β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes

(2016) Benjamin A. Kandel et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Farnesoid X Receptor Agonists and Other Bile Acid Signaling Strategies for Treatment of Liver Disease

(2016) Emina Halilbasic et al.   DIGESTIVE DISEASES

Obeticholic Acid: First Global Approval

(2016) A. Markham et al.   DRUGS

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of gene expression by CAR: an update

(2015) Kaoru Kobayashi et al.   ARCHIVES OF TOXICOLOGY

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

(2015) Maria Thomas et al.   BMC CANCER

Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice

(2015) Kerstin Abshagen et al.   BMC Systems Biology

The Anti-Microbial Peptide LL-37/CRAMP Is Elevated in Patients with Liver Diseases and Acts as a Protective Factor during Mouse Liver Injury

(2015) Svenja Wertenbruch et al.   DIGESTION

Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid

(2015) Gideon M. Hirschfield et al.   GASTROENTEROLOGY

Fibrates and cholestasis

(2015) Nisanne S. Ghonem et al.   HEPATOLOGY

LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods

(2015) Ronny Feuer et al.   PLoS One

Crohn's disease-derived monocytes fail to induce Paneth cell defensins

(2015) Lioba F. Courth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

(2015) Maria Thomas et al.   Frontiers in Pharmacology

Changes in gut bacterial populations and their translocation into liver and ascites in alcoholic liver cirrhotics

(2014) Sari Tuomisto et al.   BMC GASTROENTEROLOGY

Targeting Nuclear Receptors with Lentivirus-Delivered Small RNAs in Primary Human Hepatocytes

(2014) Maria Thomas et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Bacterial translocation in liver cirrhosis: Site and role in fibrogenesis

(2014) Claude Matuchansky   JOURNAL OF HEPATOLOGY

Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study

(2013) Tao Wu et al.   BMC GENOMICS

Antimicrobial peptides and gut microbiota in homeostasis and pathology

(2013) Maureen J. Ostaff et al.   EMBO Molecular Medicine

Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

(2013) Samuele De Minicis et al.   HEPATOLOGY

Pathological bacterial translocation in liver cirrhosis

(2013) Reiner Wiest et al.   JOURNAL OF HEPATOLOGY

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin

(2013) S U Jaeger et al.   Mucosal Immunology

Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense

(2011) Zora Teltschik et al.   HEPATOLOGY

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

(2011) Ekihiro Seki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver

(2011) A Schröder et al.   PHARMACOGENOMICS JOURNAL

Hepcidin Is an Antibacterial, Stress-Inducible Peptide of the Biliary System

(2011) Pavel Strnad et al.   PLoS One

Biliary Innate Immunity: Function and Modulation

(2010) Kenichi Harada et al.   MEDIATORS OF INFLAMMATION

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

(2010) L. Peyrin-Biroulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

(2009) Anne T. Nies et al.   HEPATOLOGY

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

(2009) Ana M Gomes et al.   PHARMACOGENOMICS

Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium

(2008) Emilie D'Aldebert et al.   GASTROENTEROLOGY