Mucosal immunity in primary sclerosing cholangitis: from the bowel to bile ducts and back again

Identification of an Anti–Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis

(2021) Takeshi Kuwada et al.   GASTROENTEROLOGY

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4+ T cells in primary sclerosing cholangitis

(2021) Tobias Poch et al.   JOURNAL OF HEPATOLOGY

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

(2021) Maria Reich et al.   JOURNAL OF HEPATOLOGY

Recent advances in clinical practice: epidemiology of autoimmune liver diseases

(2021) Palak J Trivedi et al.   GUT

A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells

(2021) Christine L. Zimmer et al.   Science Translational Medicine

Emerging drugs for the treatment of primary sclerosing cholangitis

(2021) Nadir Abbas et al.   CURRENT OPINION IN PHARMACOLOGY

Monocytes as potential mediators of pathogen‐induced Th17 differentiation in patients with primary sclerosing cholangitis (PSC)

(2020) Lilly Kristin Kunzmann et al.   HEPATOLOGY

A pilot integrative analysis of colonic gene expression, gut microbiota and immune infiltration in primary sclerosing cholangitis-inflammatory bowel disease: association of disease with bile acid pathways

(2020) Mohammed Nabil Quraishi et al.   Journal of Crohns & Colitis

Effects of Primary Sclerosing Cholangitis on Risks of Cancer and Death in People With Inflammatory Bowel Diseases, Based on Sex, Race, and Age

(2020) Palak J. Trivedi et al.   GASTROENTEROLOGY

A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis

(2020) Kris V. Kowdley et al.   JOURNAL OF HEPATOLOGY

Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor

(2020) Raffaella Maria Gadaleta et al.   EBioMedicine

Oral vancomycin, ursodeoxycholic acid or no therapy for pediatric primary sclerosing cholangitis: a matched analysis

(2020) Mark R. Deneau   HEPATOLOGY

Prevalence and long‐term outcome of sub‐clinical primary sclerosing cholangitis in patients with ulcerative colitis

(2020) Emma L Culver et al.   LIVER INTERNATIONAL

Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis

(2020) Martin Kummen et al.   GASTROENTEROLOGY

The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC

(2019) Michael Trauner et al.   HEPATOLOGY

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

(2019) Nobuhiro Nakamoto et al.   Nature Microbiology

TGR5-dependent hepatoprotection through the regulation of biliary epithelium barrier function

(2019) Grégory Merlen et al.   GUT

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

(2019) Lijun Liao et al.   GUT

CCL21-expression and accumulation of CCR7+ NK cells in livers of patients with primary sclerosing cholangitis

(2019) Annika E. Langeneckert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systematic review with meta-analysis: risk factors for recurrent primary sclerosing cholangitis after liver transplantation

(2019) Iris C. Steenstraten et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis

(2019) Sara Lemoinne et al.   GUT

Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis

(2019) Malte Rühlemann et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis

(2019) Jessica R. Allegretti et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Alterations of the bile microbiome in primary sclerosing cholangitis

(2019) Timur Liwinski et al.   GUT

Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice

(2019) Gevitha Ravichandran et al.   JOURNAL OF HEPATOLOGY

Effects of Antibiotic Therapy in Primary Sclerosing Cholangitis with and without Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

(2019) Ayesha Shah et al.   SEMINARS IN LIVER DISEASE

Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases

(2019) Hannah C. Jeffery et al.   JOURNAL OF IMMUNOLOGY

Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species

(2019) Malte Christoph Rühlemann et al.   GUT

The impact of ileal pouch-anal anastomosis on graft survival following liver transplantation for primary sclerosing cholangitis

(2018) P. J. Trivedi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease

(2018) Dana Tedesco et al.   GASTROENTEROLOGY

MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation

(2018) Katrin Böttcher et al.   HEPATOLOGY

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

(2018) Maria Eugenia Guicciardi et al.   JOURNAL OF HEPATOLOGY

Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker

(2018) Kentaro Iwasawa et al.   Scientific Reports

Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells

(2018) Erik von Seth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis

(2018) Amandeep K Dhillon et al.   LIVER INTERNATIONAL

Natural killer T cells mediate inflammation in the bile ducts

(2018) N. L. Berntsen et al.   Mucosal Immunology

Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial

(2018) Gideon M. Hirschfield et al.   JOURNAL OF HEPATOLOGY

M1-Polarized Macrophages Promote Self-Renewing Phenotype of Hepatic Progenitor Cells with Jagged1-Notch Signalling Involved: Relevance in Primary Sclerosing Cholangitis

(2018) Heli Li et al.   Journal of Immunology Research

Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner

(2017) Palak J Trivedi et al.   GUT

Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease

(2017) Antonio Riva et al.   GUT

Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related to IL-12 signaling

(2017) Dorothee Schwinge et al.   JOURNAL OF HEPATOLOGY

nor Ursodeoxycholic acid improves cholestasis in primary sclerosing cholangitis

(2017) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease

(2017) Eva Kristine Klemsdal Henriksen et al.   JOURNAL OF HEPATOLOGY

The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation

(2017) Elisabeth Schrumpf et al.   JOURNAL OF HEPATOLOGY

Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis

(2017) Lukas Bajer et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease

(2017) J Torres et al.   United European Gastroenterology Journal

Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score

(2017) Hannah C. Jeffery et al.   PLoS One

The features of mucosa-associated microbiota in primary sclerosing cholangitis

(2016) J. Torres et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy

(2016) Julia Hengst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The gut-adherent microbiota of PSC–IBD is distinct to that of IBD

(2016) Mohammed Nabil Quraishi et al.   GUT

Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD

(2016) João Sabino et al.   GUT

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

(2016) Martin Kummen et al.   GUT

Gut–liver immunity

(2016) Palak J. Trivedi et al.   JOURNAL OF HEPATOLOGY

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

(2016) Hannah C. Jeffery et al.   JOURNAL OF HEPATOLOGY

CD4 + T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood

(2016) Tanja Schoknecht et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

(2015) Zhen-Wei Peng et al.   HEPATOLOGY

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

(2015) James H. Tabibian et al.   HEPATOLOGY

The biliary epithelium presents antigens to and activates natural killer T cells

(2015) Elisabeth Schrumpf et al.   HEPATOLOGY

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires

(2015) Evaggelia Liaskou et al.   HEPATOLOGY

Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis

(2015) D. Kevans et al.   Journal of Crohns & Colitis

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

Fucosyltransferase 2: A Genetic Risk Factor for Primary Sclerosing Cholangitis and Crohn's Disease—A Comprehensive Review

(2014) Luca Maroni et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Loss of CD28 Expression by Liver-Infiltrating T Cells Contributes to Pathogenesis of Primary Sclerosing Cholangitis

(2014) Evaggelia Liaskou et al.   GASTROENTEROLOGY

The Mucosa-associated Microbiota of PSC Patients is Characterized by Low Diversity and Low Abundance of Uncultured Clostridiales II

(2014) Noortje G. Rossen et al.   Journal of Crohns & Colitis

Influence of CD8 T cell priming in liver and gut on the enterohepatic circulation

(2014) Ira Eickmeier et al.   JOURNAL OF HEPATOLOGY

Reduced FOXP3+ regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms

(2014) Marcial Sebode et al.   JOURNAL OF HEPATOLOGY

In Situ Characterization of Intrahepatic Non-Parenchymal Cells in PSC Reveals Phenotypic Patterns Associated with Disease Severity

(2014) Lena Berglin et al.   PLoS One

Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis

(2014) H. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice

(2013) Daniel Seidel et al.   HEPATOLOGY

Increased T helper type 17 response to pathogen stimulation in patients with primary sclerosing cholangitis

(2013) Janosch Katt et al.   HEPATOLOGY

Mucosal immunity in liver autoimmunity: A comprehensive review

(2013) Palak J. Trivedi et al.   JOURNAL OF AUTOIMMUNITY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

(2012) Ye Htun Oo et al.   JOURNAL OF HEPATOLOGY

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity

(2010) Evaggelia Liaskou et al.   HEPATOLOGY

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14+CD16+ Monocytes to Inflammation and Human Liver Fibrosis

(2010) Henning W. Zimmermann et al.   PLoS One