Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?

Measures of Obesity and Risk of Crohnʼs Disease and Ulcerative Colitis

(2015) Hamed Khalili et al.   INFLAMMATORY BOWEL DISEASES

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid

(2014) J. R. F. Walters et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

(2014) Genta Kakiyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

(2014) Dirk Gevers et al.   Cell Host & Microbe

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis

(2014) Joshua Terc et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease

(2014) Margherita T Cantorna et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cholestyramine Treats Primary Sclerosing Cholangitis-Associated Inflammatory Bowel Disease

(2014) P. Pavlidis et al.   Journal of Crohns & Colitis

A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS

(2014) Genta Kakiyama et al.   JOURNAL OF LIPID RESEARCH

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

(2014) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis

(2014) Xueyan Zhou et al.   Nature Communications

Review article: evidence-based dietary advice for patients with inflammatory bowel disease

(2013) E. Richman et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Intestinal Permeability Defects: Is It Time to Treat?

(2013) Matthew A. Odenwald et al.   Clinical Gastroenterology and Hepatology

Western diet induces dysbiosis with increasedE coliin CEABAC10 mice,alters host barrier function favouring AIEC colonisation

(2013) Margarita Martinez-Medina et al.   GUT

Colonic mucosa-associated diffusely adherentafaC+ Escherichia coliexpressinglpfAandpksare increased in inflammatory bowel disease and colon cancer

(2013) Maelle Prorok-Hamon et al.   GUT

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids

(2013) Rohit Kohli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis

(2013) Weicheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of the fecal bile acid profile by gut microbiota in cirrhosis

(2013) Genta Kakiyama et al.   JOURNAL OF HEPATOLOGY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation

(2013) Barbara Renga et al.   PLoS One

Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery

(2013) Malin Werling et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Shotgun cholanomics of ileal fluid

(2012) Yingjie Chen et al.   BIOCHIMIE

Activation of the bile acid receptor GPBAR1 protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs and aspirin in mice

(2012) Sabrina Cipriani et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors

(2012) Tatiana F.S. Teixeira et al.   CLINICAL NUTRITION

Bile salts induce long polar fimbriae expression favouring Crohn's disease-associated adherent-invasiveEscherichia coliinteraction with Peyer's patches

(2012) Benoit Chassaing et al.   ENVIRONMENTAL MICROBIOLOGY

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohnʼs Disease

(2012) Le-Ning Xue et al.   INFLAMMATORY BOWEL DISEASES

Faecal calprotectin levels before and after weight loss in obese and overweight subjects

(2012) P Kant et al.   INTERNATIONAL JOURNAL OF OBESITY

Circulating Zonulin, a Marker of Intestinal Permeability, Is Increased in Association with Obesity-Associated Insulin Resistance

(2012) José María Moreno-Navarrete et al.   PLoS One

Pharmacological Activation of the Bile Acid Nuclear Farnesoid X Receptor Is Feasible in Patients with Quiescent Crohn's Colitis

(2012) Fiona D. M. van Schaik et al.   PLoS One

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

(2012) Jie Cheng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PSC, AIH and overlap syndrome in inflammatory bowel disease

(2012) P.J. Trivedi et al.   Clinics and Research in Hepatology and Gastroenterology

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

Low levels of bile acids increase bacterial uptake in colonic biopsies from patients with collagenous colitis in remission

(2011) A. Münch et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine

(2011) Raffaella M. Gadaleta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice

(2011) Stefano Fiorucci et al.   BRITISH JOURNAL OF PHARMACOLOGY

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

(2011) Benoit Chassaing et al.   JOURNAL OF CLINICAL INVESTIGATION

NSAIDs: take with food or after fasting?

(2011) Kim D. Rainsford et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The impact of inflammatory bowel disease post-liver transplantation for primary sclerosing cholangitis

(2011) Deepak Joshi et al.   LIVER INTERNATIONAL

Characterization of Bacteria in Biopsies of Colon and Stools by High Throughput Sequencing of the V2 Region of Bacterial 16S rRNA Gene in Human

(2011) Yukihide Momozawa et al.   PLoS One

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs

(2010) Yong Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease

(2010) Jürgen Glas et al.   INFLAMMATORY BOWEL DISEASES

Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease 12

(2010) Millie D. Long et al.   INFLAMMATORY BOWEL DISEASES

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

(2010) Daniel N. Frank et al.   INFLAMMATORY BOWEL DISEASES

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Postprandial plasma bile acid responses in normal weight and obese subjects

(2010) C. Glicksman et al.   ANNALS OF CLINICAL BIOCHEMISTRY

A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

(2009) Julian R.F. Walters et al.   Clinical Gastroenterology and Hepatology

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

(2009) Koji Hase et al.   NATURE

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease

(2009) Janet Jansson et al.   PLoS One

Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease

(2009) Carsten Gnewuch et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation

(2008) Francesco Raimondi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions

(2008) Verónica-Haydée Lugo-Martínez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Medical management of patients with ileal pouch anal anastomosis after restorative procto-colectomy

(2008) Matthew W. Johnson et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Bile acids: Trying to understand their chemistry and biology with the hope of helping patients

(2008) Alan F. Hofmann   HEPATOLOGY

Lactobacillus casei downregulates commensalsʼ inflammatory signals in Crohnʼs disease mucosa

(2008) Marta Llopis et al.   INFLAMMATORY BOWEL DISEASES

Chenodeoxycholate Is an Inhibitor ofClostridium difficileSpore Germination

(2008) Joseph A. Sorg et al.   JOURNAL OF BACTERIOLOGY

Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores

(2008) J. A. Sorg et al.   JOURNAL OF BACTERIOLOGY

Failure of T cell homing, reduced CD4/CD8   intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice

(2008) S. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier

(2007) Juan Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY