The carnitine system and cancer metabolic plasticity

Metabolic interactions with cancer epigenetics

(2017) Xia Gao et al.   MOLECULAR ASPECTS OF MEDICINE

Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences

(2017) A Valentino et al.   ONCOGENE

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation

(2016) Cyril Corbet et al.   Cell Metabolism

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Post-translational modification by acetylation regulates the mitochondrial carnitine/acylcarnitine transport protein

(2016) Nicola Giangregorio et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

(2016) Natalie J. German et al.   MOLECULAR CELL

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

(2016) Robert U Svensson et al.   NATURE MEDICINE

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

(2016) P-P Liu et al.   ONCOGENE

Carnitine palmitoyltransferase 1C: From cognition to cancer

(2016) Núria Casals et al.   PROGRESS IN LIPID RESEARCH

Metabolic Pathway Signatures Associated with Urinary Metabolite Biomarkers Differentiate Bladder Cancer Patients from Healthy Controls

(2016) Won Tae Kim et al.   YONSEI MEDICAL JOURNAL

Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer

(2016) Sabina Pucci et al.   Oncotarget

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

(2016) Eoin McDonnell et al.   Cell Reports

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing

(2015) Yong Wu et al.   BREAST CANCER RESEARCH AND TREATMENT

Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise

(2015) Sarah E. Seiler et al.   Cell Metabolism

Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability

(2015) Francesca Patella et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[18F]Fluoro-d-Glucose Uptake in Prostate Cancer Mouse Xenografts

(2015) Isabel R. Schlaepfer et al.   MOLECULAR IMAGING AND BIOLOGY

Erratum: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

SRC: A Century of Science Brought to the Clinic

(2015) Alexey Aleshin et al.   NEOPLASIA

MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA synthetase long-chain family member 1 (ACSL1) mRNA

(2014) Ming Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism

(2014) Alessandra Cirillo et al.   CANCER BIOLOGY & THERAPY

Oncogene Pathway Activation in Mammary Tumors Dictates FDG-PET Uptake

(2014) J. V. Alvarez et al.   CANCER RESEARCH

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

(2014) Deborah M. Muoio   CELL

Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth

(2014) M. Ríos et al.   EUROPEAN JOURNAL OF CANCER

Obesity and lipid stress inhibit carnitine acetyltransferase activity

(2014) Sarah E. Seiler et al.   JOURNAL OF LIPID RESEARCH

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer

(2014) Michael L Gatza et al.   NATURE GENETICS

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas

(2014) Tomihiro Wakamiya et al.   NEUROPATHOLOGY

High Metastaticgastric and Breast Cancer Cells Consume Oleic Acid in an AMPK Dependent Manner

(2014) Shuai Li et al.   PLoS One

Regulation of mitochondrial fatty acid β-oxidation in human: What can we learn from inborn fatty acid β-oxidation deficiencies?

(2013) Jean Bastin   BIOCHIMIE

PPAR  and fatty acid oxidation mediate glucocorticoid resistance in chronic lymphocytic leukemia

(2013) S. Tung et al.   BLOOD

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

(2013) N Sanchez-Macedo et al.   CELL DEATH AND DIFFERENTIATION

Carnitine-Acyltransferase System Inhibition, Cancer Cell Death, and Prevention of Myc-Induced Lymphomagenesis

(2013) Annalisa Pacilli et al.   JNCI-Journal of the National Cancer Institute

MicroRNA-27a Regulates Lipid Metabolism and Inhibits Hepatitis C Virus Replication in Human Hepatoma Cells

(2013) T. Shirasaki et al.   JOURNAL OF VIROLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel

(2013) Jiajin Li et al.   PLoS One

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Molecular Pathways: Tumor Cells Co-opt the Brain-Specific Metabolism Gene CPT1C to Promote Survival

(2012) P. T. Reilly et al.   CLINICAL CANCER RESEARCH

Ceramide Levels Regulated by Carnitine Palmitoyltransferase 1C Control Dendritic Spine Maturation and Cognition

(2012) Patricia Carrasco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs in metabolism and metabolic disorders

(2012) Veerle Rottiers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378

(2012) M. Carrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells

(2011) Katja Linher-Melville et al.   BMC CANCER

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Chain length-specific properties of ceramides

(2011) Sabine Grösch et al.   PROGRESS IN LIPID RESEARCH

miR-378 ∗ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway

(2010) Lillian J. Eichner et al.   Cell Metabolism

MicroRNAs in lipid metabolism

(2010) Carlos Fernández-Hernando et al.   CURRENT OPINION IN LIPIDOLOGY

Mitochondrial acetylcarnitine provides acetyl groups for nuclear histone acetylation

(2010) Padma Madiraju et al.   Epigenetics

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

MicroRNA-370 controls the expression of MicroRNA-122 and Cpt1α and affects lipid metabolism

(2010) Dimitrios Iliopoulos et al.   JOURNAL OF LIPID RESEARCH

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

(2010) S. H. Najafi-Shoushtari et al.   SCIENCE

MiR-33 Contributes to the Regulation of Cholesterol Homeostasis

(2010) K. J. Rayner et al.   SCIENCE

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice

(2009) Noriko Nakanishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control

(2009) Robert C. Noland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

LNA-mediated microRNA silencing in non-human primates

(2008) Joacim Elmén et al.   NATURE