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Title
Mechanisms and regulation of cholesterol homeostasis
Authors
Keywords
-
Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-12-18
DOI
10.1038/s41580-019-0190-7
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- (2019) Anil K. Padyana et al. Nature Communications
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- (2019) Jian Xiao et al. Science China-Life Sciences
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- (2019) Youngah Jo et al. eLife
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- (2019) Dilare Adi et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2018) Michael S. Brown et al. Annual Review of Biochemistry
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- (2018) Alina Fedoseienko et al. CIRCULATION RESEARCH
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- (2018) Sumihiko Hagita et al. Scientific Reports
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- (2018) Wataru Nihei et al. JOURNAL OF LIPID RESEARCH
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- (2009) C. Pramfalk et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2009) Gerd Schmitz et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2009) Joseph L. Goldstein et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
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- (2009) Hyock Joo Kwon et al. CELL
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- (2009) Hai Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Yukio Ikeda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Requirement of Myosin Vb·Rab11a·Rab11-FIP2 Complex in Cholesterol-regulated Translocation of NPC1L1 to the Cell Surface
- (2009) Bei-Bei Chu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Masato Irisawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation
- (2009) Steve Poirier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
- (2009) Jiang Wang et al. JOURNAL OF LIPID RESEARCH
- TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation
- (2009) Lei Lei et al. JOURNAL OF LIPID RESEARCH
- HNF1α and SREBP2 are important regulators of NPC1L1 in human liver
- (2009) Camilla Pramfalk et al. JOURNAL OF LIPID RESEARCH
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- (2009) Jayne S. Weiss OPHTHALMOLOGY
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- (2009) Noam Zelcer et al. SCIENCE
- Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance
- (2008) Arun Radhakrishnan et al. Cell Metabolism
- The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1
- (2008) Liang Ge et al. Cell Metabolism
- Identification of putative active site residues of ACAT enzymes
- (2008) Akash Das et al. JOURNAL OF LIPID RESEARCH
- Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux
- (2008) Sandhya Sankaranarayanan et al. JOURNAL OF LIPID RESEARCH
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- (2008) Jay D. Horton et al. JOURNAL OF LIPID RESEARCH
- Hepatic insulin resistance directly promotes formation of cholesterol gallstones
- (2008) Sudha B Biddinger et al. NATURE MEDICINE
- Extracellular loop C of NPC1L1 is important for binding to ezetimibe
- (2008) A. B. Weinglass et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular basis for LDL receptor recognition by PCSK9
- (2008) H. J. Kwon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
- (2008) D.-W. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coexistence of Foam Cells and Hypocholesterolemia in Mice Lacking the ABC Transporters A1 and G1
- (2007) Ruud Out et al. CIRCULATION RESEARCH
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