Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

TMAVA, a Metabolite of Intestinal Microbes, Is Increased in Plasma From Patients With Liver Steatosis, Inhibits γ-butyrobetaine Hydroxylase, and Exacerbates Fatty Liver in Mice

(2020) Mingming Zhao et al.   GASTROENTEROLOGY

Lactococcus Lactis subsp. cremoris Elicits Protection Against Metabolic Changes Induced by a Western-style Diet

(2020) Crystal R. Naudin et al.   GASTROENTEROLOGY

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Interactions between gut microbiota and non-alcoholic liver disease: the role of microbiota-derived metabolites

(2019) Yufang Ding et al.   PHARMACOLOGICAL RESEARCH

Notch and Nonalcoholic Fatty Liver and Fibrosis

(2019) Stefano Romeo   NEW ENGLAND JOURNAL OF MEDICINE

High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine

(2018) M. R. Panasevich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bile Acid Metabolism in Liver Pathobiology

(2018) John Y. L. Chiang et al.   GENE EXPRESSION

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

(2018) Dabin Liu et al.   Science Translational Medicine

Dynamic alterations in the gut microbiota and metabolome during the development of methionine-choline-deficient diet-induced nonalcoholic steatohepatitis

(2018) Jian-Zhong Ye et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease

(2018) Fasiha Kanwal et al.   GASTROENTEROLOGY

Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages

(2018) Brett McGettigan et al.   HEPATOLOGY

Dietary cholesterol promotes steatohepatitis related hepatocellular carcinoma through dysregulated metabolism and calcium signaling

(2018) Jessie Qiaoyi Liang et al.   Nature Communications

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

(2017) Dylan Dodd et al.   NATURE

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE 2 -Mediated Suppression of Antitumor Immunity

(2017) Tze Mun Loo et al.   Cancer Discovery

Relative variations of gut microbiota in disordered cholesterol metabolism caused by high-cholesterol diet and host genetics

(2017) Tao Bo et al.   MicrobiologyOpen

Lifestyle and Horizontal Gene Transfer-Mediated Evolution of Mucispirillum schaedleri , a Core Member of the Murine Gut Microbiota

(2017) Alexander Loy et al.   mSystems

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

(2016) J-Y Yang et al.   Mucosal Immunology

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

(2015) Siegfried Ussar et al.   Cell Metabolism

Implication of Gut Microbiota in Nonalcoholic Fatty Liver Disease

(2015) Jerome Boursier et al.   PLoS Pathogens

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis

(2014) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease

(2014) Kouichi Miura   WORLD JOURNAL OF GASTROENTEROLOGY

Lactobacillus casei strain Shirota protects against nonalcoholic steatohepatitis development in a rodent model

(2013) Hirofumi Okubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Nonalcoholic steatohepatitis is the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the U.S.

(2013) Robert J. Wong et al.   HEPATOLOGY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Structural resilience of the gut microbiota in adult mice under high-fat dietary perturbations

(2012) Chenhong Zhang et al.   ISME Journal

Bacteroides uniformis CECT 7771 Ameliorates Metabolic and Immunological Dysfunction in Mice with High-Fat-Diet Induced Obesity

(2012) Paola Gauffin Cano et al.   PLoS One

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY