Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression

Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback

(2019) Denis Menshykau et al.   Nature Communications

Liquid-crystal organization of liver tissue

(2019) Hernán Morales-Navarrete et al.   eLife

Hydrodynamics of bile flow: Lessons from computational modeling

(2018) Peter L.M. Jansen   HEPATOLOGY

Zooming in on liver zonation

(2018) Daniel J. Felmlee et al.   HEPATOLOGY

Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis

(2018) Anika L. Dzierlenga et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control

(2018) Mario Brosch et al.   Nature Communications

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

The ascending pathophysiology of cholestatic liver disease

(2017) Peter L.M. Jansen et al.   HEPATOLOGY

Microcirculation in the murine liver: a computational fluid dynamic model based on 3D reconstruction from in vivo microscopy

(2017) Monica Piergiovanni et al.   JOURNAL OF BIOMECHANICS

Diagnostic considerations for cholestatic liver disease

(2017) Galia Pollock et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Pathology of non-alcoholic fatty liver disease

(2017) Pierre Bedossa   LIVER INTERNATIONAL

The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2017) Monica D. Chow et al.   MOLECULAR ASPECTS OF MEDICINE

Hepatocyte polyploidization and its association with pathophysiological processes

(2017) Min-Jun Wang et al.   Cell Death & Disease

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule

(2017) Kirstin Meyer et al.   Cell Systems

Transaminase abnormalities and adaptations of the liver lobule manifest at specific cut-offs of steatosis

(2017) Andrew Hall et al.   Scientific Reports

Chemical Principles in Tissue Clearing and Staining Protocols for Whole-Body Cell Profiling

(2016) Kazuki Tainaka et al.   Annual Review of Cell and Developmental Biology

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Clarifying Tissue Clearing

(2015) Douglas S. Richardson et al.   CELL

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

(2015) Brian C. Ferslew et al.   DIGESTIVE DISEASES AND SCIENCES

A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

(2015) Hernán Morales-Navarrete et al.   eLife

Morpheus: a user-friendly modeling environment for multiscale and multicellular systems biology

(2014) Jörn Starruß et al.   BIOINFORMATICS

Raman spectroscopy analysis of lipid droplets content, distribution and saturation level in Non-Alcoholic Fatty Liver Disease in mice

(2014) Kamila Kochan et al.   Journal of Biophotonics

Predictive Models Based on Support Vector Machines: Whole-Brain versus Regional Analysis of Structural MRI in the Alzheimer's Disease

(2014) Alessandra Retico et al.   JOURNAL OF NEUROIMAGING

Digital pathology and image analysis in tissue biomarker research

(2014) Peter W. Hamilton et al.   METHODS

Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2014) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Differential Intrahepatic Phospholipid Zonation in Simple Steatosis and Nonalcoholic Steatohepatitis

(2013) Julia Wattacheril et al.   PLoS One

A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability for homogeneous perfusion

(2012) Charlotte Debbaut et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Perfusion Characteristics of the Human Hepatic Microcirculation Based on Three-Dimensional Reconstructions and Computational Fluid Dynamic Analysis

(2012) Charlotte Debbaut et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Vacuolation in hepatocyte nuclei is a marker of senescence

(2012) Aloysious Aravinthan et al.   JOURNAL OF CLINICAL PATHOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Biopsy and personalized medicine

(2012) Hayet Amalou et al.   Nature Reviews Gastroenterology & Hepatology

Variations in ATP-Binding Cassette Transporter Regulation during the Progression of Human Nonalcoholic Fatty Liver Disease

(2011) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

BoneJ: Free and extensible bone image analysis in ImageJ

(2010) Michael Doube et al.   BONE

Physiological hepatic nuclear vacuolation-how long does it persist?

(2010) Adam P Levene et al.   HISTOPATHOLOGY

Globally optimal stitching of tiled 3D microscopic image acquisitions

(2009) S. Preibisch et al.   BIOINFORMATICS

Bile acid levels are increased in the liver of patients with steatohepatitis

(2009) Márcia M. Aranha et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Electron microscopic findings in non-alcoholic fatty liver disease: Is there a difference between hepatosteatosis and steatohepatitis?

(2009) Emel Ahishali et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

(2008) Naga Chalasani et al.   JOURNAL OF HEPATOLOGY