Structure of nevanimibe-bound tetrameric human ACAT1

Structural basis for itraconazole-mediated NPC1 inhibition

(2020) Tao Long et al.   Nature Communications

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

(2019) Suzanne R. Pfeffer   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition

(2019) Tao Long et al.   Nature Communications

Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function

(2019) Yanqing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Crystal structure of a membrane-bound O-acyltransferase

(2018) Dan Ma et al.   NATURE

A fully automatic method yielding initial models from high-resolution cryo-electron microscopy maps

(2018) Thomas C. Terwilliger et al.   NATURE METHODS

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs

(2016) Christopher R. LaPensee et al.   ENDOCRINOLOGY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane bound O-acyltransferases and their inhibitors

(2015) Naoko Masumoto et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators

(2015) Maximillian A. Rogers et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

(2014) Xiaochun Li et al.   NATURE

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

(2011) Jingsong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Malformation syndromes caused by disorders of cholesterol synthesis

(2010) Forbes D. Porter et al.   JOURNAL OF LIPID RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Identification of putative active site residues of ACAT enzymes

(2008) Akash Das et al.   JOURNAL OF LIPID RESEARCH