Lipid Droplet Contact Sites in Health and Disease

NAFLD 2020: The State of the Disease

(2020) Thomas G. Cotter et al.   GASTROENTEROLOGY

Rab7 controls lipid droplet-phagosome association during mycobacterial infection

(2020) Natalia R. Roque et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Tether Me, Tether Me Not—Dynamic Organelle Contact Sites in Metabolic Rewiring

(2020) Maria Bohnert   DEVELOPMENTAL CELL

The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly

(2020) Gabrielle Vieyres et al.   PLoS Pathogens

Lipophagy Impairment Is Associated With Disease Progression in NAFLD

(2020) Simone Carotti et al.   Frontiers in Physiology

XK is a partner for VPS13A: a molecular link between Chorea-Acanthocytosis and McLeod Syndrome

(2020) Jae-Sook Park et al.   MOLECULAR BIOLOGY OF THE CELL

Direct lysosome-based autophagy of lipid droplets in hepatocytes

(2020) Ryan J. Schulze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promethin Is a Conserved Seipin Partner Protein

(2019) Inês G. Castro et al.   Cells

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

(2019) Kamil Sołtysik et al.   Nature Communications

Cerebellar ataxia disease–associated Snx14 promotes lipid droplet growth at ER–droplet contacts

(2019) Sanchari Datta et al.   JOURNAL OF CELL BIOLOGY

Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis

(2019) Hanaa Hariri et al.   JOURNAL OF CELL BIOLOGY

The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation

(2019) Dongfang Li et al.   Cell Reports

Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

(2019) Wondwossen M Yeshaw et al.   eLife

Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication

(2019) Orly Laufman et al.   CELL

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

(2019) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy

(2019) Charlotte E. Melia et al.   mBio

The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis

(2019) Arnaud Sans et al.   Scientific Reports

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment

(2019) Ji-Young Lee et al.   Cell Reports

Hepatic Fatty Acid Balance and Hepatic Fat Content in Severely Obese Humans

(2019) Kelli A Lytle et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mitochondrial lipid droplet formation as a detoxification mechanism to sequester and degrade excessive urothelial membranes

(2019) Yi Liao et al.   MOLECULAR BIOLOGY OF THE CELL

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Come a little bit closer! Lipid droplet-ER contact sites are getting crowded

(2019) Marie Hugenroth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

(2019) Jeeyun Chung et al.   DEVELOPMENTAL CELL

Recessive mutations in >VPS13D cause childhood onset movement disorders

(2018) Julie Gauthier et al.   ANNALS OF NEUROLOGY

Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects

(2018) Eunju Seong et al.   ANNALS OF NEUROLOGY

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production

(2018) Jingshu Zhang et al.   Cell Host & Microbe

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

SNX14 mutations affect endoplasmic reticulum-associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20

(2018) Dale Bryant et al.   HUMAN MOLECULAR GENETICS

Rab18 promotes lipid droplet (LD) growth by tethering the ER to LDs through SNARE and NRZ interactions

(2018) Dijin Xu et al.   JOURNAL OF CELL BIOLOGY

Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

(2018) Nadav Shai et al.   Nature Communications

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

(2018) Matthew Knight et al.   PLoS Pathogens

VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites

(2018) Nikit Kumar et al.   JOURNAL OF CELL BIOLOGY

Phospholipid synthesis fueled by lipid droplets drives the structural development of poliovirus replication organelles

(2018) Ekaterina G. Viktorova et al.   PLoS Pathogens

Human SEIPIN Binds Anionic Phospholipids

(2018) Renhong Yan et al.   DEVELOPMENTAL CELL

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis

(2018) Natalie Krahmer et al.   DEVELOPMENTAL CELL

Cryo–electron microscopy structure of the lipid droplet–formation protein seipin

(2018) Xuewu Sui et al.   JOURNAL OF CELL BIOLOGY

Perilipin-2 is critical for efficient lipoprotein and hepatitis C virus particle production

(2018) Susan Lassen et al.   JOURNAL OF CELL SCIENCE

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Applying systems-level spectral imaging and analysis to reveal the organelle interactome

(2017) Alex M. Valm et al.   NATURE

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

(2017) Sabrina J. Nolan et al.   PLoS Pathogens

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Tether Is a Tether Is a Tether: Tethering at Membrane Contact Sites

(2016) Michal Eisenberg-Bord et al.   DEVELOPMENTAL CELL

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes

(2016) Wenyi Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

(2016) Martin Pagac et al.   Cell Reports

Building Viral Replication Organelles: Close Encounters of the Membrane Types

(2016) Peter D. Nagy et al.   PLoS Pathogens

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites

(2015) Alexandra Grippa et al.   JOURNAL OF CELL BIOLOGY

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Mutations in SNX14 Cause a Distinctive Autosomal-Recessive Cerebellar Ataxia and Intellectual Disability Syndrome

(2014) Anna C. Thomas et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication

(2014) W.-C. Tang et al.   JOURNAL OF VIROLOGY

Rab18 is required for viral assembly of hepatitis C virus through trafficking of the core protein to lipid droplets

(2014) Hiromichi Dansako et al.   VIROLOGY

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Perilipin discerns chronic from acute hepatocellular steatosis

(2013) Lena Maria Pawella et al.   JOURNAL OF HEPATOLOGY

A new seipin-associated neurodegenerative syndrome

(2013) Encarna Guillén-Navarro et al.   JOURNAL OF MEDICAL GENETICS

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid Droplet-Binding Protein TIP47 Regulates Hepatitis C Virus RNA Replication through Interaction with the Viral NS5A Protein

(2013) Dorothee A. Vogt et al.   PLoS Pathogens

Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

(2013) Shadi Salloum et al.   PLoS Pathogens

Lipid Droplets Control the Maternal Histone Supply of Drosophila Embryos

(2012) Zhihuan Li et al.   CURRENT BIOLOGY

Fsp27/CIDECis a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate

(2012) Anna Vilà-Brau et al.   JOURNAL OF LIPID RESEARCH

A novel role for lipid droplets in the organismal antibacterial response

(2012) Preetha Anand et al.   eLife

Loss-of-Function Mutations in RAB18 Cause Warburg Micro Syndrome

(2011) Danai Bem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

(2011) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance

(2011) Sung Hee Choi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

(2009) Perry E. Bickel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Leading a Sheltered Life: Intracellular Pathogens and Maintenance of Vacuolar Compartments

(2009) Yadunanda Kumar et al.   Cell Host & Microbe

Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B

(2009) Jing Ye et al.   Cell Metabolism

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic  -helix

(2009) E. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

(2009) Marcelo M. Samsa et al.   PLoS Pathogens

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

(2008) Kaori Minehira et al.   JOURNAL OF LIPID RESEARCH

Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole

(2008) J. L. Cocchiaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens