FXR agonists for NASH: How are they different and what difference do they make?

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

(2021) Lulu Sun et al.   Nature Reviews Gastroenterology & Hepatology

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus

(2019) James Meixiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF19–FGFR4 Signaling in Hepatocellular Carcinoma

(2019) Aroosha Raja et al.   Cells

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice

(2017) Jan Freark de Boer et al.   GASTROENTEROLOGY

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

(2017) Philipp Schwabl et al.   JOURNAL OF HEPATOLOGY

Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils

(2016) Todd G. Kirchgessner et al.   Cell Metabolism

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Knocking on FXR's Door:The "Hammerhead"-Structure Series of FXRs Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities

(2014) Christian Gege et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal

(2014) Johannes Schmitt et al.   LIVER INTERNATIONAL

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice

(2013) Yanjun Jiang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Clinical application of transcriptional activators of bile salt transporters

(2013) Anna Baghdasaryan et al.   MOLECULAR ASPECTS OF MEDICINE

Bile Acid Receptor Agonist GW4064 Regulates PPARγ Coactivator-1α Expression Through Estrogen Receptor-Related Receptor α

(2011) Shailendra Kumar Dhar Dwivedi et al.   MOLECULAR ENDOCRINOLOGY