The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia

An overview of combined D-2- and L-2-hydroxyglutaric aciduria: functional analysis of CIC variants

(2017) Ana Pop et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Targeting Hypoxia to Improve Non–Small Cell Lung Cancer Outcome

(2017) Ahmed Salem et al.   JNCI-Journal of the National Cancer Institute

Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

(2017) Lei Jiang et al.   METABOLIC ENGINEERING

The Focinator v2-0 – Graphical Interface, Four Channels, Colocalization Analysis and Cell Phase Identification

(2017) Sebastian Oeck et al.   RADIATION RESEARCH

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

(2017) Parker L. Sulkowski et al.   Science Translational Medicine

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

(2017) Laurence M. Gagné et al.   TRENDS IN CELL BIOLOGY

Targeting Hypoxia to Improve Non–Small Cell Lung Cancer Outcome

(2017) Ahmed Salem et al.   JNCI-Journal of the National Cancer Institute

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

(2017) Ryota Nakashima et al.   Scientific Reports

Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia

(2016) Johann Matschke et al.   ANTIOXIDANTS & REDOX SIGNALING

Real-time Tumor Oxygenation Changes After Single High-dose Radiation Therapy in Orthotopic and Subcutaneous Lung Cancer in Mice: Clinical Implication for Stereotactic Ablative Radiation Therapy Schedule Optimization

(2016) Changhoon Song et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

(2016) Ana Latorre-Pellicer et al.   NATURE

Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia

(2016) Johann Matschke et al.   Radiation Oncology

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

The SLC25A1-p53 mutant crosstalk

(2015) Chris Albanese et al.   Aging-US

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

(2015) Dania C. Liemburg-Apers et al.   ARCHIVES OF TOXICOLOGY

Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation

(2015) Erika M. Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

(2015) William M. Oldham et al.   Cell Metabolism

The Focinator - a new open-source tool for high-throughput foci evaluation of DNA damage

(2015) Sebastian Oeck et al.   Radiation Oncology

Biology of Hypoxia

(2015) Paul N. Span et al.   SEMINARS IN NUCLEAR MEDICINE

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

(2015) Pu Wang et al.   Cell Reports

Cycling Hypoxia Induces a Specific Amplified Inflammatory Phenotype in Endothelial Cells and Enhances Tumor-Promoting Inflammation In Vivo

(2015) Céline Tellier et al.   NEOPLASIA

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

(2015) Olga Catalina-Rodriguez et al.   Oncotarget

SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker.

(2015) Vamsi K. Kolukula et al.   Oncotarget

A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation

(2014) Vittoria Infantino et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(2014) J. Ye et al.   Cancer Discovery

Imaging Tumor Hypoxia to Advance Radiation Oncology

(2013) Chen-Ting Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Paradigms and Future Challenges in Radiation Oncology: An Update of Biological Targets and Technology

(2013) S. L. Liauw et al.   Science Translational Medicine

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

(2012) Chii-Wen Chou et al.   NEURO-ONCOLOGY

RRM2B Suppresses Activation of the Oxidative Stress Pathway and is Up-regulated by P53 During Senescence

(2012) Mei-Ling Kuo et al.   Scientific Reports

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

‘Desperate house genes’: the dramatic example of hypoxia

(2010) J Caradec et al.   BRITISH JOURNAL OF CANCER

Imaging Cycling Tumor Hypoxia

(2010) S. Matsumoto et al.   CANCER RESEARCH

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

(2010) Julia Ling-Yu Chen et al.   PLoS Genetics

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibitors of the Mitochondrial Citrate Transport Protein: Validation of the Role of Substrate Binding Residues and Discovery of the First Purely Competitive Inhibitor

(2009) S. Aluvila et al.   MOLECULAR PHARMACOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE