Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

A dysregulated bile acid-gut microbiota axis contributes to obesity susceptibility

(2020) Meilin Wei et al.   EBioMedicine

Ursodeoxycholic Acid Accelerates Bile Acid Enterohepatic Circulation

(2019) Yunjing Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ursodeoxycholic Acid Alters Bile Acid and Fatty Acid Profiles in a Mouse Model of Diet-Induced Obesity

(2019) Yunjing Zhang et al.   Frontiers in Pharmacology

Adenine nucleotide-mediated regulation of hepatic PTP1B activity in mouse models of type 2 diabetes

(2019) Xiao Yang et al.   DIABETOLOGIA

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes

(2019) Oscar Chávez-Talavera et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Strategy for an Association Study of the Intestinal Microbiome and Brain Metabolome Across the Lifespan of Rats

(2018) Tianlu Chen et al.   ANALYTICAL CHEMISTRY

Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders

(2018) Cynthia Rajani et al.   CLINICAL SCIENCE

Food withdrawal alters the gut microbiota and metabolome in mice

(2018) Xiaojiao Zheng et al.   FASEB JOURNAL

Bile acids in glucose metabolism in health and disease

(2018) Hagit Shapiro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis

(2018) Maheul Ploton et al.   JOURNAL OF HEPATOLOGY

Role of Bile Acids in Metabolic Control

(2018) Antonio Molinaro et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Calorie restriction and its impact on gut microbial composition and global metabolism

(2018) Xiaojiao Zheng et al.   Frontiers of Medicine

The ratio of dihomo-γ-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity

(2017) Sha Lei et al.   FASEB JOURNAL

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

(2017) Anna Worthmann et al.   NATURE MEDICINE

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Animal models for diabetes: Understanding the pathogenesis and finding new treatments

(2016) Aileen King et al.   BIOCHEMICAL PHARMACOLOGY

Influence of Roux-en-Y gastric bypass on plasma bile acid profiles: a comparative study between rats, pigs and humans

(2016) V Spinelli et al.   INTERNATIONAL JOURNAL OF OBESITY

Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

(2015) Stefano Fiorucci et al.   TRENDS IN MOLECULAR MEDICINE

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Loss ofCyp8b1Improves Glucose Homeostasis by Increasing GLP-1

(2014) Achint Kaur et al.   DIABETES

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Very Low Carbohydrate Diet Significantly Alters the Serum Metabolic Profiles in Obese Subjects

(2013) Yunjuan Gu et al.   JOURNAL OF PROTEOME RESEARCH

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

3-Ketocholanoic Acid Is the Major in Vitro Human Hepatic Microsomal Metabolite of Lithocholic Acid

(2009) A. K. Deo et al.   DRUG METABOLISM AND DISPOSITION

Bile acid-activated receptors in the treatment of dyslipidemia and related disorders

(2009) Stefano Fiorucci et al.   PROGRESS IN LIPID RESEARCH

Identification of Human Hepatic Cytochrome P450 Enzymes Involved in the Biotransformation of Cholic and Chenodeoxycholic Acid

(2008) A. K. Deo et al.   DRUG METABOLISM AND DISPOSITION