Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
Authors
Keywords
-
Journal
Cancers
Volume 11, Issue 9, Pages 1231
Publisher
MDPI AG
Online
2019-08-26
DOI
10.3390/cancers11091231
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells
- (2019) Gal Mazor et al. Cell Death & Disease
- IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response
- (2019) Felipe J. Núñez et al. Science Translational Medicine
- Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
- (2019) Timothy F. Cloughesy et al. NATURE MEDICINE
- Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial
- (2019) Patrick Y. Wen et al. JOURNAL OF CLINICAL ONCOLOGY
- Current State of Immunotherapy for Treatment of Glioblastoma
- (2019) Tresa McGranahan et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications
- (2019) Matthieu Gobin et al. CANCER RESEARCH
- A TITE-CRM phase I/II study of disulfiram and copper with concurrent radiation therapy and temozolomide for newly diagnosed glioblastoma.
- (2019) Jiayi Huang et al. JOURNAL OF CLINICAL ONCOLOGY
- Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
- (2019) Weina Zhang et al. CELL
- Dietary methionine influences therapy in mouse cancer models and alters human metabolism
- (2019) Xia Gao et al. NATURE
- The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
- (2018) Milica Momcilovic et al. CANCER CELL
- Gemcitabine and glioblastoma: challenges and current perspectives
- (2018) Chiara Bastiancich et al. DRUG DISCOVERY TODAY
- PBX3/MEK/ERK1/2/LIN28/let-7b positive feedback loop enhances mesenchymal phenotype to promote glioblastoma migration and invasion
- (2018) Xiupeng Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
- (2018) Yajuan Zhang et al. MOLECULAR CELL
- WHO 2016 Classification of gliomas
- (2018) P. Wesseling et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells
- (2018) Sarmistha Talukdar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutant IDH1 Promotes Glioma Formation In Vivo
- (2018) Beatrice Philip et al. Cell Reports
- Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
- (2018) Samuel K. McBrayer et al. CELL
- Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration
- (2018) Estelle Willems et al. ONCOGENE
- Infiltrative and drug‐resistant slow‐cycling cells support metabolic heterogeneity in glioblastoma
- (2018) Lan B Hoang‐Minh et al. EMBO JOURNAL
- Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate
- (2018) Joseph P. Dexter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency
- (2017) Diego Avellaneda Matteo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The current evidence of statin use affecting glioblastoma prognosis
- (2017) Victor M. Lu et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis
- (2017) Myra E. van Linde et al. JOURNAL OF NEURO-ONCOLOGY
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
- (2017) Xiaoyang Lan et al. NATURE
- Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
- (2017) Xiuxing Wang et al. NATURE NEUROSCIENCE
- Prognostic relevance of genetic alterations in diffuse lower-grade gliomas
- (2017) Kosuke Aoki et al. NEURO-ONCOLOGY
- ACTR-46. AG-120, A FIRST-IN-class MUTANT IDH1 INHIBITOR IN PATIENTS WITH RECURRENT OR PROGRESSIVE IDH1 MUTANT GLIOMA: UPDATED RESULTS FROM THE PHASE 1 NON-ENHANCING GLIOMA POPULATION
- (2017) Ingo K Mellinghoff et al. NEURO-ONCOLOGY
- PRMT5 as a druggable target for glioblastoma therapy
- (2017) Yeshavanth Kumar Banasavadi-Siddegowda et al. NEURO-ONCOLOGY
- A randomized phase II study of everolimus in combination with chemoradiation in newly diagnosed glioblastoma: results of NRG Oncology RTOG 0913
- (2017) Prakash Chinnaiyan et al. NEURO-ONCOLOGY
- 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
- (2017) Parker L. Sulkowski et al. Science Translational Medicine
- Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
- (2017) Jong-Ho Lee et al. Nature Communications
- Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
- (2017) Georg Karpel-Massler et al. Nature Communications
- Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma
- (2017) Kiran K. Velpula et al. Oncotarget
- Recurrent glioma clinical trial, CheckMate-143: the game is not over yet
- (2017) Anna C. Filley et al. Oncotarget
- Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
- (2017) Andrea E. Calvert et al. Cell Reports
- Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells
- (2017) Jessica E. C. Jones et al. PLoS One
- The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
- (2016) David N. Louis et al. ACTA NEUROPATHOLOGICA
- Phase II study of atorvastatin in combination with radiotherapy and temozolomide In patients with glioblastoma (ART): interim analysis report
- (2016) A.K. Altwairgi et al. ANNALS OF ONCOLOGY
- Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis
- (2016) Daniel R. Wahl et al. CANCER RESEARCH
- Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2
- (2016) Ji Liang et al. CELL RESEARCH
- Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma
- (2016) K. Tateishi et al. CLINICAL CANCER RESEARCH
- Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis
- (2016) F. Geng et al. CLINICAL CANCER RESEARCH
- Gemcitabine Plus Radiation Therapy for High-Grade Glioma: Long-Term Results of a Phase 1 Dose-Escalation Study
- (2016) Michelle M. Kim et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Rapid Conversion of Mutant IDH1 from Driver to Passenger in a Model of Human Gliomagenesis
- (2016) T.-C. A. Johannessen et al. MOLECULAR CANCER RESEARCH
- Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of Glioblastoma
- (2016) Dan R. Laks et al. MOLECULAR CANCER THERAPEUTICS
- Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells
- (2016) Hua Lin et al. NEURO-ONCOLOGY
- Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma
- (2016) Jan C. Buckner et al. NEW ENGLAND JOURNAL OF MEDICINE
- An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
- (2016) Amit D. Gujar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
- (2016) Konstantinos J. Mavrakis et al. SCIENCE
- MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
- (2016) Gregory V. Kryukov et al. SCIENCE
- PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
- (2016) Ji Liang et al. Nature Communications
- Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma
- (2016) Alenoush Vartanian et al. Oncotarget
- Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth
- (2016) Peng Ru et al. Cell Reports
- MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
- (2016) Katya Marjon et al. Cell Reports
- Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
- (2016) Susana Romero-Garcia et al. Frontiers in Immunology
- Association of the Extent of Resection With Survival in Glioblastoma
- (2016) Timothy J. Brown et al. JAMA Oncology
- Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells
- (2016) Yuki Yasumoto et al. PLoS One
- IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO
- (2015) David E. Reuss et al. ACTA NEUROPATHOLOGICA
- Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status
- (2015) Dawn Q Chong et al. BMC CANCER
- Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
- (2015) Chunming Cheng et al. CANCER CELL
- Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion
- (2015) Kensuke Tateishi et al. CANCER CELL
- Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198
- (2015) R. J. Molenaar et al. CANCER RESEARCH
- IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism
- (2015) J. L. Izquierdo-Garcia et al. CANCER RESEARCH
- 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
- (2015) Xudong Fu et al. Cell Metabolism
- Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas
- (2015) M. Verreault et al. CLINICAL CANCER RESEARCH
- Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-type Glioma
- (2015) A. L. Di Stefano et al. CLINICAL CANCER RESEARCH
- Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway
- (2015) Lingqin Yuan et al. ENDOCRINE-RELATED CANCER
- Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma
- (2015) Roger Stupp et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment
- (2015) Kazuhiro Tanaka et al. JOURNAL OF CLINICAL INVESTIGATION
- Sensitization of Glioblastoma Cells to Irradiation by Modulating the Glucose Metabolism
- (2015) H. Shen et al. MOLECULAR CANCER THERAPEUTICS
- Lack of Evidence for PKM2 Protein Kinase Activity
- (2015) Aaron M. Hosios et al. MOLECULAR CELL
- SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance
- (2015) Dohoon Kim et al. NATURE
- Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
- (2015) Saverio Tardito et al. NATURE CELL BIOLOGY
- Prospects of immune checkpoint modulators in the treatment of glioblastoma
- (2015) Matthias Preusser et al. Nature Reviews Neurology
- Phase II study of PX-866 in recurrent glioblastoma
- (2015) M. W. Pitz et al. NEURO-ONCOLOGY
- Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis
- (2015) Antony Prabhu et al. NEURO-ONCOLOGY
- PD-L1 expression and prognostic impact in glioblastoma
- (2015) Edjah K. Nduom et al. NEURO-ONCOLOGY
- Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
- (2015) Jeanette E. Eckel-Passow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
- (2015) NEW ENGLAND JOURNAL OF MEDICINE
- Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
- (2015) S J H Ricoult et al. ONCOGENE
- Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer
- (2015) Deepak Sampath et al. PHARMACOLOGY & THERAPEUTICS
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
- (2015) J. Yun et al. SCIENCE
- Comprehensive Analysis of Glycolytic Enzymes as Therapeutic Targets in the Treatment of Glioblastoma
- (2015) Morgane Sanzey et al. PLoS One
- Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas
- (2014) Fred Fack et al. ACTA NEUROPATHOLOGICA
- Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
- (2014) Tomoyuki Mashimo et al. CELL
- Antiangiogenic Therapy for Glioblastoma: Current Status and Future Prospects
- (2014) T. T. Batchelor et al. CLINICAL CANCER RESEARCH
- Durable Therapeutic Efficacy Utilizing Combinatorial Blockade against IDO, CTLA-4, and PD-L1 in Mice with Brain Tumors
- (2014) D. A. Wainwright et al. CLINICAL CANCER RESEARCH
- Radiosensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific
- (2014) M. Leticia Castro et al. FREE RADICAL BIOLOGY AND MEDICINE
- Characterization of Cerebral Glutamine Uptake from Blood in the Mouse Brain: Implications for Metabolic Modeling of 13C NMR Data
- (2014) Puneet Bagga et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
- (2014) Susanne Grube et al. JOURNAL OF NEURO-ONCOLOGY
- The role of IDO in brain tumor immunotherapy
- (2014) Lijie Zhai et al. JOURNAL OF NEURO-ONCOLOGY
- Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs
- (2014) Pengfei Jiang et al. Journal of Translational Medicine
- EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma
- (2014) Michael Weller et al. LANCET ONCOLOGY
- Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma
- (2014) Robert T. Wicks et al. NEURO-ONCOLOGY
- Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma
- (2014) Anna Sophie Berghoff et al. NEURO-ONCOLOGY
- A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
- (2014) Mark R. Gilbert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma
- (2014) Olivier L. Chinot et al. NEW ENGLAND JOURNAL OF MEDICINE
- High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy
- (2014) Y. Ma et al. Science Translational Medicine
- EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing
- (2014) J. M. Francis et al. Cancer Discovery
- Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression
- (2014) J. P. Sullivan et al. Cancer Discovery
- Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer
- (2013) Krushna C. Patra et al. CANCER CELL
- The Somatic Genomic Landscape of Glioblastoma
- (2013) Cameron W. Brennan et al. CELL
- mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
- (2013) Kenta Masui et al. Cell Metabolism
- Phase II Study of Bevacizumab in Combination with Sorafenib in Recurrent Glioblastoma (N0776): A North Central Cancer Treatment Group Trial
- (2013) E. Galanis et al. CLINICAL CANCER RESEARCH
- Glioblastoma and Other Malignant Gliomas
- (2013) Antonio Omuro JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Reversing the Warburg Effect as a Treatment for Glioblastoma
- (2013) Ethan Poteet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased brain uptake and oxidation of acetate in heavy drinkers
- (2013) Lihong Jiang et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme
- (2013) Anna Rosati et al. NEURO-ONCOLOGY
- Lactate dehydrogenase A silencing in IDH mutant gliomas
- (2013) Charles Chesnelong et al. NEURO-ONCOLOGY
- Human Glioblastoma Multiforme: p53 Reactivation by a Novel MDM2 Inhibitor
- (2013) Barbara Costa et al. PLoS One
- Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma
- (2013) Lara Barazzuol et al. Radiation Oncology
- An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
- (2013) D. Rohle et al. SCIENCE
- K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
- (2012) Dong-Anh Khuong-Quang et al. ACTA NEUROPATHOLOGICA
- Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
- (2012) G. Jin et al. CANCER RESEARCH
- PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis
- (2012) Weiwei Yang et al. CELL
- Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo
- (2012) Isaac Marin-Valencia et al. Cell Metabolism
- Lipid metabolism in cancer
- (2012) Claudio R. Santos et al. FEBS Journal
- The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization
- (2012) Patrick S. Ward et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951
- (2012) Martin J. van den Bent et al. JOURNAL OF CLINICAL ONCOLOGY
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
- (2012) Peppi Koivunen et al. NATURE
- Passenger deletions generate therapeutic vulnerabilities in cancer
- (2012) Florian L. Muller et al. NATURE
- p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells
- (2012) L. Cen et al. NEURO-ONCOLOGY
- Metabolism of [U-13C]glucose in human brain tumorsin vivo
- (2012) Elizabeth A. Maher et al. NMR IN BIOMEDICINE
- Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
- (2012) Fabian V. Filipp et al. Pigment Cell & Melanoma Research
- A Radial Glia Gene Marker, Fatty Acid Binding Protein 7 (FABP7), Is Involved in Proliferation and Invasion of Glioblastoma Cells
- (2012) Antonella De Rosa et al. PLoS One
- Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma
- (2012) D. Singh et al. SCIENCE
- Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
- (2012) Dania Daye et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Effective Elimination of Cancer Stem Cells By a Novel Drug Combination Strategy
- (2012) Shuqiang Yuan et al. STEM CELLS
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Glioblastoma: From Molecular Pathology to Targeted Treatment
- (2011) Timothy F. Cloughesy et al. Annual Review of Pathology-Mechanisms of Disease
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells
- (2011) Yunfei Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin
- (2011) Albert Lai et al. JOURNAL OF CLINICAL ONCOLOGY
- Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
- (2011) Amparo Wolf et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
- (2011) Christian M. Metallo et al. NATURE
- Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme
- (2011) Amparo Wolf et al. NEUROBIOLOGY OF DISEASE
- Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH Mutations in Glioblastoma
- (2011) Daniel Krell et al. PLoS One
- Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
- (2011) T. Cheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma
- (2011) Olivier Keunen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway
- (2011) D. Guo et al. Cancer Discovery
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts
- (2010) K. Michaud et al. CANCER RESEARCH
- Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1
- (2010) M. J. Seltzer et al. CANCER RESEARCH
- Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer
- (2010) J. Du et al. CLINICAL CANCER RESEARCH
- Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies
- (2010) Mark Stein et al. PROSTATE
- Metabolic Modulation of Glioblastoma with Dichloroacetate
- (2010) E. D. Michelakis et al. Science Translational Medicine
- Glutamine addiction: a new therapeutic target in cancer
- (2010) David R. Wise et al. TRENDS IN BIOCHEMICAL SCIENCES
- Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
- (2009) Christian Hartmann et al. ACTA NEUROPATHOLOGICA
- In vitro and In vivo Radiosensitization of Glioblastoma Cells by the Poly (ADP-Ribose) Polymerase Inhibitor E7016
- (2009) A. L. Russo et al. CLINICAL CANCER RESEARCH
- Silencing of cytosolic NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances the sensitivity of HeLa cells toward staurosporine
- (2009) Su-Min Lee et al. FREE RADICAL RESEARCH
- Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: Present status and future prospects
- (2009) BS Dwarakanath et al. Journal of Cancer Research and Therapeutics
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
- (2009) Charles J. David et al. NATURE
- Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts
- (2009) J. Graeme Hodgson et al. NEURO-ONCOLOGY
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
- (2009) D. Guo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1
- (2009) S. Zhao et al. SCIENCE
- EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy
- (2009) D. Guo et al. Science Signaling
- Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer
- (2008) J. Sigmond et al. ANNALS OF ONCOLOGY
- Replication-Dependent Radiosensitization of Human Glioma Cells by Inhibition of Poly(ADP-Ribose) Polymerase: Mechanisms and Therapeutic Potential
- (2008) Fiona A. Dungey et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- Malignant Gliomas in Adults
- (2008) Patrick Y. Wen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started