Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage

Inhibition of stearoyl-CoA desaturase 1 potentiates anti-tumor activity of amodiaquine in non-small cell lung cancer

(2022) Xiaolei Hu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Metabolic regulation of ferroptosis in the tumor microenvironment

(2022) Nneka E. Mbah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion

(2022) Sophiya Siddiqui et al.   Cancers

The Antianginal Drug Perhexiline Displays Cytotoxicity against Colorectal Cancer Cells In Vitro: A Potential for Drug Repurposing

(2022) Bimala Dhakal et al.   Cancers

ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective

(2022) Carlotta Granchi   EXPERT OPINION ON THERAPEUTIC PATENTS

P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis

(2022) Yahui Zhu et al.   HEPATOLOGY

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

(2022) Mario Löhr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion

(2022) Nian Jiang et al.   Nature Communications

Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States—Current View of Knowledge

(2022) Katarzyna Lipke et al.   Cells

An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

(2022) Jin Zhou et al.   MOLECULAR CELL

Acetyl-CoA Synthetase 2 as a Therapeutic Target in Tumor Metabolism

(2022) Mengfang Liu et al.   Cancers

Frontiers in the treatment of glioblastoma: Past, present and emerging

(2021) Taskeen Iqbal Janjua et al.   ADVANCED DRUG DELIVERY REVIEWS

Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes

(2021) Montserrat A. de la Rosa Rodriguez et al.   Molecular Metabolism

Up-regulation of DGAT1 in cancer tissues and tumor-infiltrating macrophages influenced survival of patients with gastric cancer

(2021) Ping He et al.   BMC CANCER

Inhibition of Stearoyl-CoA Desaturase Induces the Unfolded Protein Response in Pancreatic Tumors and Suppresses Their Growth

(2021) Kaitlin Skrypek et al.   PANCREAS

Lipid Droplet Contact Sites in Health and Disease

(2021) Eva Herker et al.   TRENDS IN CELL BIOLOGY

Lipid metabolism in cancer: New perspectives and emerging mechanisms

(2021) Lindsay A. Broadfield et al.   DEVELOPMENTAL CELL

Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells

(2021) Alejandro Morales et al.   LABORATORY INVESTIGATION

Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer

(2021) Yuan Liu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

DGAT1 Expression Promotes Ovarian Cancer Progression and Is Associated with Poor Prognosis

(2021) Leilei Xia et al.   Journal of Immunology Research

A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials

(2021) Elisabete Cruz Da Silva et al.   Cancers

Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma

(2021) Yulong Chen et al.   BMC CANCER

LPCAT1 overexpression promotes the progression of hepatocellular carcinoma

(2021) Rong-Quan He et al.   Cancer Cell International

Mammalian lipids: structure, synthesis and function

(2021) Shamshad Cockcroft   Essays in Biochemistry

Lipid Droplet Biosynthesis Impairment through DGAT2 Inhibition Sensitizes MCF7 Breast Cancer Cells to Radiation

(2021) Clelia Nisticò et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SOAT1 is a new prognostic factor of colorectal cancer

(2021) Xin-Chun Wang et al.   IRISH JOURNAL OF MEDICAL SCIENCE

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

(2021) Haejin Yoon et al.   MOLECULAR CELL

Simultaneous silencing of lysophosphatidylcholine acyltransferases 1-4 by nucleic acid nanoparticles (NANPs) improves radiation response of melanoma cells

(2021) Renata F Saito et al.   Nanomedicine-Nanotechnology Biology and Medicine

Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance

(2021) Wei Wu et al.   PHARMACOLOGICAL RESEARCH

High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer

(2021) Carolin Eckhardt et al.   PROSTATE CANCER AND PROSTATIC DISEASES

SREBP1 site 1 protease inhibitor PF-429242 suppresses renal cell carcinoma cell growth

(2021) Tong-bing Wang et al.   Cell Death & Disease

LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma

(2021) Mingyue Tao et al.   Cell Death & Disease

Lipid droplets and ferritin heavy chain: a devilish liaison in human cancer cell radioresistance

(2021) Luca Tirinato et al.   eLife

Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era

(2021) Qimin Hai et al.   Metabolites

Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis

(2021) Meiling Ren et al.   Cell Death Discovery

SOAT1 enhances lung cancer invasiveness by stimulating AKT-mediated mitochondrial fragmentation

(2021) Yijun Mo et al.   Biochemistry and Cell Biology

A new perspective on NAFLD: Focusing on lipid droplets

(2021) Eleonora Scorletti et al.   JOURNAL OF HEPATOLOGY

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2014–2018

(2021) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Amide-Substituted Condensed Pyridine Derivatives as ACSS2 Inhibitors for Treating Cancer

(2021) Ram W. Sabnis   ACS Medicinal Chemistry Letters

Novel Substituted Tetrazoles as ACSS2 Inhibitors for Treating Cancer

(2021) Ram W. Sabnis   ACS Medicinal Chemistry Letters

Lipid Metabolism Influence on Neurodegenerative Disease Progression: Is the Vehicle as Important as the Cargo?

(2021) Raja Elizabeth Estes et al.   Frontiers in Molecular Neuroscience

SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis

(2021) Tingting Zhu et al.   Frontiers in Pharmacology

Lipid Droplets, the Central Hub Integrating Cell Metabolism and the Immune System

(2021) Wei Zhang et al.   Frontiers in Physiology

Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in mice

(2021) Yahui Zhu et al.   JCI Insight

Lipid Droplets, Phospholipase A2, Arachidonic Acid, and Atherosclerosis

(2021) Miguel A. Bermúdez et al.   Biomedicines

Fatostatin inhibits the development of endometrial carcinoma in endometrial carcinoma cells and a xenograft model by targeting lipid metabolism

(2020) Lan Yao et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

(2020) Isabel R Schlaepfer et al.   ENDOCRINOLOGY

A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma

(2020) David C. Smith et al.   INVESTIGATIONAL NEW DRUGS

Lipid droplets: platforms with multiple functions in cancer hallmarks

(2020) André L. S. Cruz et al.   Cell Death & Disease

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

(2020) Cyril Corbet et al.   Nature Communications

Glioblastoma multiforme: novel therapeutic targets

(2020) Matthew Muir et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

New kid on the block: lipid droplets in the nucleus

(2020) Antonio D. Barbosa et al.   FEBS Journal

Perhexiline demonstrates FYN-mediated anti-tumor activity in glioblastoma

(2020) Shiva Kant et al.   MOLECULAR CANCER THERAPEUTICS

Structure and mechanism of human diacylglycerol O-acyltransferase 1

(2020) Lie Wang et al.   NATURE

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

(2020) Xuewu Sui et al.   NATURE

Structural basis for catalysis and substrate specificity of human ACAT1

(2020) Hongwu Qian et al.   NATURE

Structure of nevanimibe-bound tetrameric human ACAT1

(2020) Tao Long et al.   NATURE

Lipid droplets throughout the evolutionary tree

(2020) Peter K. Lundquist et al.   PROGRESS IN LIPID RESEARCH

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

(2020) Chengcheng Guan et al.   Nature Communications

Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress

(2020) Xiang Cheng et al.   Cell Metabolism

CHOLESTEROL REVIEW: A METABOLICALLY IMPORTANT MOLECULE

(2020) David S. Schade et al.   Endocrine Practice

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

(2020) Tobiloba E. Oni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein Quality Control and Lipid Droplet Metabolism

(2020) Melissa A. Roberts et al.   Annual Review of Cell and Developmental Biology

The “discovery” of lipid droplets: A brief history of organelles hidden in plain sight

(2020) Rosalind A. Coleman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulation of lipid droplet homeostasis by hypoxia inducible lipid droplet associated HILPDA

(2020) Montserrat A. de la Rosa Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Droplets Maintain Energy Homeostasis and Glioblastoma Growth via Autophagic Release of Stored Fatty Acids

(2020) Xiaoning Wu et al.   iScience

Leading the way in the nervous system: Lipid Droplets as new players in health and disease

(2020) Vitor Teixeira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid metabolism and cancer

(2020) Xueli Bian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A metastasis map of human cancer cell lines

(2020) Xin Jin et al.   NATURE

Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases

(2020) Sabina Cisa-Wieczorek et al.   Cells

Extracellular Fatty Acids are the Major Contributor to Lipid Synthesis in Prostate Cancer

(2019) Seher Balaban et al.   MOLECULAR CANCER RESEARCH

Astrocytoma progression scoring system based on the WHO 2016 criteria

(2019) Zhen-Hang Li et al.   Scientific Reports

Mechanisms of Ferroptosis and Relations With Regulated Cell Death: A Review

(2019) Pengxu Lei et al.   Frontiers in Physiology

DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130

(2019) Francesca Nardi et al.   Scientific Reports

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

(2019) Kamil Sołtysik et al.   Nature Communications

What is ‘LDL cholesterol’?

(2019) Michael V. Holmes et al.   Nature Reviews Cardiology

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals

(2019) Kelin She et al.   Cancer Cell International

Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition–resistant triple-negative breast cancer cells

(2019) Larissa Menezes dos Reis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of TH17 cells

(2019) Hongxing Shen et al.   MOLECULAR IMMUNOLOGY

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

(2019) Junfeng Bi et al.   Cell Metabolism

Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer

(2019) Patrick Lebok et al.   Aging-US

SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity

(2019) Fan Yin et al.   Cell Death & Disease

Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

(2019) Weihua Zhou et al.   Cancers

Lipid droplet‐dependent fatty acid metabolism controls the immune suppressive phenotype of tumor‐associated macrophages

(2019) Hao Wu et al.   EMBO Molecular Medicine

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid Droplets Define a Sub-Population of Breast Cancer Stem Cells

(2019) Benjamin J. Hershey et al.   Journal of Clinical Medicine

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

An Asymmetry in Monolayer Tension Regulates Lipid Droplet Budding Direction

(2018) Aymeric Chorlay et al.   BIOPHYSICAL JOURNAL

The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets

(2018) Anete Romanauska et al.   CELL

SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy

(2018) Xiang Cheng et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

Intestinal Failure and Aberrant Lipid Metabolism in Patients With DGAT1 Deficiency

(2018) Jorik M. van Rijn et al.   GASTROENTEROLOGY

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer

(2018) Yang-An Wen et al.   Cell Death & Disease

The carnitine system and cancer metabolic plasticity

(2018) Mariarosa Anna Beatrice Melone et al.   Cell Death & Disease

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

(2018) Nadav Shai et al.   Nature Communications

Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells

(2018) Barbara Lettiero et al.   Scientific Reports

The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

(2018) Julian Hlouschek et al.   Frontiers in Oncology

Role of DGAT enzymes in triacylglycerol metabolism

(2018) Bhumika Bhatt-Wessel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer

(2018) Viktor Brovkovych et al.   Oncogenesis

Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes

(2018) Gabriela Galicia-Vázquez et al.   Frontiers in Oncology

Phospholipid Remodeling in Physiology and Disease

(2018) Bo Wang et al.   Annual Review of Physiology

SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis

(2018) Zhiwei Jie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

(2018) Maria Elena Pisanu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program

(2018) Anna Maria Giudetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma

(2017) Yiqing Du et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas

(2017) Michael Weller et al.   LANCET ONCOLOGY

Lipid Droplets in Health and Disease

(2017) Gizem Onal et al.   Lipids in Health and Disease

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

(2017) Filippo Veglia et al.   Nature Communications

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

(2017) Thomas W. Flaig et al.   Oncotarget

Epidermal growth factor receptor mediated proliferation depends on increased lipid droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6

(2016) Harrison Penrose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The physics of lipid droplet nucleation, growth and budding

(2016) Abdou Rachid Thiam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

(2016) F. Geng et al.   CLINICAL CANCER RESEARCH

Congenital protein losing enteropathy: an inborn error of lipid metabolism due to DGAT1 mutations

(2016) Joshi Stephen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

PML isoform II plays a critical role in nuclear lipid droplet formation

(2016) Yuki Ohsaki et al.   JOURNAL OF CELL BIOLOGY

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

(2016) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

(2016) Jean-Pierre Etchegaray et al.   MOLECULAR CELL

The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila

(2016) Shree Ram Singh et al.   NATURE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma

(2016) Xing-gang Mao et al.   Oncotarget

Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells

(2016) Jiajin Li et al.   Oncotarget

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

(2016) Peng Ru et al.   Cell Reports

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Analysis of SCAP N-glycosylation and Trafficking in Human Cells

(2016) Chunming Cheng et al.   Jove-Journal of Visualized Experiments

Morphologically and Functionally Distinct Lipid Droplet Subpopulations

(2016) Shuyan Zhang et al.   Scientific Reports

Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer

(2015) Takashi Uehara et al.   ANNALS OF SURGICAL ONCOLOGY

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

Sugar Makes Fat by Talking to SCAP

(2015) Wei Shao et al.   CANCER CELL

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

(2015) Chunming Cheng et al.   CANCER CELL

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

Leptin activation of mTOR pathway in intestinal epithelial cell triggers lipid droplet formation, cytokine production and increased cell proliferation

(2015) Narayana PB Fazolini et al.   CELL CYCLE

Cholesterol trafficking and distribution

(2015) David B. Iaea et al.   Essays in Biochemistry

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease

(2015) Yohei Shibuya et al.   Future Medicinal Chemistry

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

K604, a specific acyl-CoA:cholesterol acyltransferase 1 inhibitor, suppresses proliferation of U251-MG glioblastoma cells

(2015) TAKUJI OHMOTO et al.   Molecular Medicine Reports

Clinical benefit from resection of recurrent glioblastomas: results of a multicenter study including 503 patients with recurrent glioblastomas undergoing surgical resection

(2015) Florian Ringel et al.   NEURO-ONCOLOGY

PD-L1 expression and prognostic impact in glioblastoma

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR

(2015) Sue Ellen Verbrugge et al.   Oncotarget

Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

(2015) Deliang Guo et al.   CURRENT PHARMACEUTICAL DESIGN

FTIR spectroscopy reveals lipid droplets in drug resistant laryngeal carcinoma cells through detection of increased ester vibrational bands intensity

(2014) Sanjica Rak et al.   ANALYST

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth

(2014) Lizhen Wu et al.   DEVELOPMENTAL CELL

Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics

(2014) William A. Prinz   JOURNAL OF CELL BIOLOGY

Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis

(2014) Susanne Grube et al.   JOURNAL OF NEURO-ONCOLOGY

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

(2014) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

(2014) Anna Sophie Berghoff et al.   NEURO-ONCOLOGY

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity

(2013) K. J. Williams et al.   CANCER RESEARCH

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Stearoyl-CoA Desaturase 1 Is a Novel Molecular Therapeutic Target for Clear Cell Renal Cell Carcinoma

(2013) C. A. von Roemeling et al.   CLINICAL CANCER RESEARCH

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

FOXO3 Growth Inhibition of Colonic Cells Is Dependent on Intraepithelial Lipid Droplet Density

(2013) Wentao Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Accumulation of Lipid Droplets in Hepatocyte Nuclei of PFOA-exposed BALB/c Mice

(2013) Ling Wang et al.   Scientific Reports

Nuclear lipid droplets: A novel nuclear domain

(2012) J.P. Layerenza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A clinical review of treatment outcomes in glioblastoma multiforme—the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival?

(2012) K Rock et al.   BRITISH JOURNAL OF RADIOLOGY

The Definition of Primary and Secondary Glioblastoma

(2012) H. Ohgaki et al.   CLINICAL CANCER RESEARCH

Controlling the size of lipid droplets: lipid and protein factors

(2012) Hongyuan Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets

(2012) Kai Hsieh et al.   JOURNAL OF CELL SCIENCE

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2

(2012) Jenson Qi et al.   JOURNAL OF LIPID RESEARCH

Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel

(2012) Isabel R. Schlaepfer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Translation Inhibitors Induce Formation of Cholesterol Ester-Rich Lipid Droplets

(2012) Michitaka Suzuki et al.   PLoS One

Glioblastoma: From Molecular Pathology to Targeted Treatment

(2011) Timothy F. Cloughesy et al.   Annual Review of Pathology-Mechanisms of Disease

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

(2011) Renata M. Oballa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

(2011) D. A. Gross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

(2011) Robert L. Dow et al.   ACS Medicinal Chemistry Letters

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

Lipid droplets: size matters

(2011) M. Suzuki et al.   Microscopy

Liver X Receptor Signaling Pathways and Atherosclerosis

(2010) Anna C. Calkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas

(2010) Deliang Guo et al.   CELL CYCLE

Cholesterol, the central lipid of mammalian cells

(2010) Frederick R Maxfield et al.   CURRENT OPINION IN CELL BIOLOGY

Acyl-coenzyme A:cholesterol acyltransferases

(2009) Ta-Yuan Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases

(2009) Gema Pérez-Chacón et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

(2009) D. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Quantitative Label-Free Imaging of Lipid Composition and Packing of Individual Cellular Lipid Droplets Using Multiplex CARS Microscopy

(2008) Hilde A. Rinia et al.   BIOPHYSICAL JOURNAL

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane lipids: where they are and how they behave

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