Targeting the gut-liver-immune axis to treat cirrhosis

Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure

(2020) Cornelius Engelmann et al.   JOURNAL OF HEPATOLOGY

Paneth cells promote angiogenesis and regulate portal hypertension in response to microbial signals

(2020) Mohsin Hassan et al.   JOURNAL OF HEPATOLOGY

Intestinal virome in patients with alcoholic hepatitis

(2020) Lu Jiang et al.   HEPATOLOGY

Long-term Outcomes after Fecal Microbiota Transplant in Cirrhosis

(2019) Jasmohan S. Bajaj et al.   GASTROENTEROLOGY

Alcohol, liver disease and the gut microbiota

(2019) Jasmohan S. Bajaj   Nature Reviews Gastroenterology & Hepatology

Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis

(2019) Jessica R. Allegretti et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Fecal Microbial Transplant Capsules are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial

(2019) Jasmohan S Bajaj et al.   HEPATOLOGY

PS-163-Faecal microbiota transplantation with tenofovir is superior to tenofovir alone in improving clinical outcomes in acute-on-chronic liver failure due to hepatitis B: An open label randomized controlled trial (NCT02689245)

(2019) Juned Ahmad et al.   JOURNAL OF HEPATOLOGY

Rifaximin reduces the incidence of spontaneous bacterial peritonitis, variceal bleeding and all-cause admissions in patients on the liver transplant waiting list

(2019) Shayon Salehi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Circulating levels of butyrate are inversely related to portal hypertension, endotoxemia, and systemic inflammation in patients with cirrhosis

(2019) Oriol Juanola et al.   FASEB JOURNAL

FxR-modulates the gut-vascular barrier by regulating the entry sites for bacterial translocation in experimental cirrhosis

(2019) M. Sorribas et al.   JOURNAL OF HEPATOLOGY

Probiotics and prebiotics in intestinal health and disease: from biology to the clinic

(2019) Mary Ellen Sanders et al.   Nature Reviews Gastroenterology & Hepatology

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

(2019) Yi Duan et al.   NATURE

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Circulating microbiome in blood of different circulatory compartments

(2018) Robert Schierwagen et al.   GUT

Restoration of a healthy intestinal microbiota normalizes portal hypertension in a rat model of nonalcoholic steatohepatitis

(2018) Teresa García-Lezana et al.   HEPATOLOGY

Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial

(2018) Paolo Caraceni et al.   LANCET

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy

(2018) Valerio Iebba et al.   Scientific Reports

Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis

(2018) Dragos Ciocan et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Statins: Old drugs as new therapy for liver diseases?

(2018) Elisa Pose et al.   JOURNAL OF HEPATOLOGY

Midodrine and albumin for prevention of complications in patients with cirrhosis awaiting liver transplantation. A randomized placebo-controlled trial

(2018) Elsa Solà et al.   JOURNAL OF HEPATOLOGY

FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid

(2018) Elliot S. Friedman et al.   GASTROENTEROLOGY

Intestinal immune dysregulation driven by dysbiosis promotes barrier disruption and bacterial translocation in rats with cirrhosis

(2018) Leticia Muñoz et al.   HEPATOLOGY

Multidrug-resistant bacterial infections in patients with decompensated cirrhosis and with acute-on-chronic liver failure in Europe

(2018) Javier Fernández et al.   JOURNAL OF HEPATOLOGY

Fecal microbiota transplantation induces hepatitis B virus e-antigen (HBeAg) clearance in patients with positive HBeAg after long-term antiviral therapy

(2017) Yan-Dan Ren et al.   HEPATOLOGY

Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

(2017) Jasmohan S. Bajaj et al.   HEPATOLOGY

Intestinal fungi contribute to development of alcoholic liver disease

(2017) An-Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The gut microbiome and liver cancer: mechanisms and clinical translation

(2017) Le-Xing Yu et al.   Nature Reviews Gastroenterology & Hepatology

Type VI Secretion Effectors: Methodologies and Biology

(2017) Yun-Wei Lien et al.   Frontiers in Cellular and Infection Microbiology

The Intestinal Microbiome in Infectious Diseases: The Clinical Relevance of a Rapidly Emerging Field

(2017) Vanessa C Harris et al.   Open Forum Infectious Diseases

Pathogenesis of Alcoholic Liver Disease

(2016) Winston Dunn et al.   Clinics in Liver Disease

Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis

(2016) Juan G. Abraldes et al.   GASTROENTEROLOGY

MicroRNA-320a Strengthens Intestinal Barrier Function and Follows the Course of Experimental Colitis

(2016) Friederike Cordes et al.   INFLAMMATORY BOWEL DISEASES

Selective intestinal decontamination with norfloxacin enhances a regulatory T cell-mediated inflammatory control mechanism in cirrhosis

(2016) Oriol Juanola et al.   LIVER INTERNATIONAL

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

Secretory IgA in the Coordination of Establishment and Maintenance of the Microbiota

(2016) Oliver Pabst et al.   TRENDS IN IMMUNOLOGY

Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes

(2016) Xiao-Wei Zhang et al.   Oncotarget

Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease

(2015) M Llopis et al.   GUT

Fecal microbiota transplantation in the management of hepatic encephalopathy

(2015) Dina Kao et al.   HEPATOLOGY

Use of Germ-Free Animal Models in Microbiota-Related Research

(2015) Maha Al-Asmakh et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Galacto-oligosaccharides Protect the Intestinal Barrier by Maintaining the Tight Junction Network and Modulating the Inflammatory Responses after a Challenge with the Mycotoxin Deoxynivalenol in Human Caco-2 Cell Monolayers and B6C3F1 Mice

(2015) Peyman Akbari et al.   JOURNAL OF NUTRITION

A gut-vascular barrier controls the systemic dissemination of bacteria

(2015) Ilaria Spadoni et al.   SCIENCE

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance

(2014) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model

(2014) AKITOSHI DOUHARA et al.   Molecular Medicine Reports

Effects of alcohol on intestinal epithelial barrier permeability and expression of tight junction-associated proteins

(2014) YING WANG et al.   Molecular Medicine Reports

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications

(2013) Rita Garcia-Martinez et al.   HEPATOLOGY

Phylogenetic Analysis of Dysbiosis in Ulcerative Colitis During Remission

(2013) Mirjana Rajilić-Stojanović et al.   INFLAMMATORY BOWEL DISEASES

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

(2013) Genta Kakiyama et al.   JOURNAL OF HEPATOLOGY

Altered profile of human gut microbiome is associated with cirrhosis and its complications

(2013) Jasmohan S. Bajaj et al.   JOURNAL OF HEPATOLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Acute-on chronic liver failure

(2012) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis

(2012) Thomas Reiberger et al.   JOURNAL OF HEPATOLOGY

Altered intestinal tight junctions’ expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability

(2011) Stelios F. Assimakopoulos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide

(2011) E. M. Fernandez et al.   GUT

Spontaneous bacterial peritonitis: recent guidelines and beyond

(2011) R Wiest et al.   GUT

Characterization of fecal microbial communities in patients with liver cirrhosis

(2011) Yanfei Chen et al.   HEPATOLOGY

Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense

(2011) Zora Teltschik et al.   HEPATOLOGY

Future treatment of chronic hepatitis C with direct acting antivirals: is resistance important?

(2011) Philippe Halfon et al.   LIVER INTERNATIONAL

Bacterial-Epithelial Contact Is a Key Determinant of Host Innate Immune Responses to Enteropathogenic and Enteroaggregative Escherichia coli

(2011) Lindsey A. Edwards et al.   PLoS One

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

(2010) Sylvie Rabot et al.   FASEB JOURNAL

Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis

(2010) Vasiliki Arvaniti et al.   GASTROENTEROLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Rifaximin Treatment in Hepatic Encephalopathy

(2010) Nathan M. Bass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of TNBS-induced colitis by different Lactobacillus and Bifidobacterium strains is associated with an expansion of γδT and regulatory T cells of intestinal intraepithelial lymphocytes

(2009) Marianna Roselli et al.   INFLAMMATORY BOWEL DISEASES

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

β-Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis

(2009) Marco Senzolo et al.   LIVER INTERNATIONAL

FXR: a metabolic regulator and cell protector

(2008) Yan-Dong Wang et al.   CELL RESEARCH