Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

GASTROLITHIASIS IN PREHENSILE-TAILED PORCUPINES (COENDOU PREHENSILIS): NINE CASES AND PATHOGENESIS OF STONE FORMATION

(2015) Maria Spriggs et al.   JOURNAL OF ZOO AND WILDLIFE MEDICINE

A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS

(2014) Genta Kakiyama et al.   JOURNAL OF LIPID RESEARCH

Chenodeoxycholic acid stimulates Cl− secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells

(2013) Mei Ao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11−/− mouse: transport and gene expression studies

(2013) Renxue Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bowel Functions, Fecal Unconjugated Primary and Secondary Bile Acids, and Colonic Transit in Patients With Irritable Bowel Syndrome

(2013) Andrea Shin et al.   Clinical Gastroenterology and Hepatology

Methods for Diagnosis of Bile Acid Malabsorption in Clinical Practice

(2013) Priya Vijayvargiya et al.   Clinical Gastroenterology and Hepatology

TGR5 in cholangiocytes

(2013) Verena Keitel et al.   CURRENT OPINION IN GASTROENTEROLOGY

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

(2013) Iker Uriarte et al.   GUT

Genotype-phenotype relationships in the low-phospholipid-associated cholelithiasis syndrome: A study of 156 consecutive patients

(2013) Raoul Poupon et al.   HEPATOLOGY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential effects of norUDCA and UDCA in obstructive cholestasis in mice

(2013) Peter Fickert et al.   JOURNAL OF HEPATOLOGY

FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels

(2013) Quan Shang et al.   JOURNAL OF LIPID RESEARCH

In celebration of the 100th anniversary of the lipid hypothesis of atherosclerosis

(2013) Daniel Steinberg   JOURNAL OF LIPID RESEARCH

Ursodeoxycholic acid attenuates colonic epithelial secretory function

(2013) Orlaith B. Kelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

The SLCO (former SLC21) superfamily of transporters

(2013) Bruno Hagenbuch et al.   MOLECULAR ASPECTS OF MEDICINE

N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): A novel bile acid profile in Perciform fish

(2013) Rika Satoh (née Okihara) et al.   STEROIDS

Microbial Biotransformations of Bile Acids as Detected by Electrospray Mass Spectrometry

(2013) Lee R. Hagey et al.   Advances in Nutrition

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Structural requirements of bile acid transporters: C-3 and C-7 modifications of steroidal hydroxyl groups

(2012) Vidula Kolhatkar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

Monitoring bile acid transport in single living cells using a genetically encoded Förster resonance energy transfer sensor

(2012) Lieke M. van der Velden et al.   HEPATOLOGY

Abcb11Deficiency Induces Cholestasis Coupled to Impaired β-Fatty Acid Oxidation in Mice

(2012) Yuanyuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

(2012) Geoffrey Porez et al.   JOURNAL OF LIPID RESEARCH

[N-Methyl-11C]Cholylsarcosine, a Novel Bile Acid Tracer for PET/CT of Hepatic Excretory Function: Radiosynthesis and Proof-of-Concept Studies in Pigs

(2012) K. Frisch et al.   JOURNAL OF NUCLEAR MEDICINE

FXR signaling in the enterohepatic system

(2012) Tsutomu Matsubara et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10 −/− mice

(2012) Suzanne Devkota et al.   NATURE

A novel varanic acid epimer – (24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid – is a major biliary bile acid in two varanid lizards and the Gila monster

(2012) Lee R. Hagey et al.   STEROIDS

Randomised clinical trial: the ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation - a double-blind study

(2011) M. Simrén et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes

(2011) Lihong Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates

(2011) Shoujiro Ogawa et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Farnesoid X receptor agonists for primary biliary cirrhosis

(2011) Keith D Lindor   CURRENT OPINION IN GASTROENTEROLOGY

Molecular Mechanisms of Altered Bile Acid Homeostasis in Organic Solute Transporter-Alpha Knockout Mice

(2011) Tian Lan et al.   DIGESTIVE DISEASES

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Interview with Dr. Scott Grundy during AHA EPI/NPAM Meeting in March 2011

(2011) Darren K. McGuire et al.   Journal of Clinical Lipidology

Disorders of bile acid synthesis

(2011) Peter Theodore Clayton   JOURNAL OF INHERITED METABOLIC DISEASE

Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT

(2011) Nien-Jen Hu et al.   NATURE

Biliary bile acids in birds of the Cotingidae family: Taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid

(2011) Lee R. Hagey et al.   STEROIDS

Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS

(2011) Kuniko Mitamura et al.   STEROIDS

Cholestasis and the Role of Basolateral Efflux Pumps

(2011) D. Keppler   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Complex Evolution of Bile Salts in Birds

(2010) Lee R. Hagey et al.   AUK

Hepatobiliary Disposition of 3 ,6 ,7 ,12 -Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters

(2010) V. Megaraj et al.   DRUG METABOLISM AND DISPOSITION

Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice

(2010) Iván L. Csanaky et al.   HEPATOLOGY

Unconjugated bile salts shuttle through hepatocyte peroxisomes for taurine conjugation

(2010) Krzysztof P. Rembacz et al.   HEPATOLOGY

Altered Bile Acid Metabolism in Childhood Functional Constipation: Inactivation of Secretory Bile Acids by Sulfation in a Subset of Patients

(2010) Alan F Hofmann et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Organic Solute Transporter, OSTα-OSTβ: Its Role in Bile Acid Transport and Cholestasis

(2010) Carol Soroka et al.   SEMINARS IN LIVER DISEASE

Diagnostic Performance of Traditional Hepatobiliary Biomarkers of Drug-Induced Liver Injury in the Rat

(2010) Daniela Ennulat et al.   TOXICOLOGICAL SCIENCES

Managing bile acid diarrhoea

(2010) Julian R. F. Walters et al.   Therapeutic Advances in Gastroenterology

Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome

(2009) L. WEDLAKE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Novel Bile Acids from Bear Bile Powder and Bile of Geese

(2009) Dan Bi et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

(2009) Julian R.F. Walters et al.   Clinical Gastroenterology and Hepatology

Compensatory role of P-glycoproteins in knockout mice lacking the bile salt export pump

(2009) Renxue Wang et al.   HEPATOLOGY

Developments in bile acid kinetic measurements using13C and2H: 105times improved sensitivity during the last 40 years†

(2009) Frans Stellaard et al.   ISOTOPES IN ENVIRONMENTAL AND HEALTH STUDIES

Bile acids: analysis in biological fluids and tissues

(2009) William J. Griffiths et al.   JOURNAL OF LIPID RESEARCH

Bile acids: regulation of apoptosis by ursodeoxycholic acid

(2009) Joana D. Amaral et al.   JOURNAL OF LIPID RESEARCH

Bile salts of vertebrates: structural variation and possible evolutionary significance

(2009) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Regulation of direct transintestinal cholesterol excretion in mice

(2008) Astrid E. van der Velde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

The organic solute transporter  - , Ost -Ost , is essential for intestinal bile acid transport and homeostasis

(2008) A. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unlocking the potential of bile acids in synthesis, supramolecular/materials chemistry and nanoscience

(2007) Nonappa et al.   ORGANIC & BIOMOLECULAR CHEMISTRY