Structure and mechanism of human diacylglycerol O-acyltransferase 1

Structure of an EIIC sugar transporter trapped in an inward-facing conformation

(2018) Zhenning Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acyl recognition and transfer by an integral membraneS-acyltransferase

(2018) Mitra S. Rana et al.   SCIENCE

Role of DGAT enzymes in triacylglycerol metabolism

(2018) Bhumika Bhatt-Wessel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Crystal structure of a membrane-bound O-acyltransferase

(2018) Dan Ma et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Diacylglycerol acyltransferase 1 is regulated by its N-terminal domain in response to allosteric effectors

(2017) Kristian Mark P Caldo et al.   PLANT PHYSIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

X-ray structure of a mammalian stearoyl-CoA desaturase

(2015) Yonghong Bai et al.   NATURE

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

Monoacylglycerol Acyltransferase-2 Is a Tetrameric Enzyme That Selectively Heterodimerizes with Diacylglycerol Acyltransferase-1

(2014) Jun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism

(2014) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

(2011) Jingsong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Topological Orientation of Acyl-CoA:Diacylglycerol Acyltransferase-1 (DGAT1) and Identification of a Putative Active Site Histidine and the Role of the N Terminus in Dimer/Tetramer Formation

(2010) Pamela J. McFie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

Identification of putative active site residues of ACAT enzymes

(2008) Akash Das et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

(2008) Gang Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY