

(2020) Mauro Bernardi et al.   GUT

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Sadaf G Sepanlou et al.   Lancet Gastroenterology & Hepatology

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

(2020) Sara Vieira-Silva et al.   NATURE

Acute-on-Chronic Liver Failure

(2020) Vicente Arroyo et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis

(2020) Tae Gyu Oh et al.   Cell Metabolism

Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease

(2020) Sonja Lang et al.   GASTROENTEROLOGY

Serum Levels of Metabolites Produced by Intestinal Microbes and Lipid Moieties Independently Associated With Acute on Chronic Liver Failure and Death in Patients With Cirrhosis

(2020) Jasmohan S. Bajaj et al.   GASTROENTEROLOGY

The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology

(2020) Jonel Trebicka et al.   JOURNAL OF HEPATOLOGY

A unified catalog of 204,938 reference genomes from the human gut microbiome

(2020) Alexandre Almeida et al.   NATURE BIOTECHNOLOGY

Long-term Outcomes after Fecal Microbiota Transplant in Cirrhosis

(2019) Jasmohan S. Bajaj et al.   GASTROENTEROLOGY

Alcohol, liver disease and the gut microbiota

(2019) Jasmohan S. Bajaj   Nature Reviews Gastroenterology & Hepatology

Characterization of the Circulating Microbiome in Acute-on-chronic Liver Failure Associated with Hepatitis B

(2019) Yi Zhang et al.   LIVER INTERNATIONAL

Alcohol-associated liver disease, not hepatitis B, is the major cause of cirrhosis in Asia

(2019) Shivaram Prasad Singh et al.   JOURNAL OF HEPATOLOGY

Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis

(2019) Javier Fernández et al.   GASTROENTEROLOGY

Gut microbiota in liver disease: Too much is harmful, nothing at all is not helpful either

(2019) Phillipp Hartmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fecal Microbial Transplant Capsules are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial

(2019) Jasmohan S Bajaj et al.   HEPATOLOGY

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation

(2019) Andrew Maltez Thomas et al.   NATURE MEDICINE

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

(2019) Jakob Wirbel et al.   NATURE MEDICINE

Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS

(2019) Alexander Queck et al.   GUT

FxR-modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis

(2019) M. Sorribas et al.   JOURNAL OF HEPATOLOGY

Circulating Microbiota-Based Metagenomic Signature for Detection of Hepatocellular Carcinoma

(2019) Eun Ju Cho et al.   Scientific Reports

Efficacy of Albumin Treatment for Patients with Cirrhosis and Infections Unrelated to Spontaneous Bacterial Peritonitis

(2019) Javier Fernández et al.   Clinical Gastroenterology and Hepatology

Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

(2019) Richard Moreau et al.   JOURNAL OF HEPATOLOGY

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

(2019) Zachariah DeFilipp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial

(2019) Elisa Pose et al.   Lancet Gastroenterology & Hepatology

Diurnal variations in intestinal barrier integrity and liver pathology in mice: implications for alcohol binge

(2018) Robin M. Voigt et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Human Gut Microbiome: From Association to Modulation

(2018) Thomas S.B. Schmidt et al.   CELL

Association Between Intestinal Microbiota Collected at Hospital Admission and Outcomes of Patients with Cirrhosis

(2018) Jasmohan S. Bajaj et al.   Clinical Gastroenterology and Hepatology

Selective maternal seeding and environment shape the human gut microbiome

(2018) Katri Korpela et al.   GENOME RESEARCH

Circulating microbiome in blood of different circulatory compartments

(2018) Robert Schierwagen et al.   GUT

Increase in liver stiffness after transjugular intrahepatic portosystemic shunt is associated with inflammation and predicts mortality

(2018) Christian Jansen et al.   HEPATOLOGY

The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

(2018) Puneet Puri et al.   HEPATOLOGY

Cell death markers in patients with cirrhosis and acute decompensation

(2018) Stewart Macdonald et al.   HEPATOLOGY

NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis

(2018) Jacqueline G. O'Leary et al.   HEPATOLOGY

Diet affects gut microbiota and modulates hospitalization risk differentially in an international cirrhosis cohort

(2018) Jasmohan S. Bajaj et al.   HEPATOLOGY

EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis

(2018) Paolo Angeli et al.   JOURNAL OF HEPATOLOGY

Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial

(2018) Paolo Caraceni et al.   LANCET

The gut–liver axis and the intersection with the microbiome

(2018) Anupriya Tripathi et al.   Nature Reviews Gastroenterology & Hepatology

Periodontal Therapy Favorably Modulates the Oral-Gut-Hepatic Axis in Cirrhosis

(2018) Jasmohan Singh Bajaj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma

(2018) Zhigang Ren et al.   GUT

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

(2018) Maurizio Parola et al.   MOLECULAR ASPECTS OF MEDICINE

Extensive impact of non-antibiotic drugs on human gut bacteria

(2018) Lisa Maier et al.   NATURE

Simvastatin Prevents Progression of Acute on Chronic Liver Failure in Rats With Cirrhosis and Portal Hypertension

(2018) Dinesh Mani Tripathi et al.   GASTROENTEROLOGY

Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide

(2018) Salvatore Piano et al.   GASTROENTEROLOGY

Changing Trends in Etiology-Based Annual Mortality From Chronic Liver Disease, From 2007 Through 2016

(2018) Donghee Kim et al.   GASTROENTEROLOGY

Effects of Long-term Norfloxacin Therapy in Patients With Advanced Cirrhosis

(2018) Richard Moreau et al.   GASTROENTEROLOGY

Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis

(2018) Leticia Muñoz et al.   HEPATOLOGY

Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe

(2018) Javier Fernández et al.   JOURNAL OF HEPATOLOGY

Gut Microbiota and Complications of Liver Disease

(2017) Chathur Acharya et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Fungal dysbiosis in cirrhosis

(2017) Jasmohan S Bajaj et al.   GUT

Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis

(2017) Javier Fernández et al.   GUT

Acute-on-chronic liver failure: an update

(2017) Ruben Hernaez et al.   GUT

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

(2017) Jasmohan S. Bajaj et al.   HEPATOLOGY

Intestinal fungi contribute to development of alcoholic liver disease

(2017) An-Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Rifaximin has minor effects on bacterial composition, inflammation, and bacterial translocation in cirrhosis: A randomized trial

(2017) Nina Kimer et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Targeting the gut-liver axis in liver disease

(2017) Reiner Wiest et al.   JOURNAL OF HEPATOLOGY

Emergency TIPS in a Child-Pugh B patient: When does the window of opportunity open and close?

(2017) Jonel Trebicka   JOURNAL OF HEPATOLOGY

Circulating CXCL10 in cirrhotic portal hypertension might reflect systemic inflammation and predict ACLF and mortality

(2017) Jennifer M. Lehmann et al.   LIVER INTERNATIONAL

Liver transplant modulates gut microbial dysbiosis and cognitive function in cirrhosis

(2017) Jasmohan S. Bajaj et al.   LIVER TRANSPLANTATION

Accessible, curated metagenomic data through ExperimentHub

(2017) Edoardo Pasolli et al.   NATURE METHODS

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

The Human Gut Microbiome in Liver Diseases

(2017) Brian Davis et al.   SEMINARS IN LIVER DISEASE

Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

(2017) Cristina Llorente et al.   Nature Communications

Meta-analysis of gut microbiome studies identifies disease-specific and shared responses

(2017) Claire Duvallet et al.   Nature Communications

Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease

(2017) Veronika B. Dubinkina et al.   Microbiome

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation

(2016) Lirui Wang et al.   Cell Host & Microbe

Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis

(2016) Juan G. Abraldes et al.   GASTROENTEROLOGY

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

Proton pump inhibitors as a risk factor for hepatic encephalopathy and spontaneous bacterial peritonitis in patients with cirrhosis with ascites

(2016) Gitte Dam et al.   HEPATOLOGY

Antibiotic prophylaxis in cirrhosis: Good and bad

(2016) Javier Fernández et al.   HEPATOLOGY

Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure

(2016) Joan Clària et al.   HEPATOLOGY

Rifaximin has no effect on hemodynamics in decompensated cirrhosis: A randomized, double-blind, placebo-controlled trial

(2016) Nina Kimer et al.   HEPATOLOGY

Heavy daily alcohol intake at the population level predicts the weight of alcohol in cirrhosis burden worldwide

(2016) Eva Stein et al.   JOURNAL OF HEPATOLOGY

Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats

(2016) María Úbeda et al.   JOURNAL OF HEPATOLOGY

Acute-on-chronic liver failure: terminology, mechanisms and management

(2016) Shiv K. Sarin et al.   Nature Reviews Gastroenterology & Hepatology

Treatment of Patients with Cirrhosis

(2016) Phillip S. Ge et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidemiology and Healthcare Burden of Acute-on-Chronic Liver Failure

(2016) Alina Allen et al.   SEMINARS IN LIVER DISEASE

Predisposing Factors in Acute-on-Chronic Liver Failure

(2016) Jonel Trebicka   SEMINARS IN LIVER DISEASE

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Acute-on-chronic liver failure in cirrhosis

(2016) Vicente Arroyo et al.   Nature Reviews Disease Primers

Characteristics and Discrepancies in Acute-on-Chronic Liver Failure: Need for a Unified Definition

(2016) Tae Yeob Kim et al.   PLoS One

Characteristics, Diagnosis and Prognosis of Acute-on-Chronic Liver Failure in Cirrhosis Associated to Hepatitis B.

(2016) Hai Li et al.   Scientific Reports

Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases

(2015) R. B. Sartor   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The FXR Agonist Obeticholic Acid Prevents Gut Barrier Dysfunction and Bacterial Translocation in Cholestatic Rats

(2015) Len Verbeke et al.   AMERICAN JOURNAL OF PATHOLOGY

Gut Microbiota, Cirrhosis, and Alcohol Regulate Bile Acid Metabolism in the Gut

(2015) Jason M. Ridlon et al.   DIGESTIVE DISEASES

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

(2015) Jun Yu et al.   GUT

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease

(2015) M Llopis et al.   GUT

Acute-on-chronic liver failure precipitated by hepatic injury is distinct from that precipitated by extrahepatic insults

(2015) Yu Shi et al.   HEPATOLOGY

Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy

(2015) Jasmohan S. Bajaj et al.   HEPATOLOGY

Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: Results of a longitudinal study

(2015) Filipe Nery et al.   HEPATOLOGY

Gut dysbiosis in acute-on-chronic liver failure and its predictive value for mortality

(2015) Yanfei Chen et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Effect of albumin in cirrhotic patients with infection other than spontaneous bacterial peritonitis. A randomized trial

(2015) Thierry Thévenot et al.   JOURNAL OF HEPATOLOGY

The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure

(2015) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Decompensated cirrhosis and microbiome interpretation

(2015) Jasmohan S. Bajaj et al.   NATURE

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis

(2015) Jan Görtzen et al.   Frontiers in Physiology

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

(2014) Genta Kakiyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The global burden of liver disease: a challenge for methods and for public health

(2014) Peter Byass   BMC Medicine

Probiotic VSL#3 Reduces Liver Disease Severity and Hospitalization in Patients With Cirrhosis: A Randomized, Controlled Trial

(2014) Radha K. Dhiman et al.   GASTROENTEROLOGY

Posttranscriptional changes of serum albumin: Clinical and prognostic significance in hospitalized patients with cirrhosis

(2014) Marco Domenicali et al.   HEPATOLOGY

Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures

(2014) Jasmohan S. Bajaj et al.   HEPATOLOGY

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014

(2014) Shiv Kumar Sarin et al.   Hepatology International

Liver cirrhosis

(2014) Emmanuel A Tsochatzis et al.   LANCET

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

An integrated catalog of reference genes in the human gut microbiome

(2014) Junhua Li et al.   NATURE BIOTECHNOLOGY

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

(2014) Alastair J O'Brien et al.   NATURE MEDICINE

Antibiotics in early life and obesity

(2014) Laura M. Cox et al.   Nature Reviews Endocrinology

Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals

(2014) Shashi Bala et al.   PLoS One

Impact of Rifaximin on the Frequency and Characteristics of Spontaneous Bacterial Peritonitis in Patients with Liver Cirrhosis and Ascites

(2014) Philipp Lutz et al.   PLoS One

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

(2013) Richard Moreau et al.   GASTROENTEROLOGY

Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice

(2013) Phillipp Hartmann et al.   HEPATOLOGY

Activated intestinal macrophages in patients with cirrhosis release NO and IL-6 that may disrupt intestinal barrier function

(2013) Johannie Du Plessis et al.   JOURNAL OF HEPATOLOGY

Altered profile of human gut microbiome is associated with cirrhosis and its complications

(2013) Jasmohan S. Bajaj et al.   JOURNAL OF HEPATOLOGY

Soluble TNF-Alpha-Receptors I Are Prognostic Markers in TIPS-Treated Patients with Cirrhosis and Portal Hypertension

(2013) Jonel Trebicka et al.   PLoS One

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

(2012) Jasmohan S. Bajaj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Rifaximin Improves Systemic Hemodynamics and Renal Function in Patients With Alcohol-Related Cirrhosis and Ascites

(2012) Georgios N. Kalambokis et al.   Clinical Gastroenterology and Hepatology

Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis

(2012) Erica Villa et al.   GASTROENTEROLOGY

Systematic review and meta-analysis of randomized trials on probiotics for hepatic encephalopathy

(2012) Kathrine Holte et al.   HEPATOLOGY RESEARCH

Long-term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis

(2012) Jiannis Vlachogiannakos et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. A randomized, controlled study

(2012) Mónica Guevara et al.   JOURNAL OF HEPATOLOGY

Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis

(2012) Thomas Reiberger et al.   JOURNAL OF HEPATOLOGY

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Spontaneous bacterial peritonitis: recent guidelines and beyond

(2011) R Wiest et al.   GUT

Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense

(2011) Zora Teltschik et al.   HEPATOLOGY

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Hepatic venous pressure gradient in 2010: Optimal measurement is key

(2010) Andrew K. Burroughs et al.   HEPATOLOGY

Acute endotoxemia following transjugular intrahepatic stent-shunt insertion is associated with systemic and cerebral vasodilatation with increased whole body nitric oxide production in critically ill cirrhotic patients

(2010) R. Jalan et al.   JOURNAL OF HEPATOLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Rifaximin Treatment in Hepatic Encephalopathy

(2010) Nathan M. Bass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Propranolol Decreases Intestinal Permeability in Patients With Cirrhosis: Another Protective Mechanism Against Bleeding?

(2009) Marco Senzolo et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial

(2009) Juan G. Abraldes et al.   GASTROENTEROLOGY

Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality

(2009) Rajiv Jalan et al.   HEPATOLOGY

β-Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis

(2009) Marco Senzolo et al.   LIVER INTERNATIONAL