Lipid Droplets in Health and Disease

The why, when and how of lipid droplet diversity

(2017) Abdou Rachid Thiam et al.   JOURNAL OF CELL SCIENCE

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

(2016) Susmita Kaushik et al.   Autophagy

Lipid droplet mobilization: The different ways to loosen the purse strings

(2016) Sabine D'Andrea   BIOCHIMIE

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue

(2016) Ambar Grijalva et al.   DIABETES

Function of Autophagy in Nonalcoholic Fatty Liver Disease

(2016) Mark J. Czaja   DIGESTIVE DISEASES AND SCIENCES

Protective role of autophagy in methionine–choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice

(2016) Rui Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of Liver Metabolism by Autophagy

(2016) Julio Madrigal-Matute et al.   GASTROENTEROLOGY

Lipid droplet–mediated ER homeostasis regulates autophagy and cell survival during starvation

(2016) Ariadna P. Velázquez et al.   JOURNAL OF CELL BIOLOGY

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement

(2016) Tingting Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of lipids in the metabolism and activation of immune cells

(2016) Merla J. Hubler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance

(2016) Ying Liu et al.   Scientific Reports

Morphologically and Functionally Distinct Lipid Droplet Subpopulations

(2016) Shuyan Zhang et al.   Scientific Reports

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Expanding Roles for Lipid Droplets

(2015) Michael A. Welte   CURRENT BIOLOGY

Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies

(2015) Ofer Moldavski et al.   DEVELOPMENTAL CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis

(2015) T. Shpilka et al.   EMBO JOURNAL

Chanarin-Dorfman syndrome: Genotype-Phenotype Correlation

(2015) Banu Guzel Nur et al.   European Journal of Medical Genetics

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

Ezetimibe ameliorates atherogenic lipids profiles, insulin resistance and hepatocyte growth factor in obese patients with hypercholesterolemia

(2015) Hisashi Adachi et al.   Lipids in Health and Disease

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Cytosolic lipid droplets: From mechanisms of fat storage to disease

(2014) David A. Gross et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

(2014) Nicolas Dupont et al.   CURRENT BIOLOGY

Lipid droplet biogenesis

(2014) Florian Wilfling et al.   CURRENT OPINION IN CELL BIOLOGY

On the Formation of Lipid Droplets in Human Adipocytes: The Organization of the Perilipin–Vimentin Cortex

(2014) Hans Heid et al.   PLoS One

The Proteome of Cholesteryl-Ester-Enriched Versus Triacylglycerol-Enriched Lipid Droplets

(2014) Victor K. Khor et al.   PLoS One

An ER Protein Functionally Couples Neutral Lipid Metabolism on Lipid Droplets to Membrane Lipid Synthesis in the ER

(2014) Daniel F. Markgraf et al.   Cell Reports

Novel Lipid Droplet–Associated Serine Hydrolase Regulates Macrophage Cholesterol Mobilization

(2013) Young-Hwa Goo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation

(2013) Analyn Lizaso et al.   Autophagy

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

Open Questions in Lipid Droplet Biology

(2013) Yuki Ohsaki et al.   CHEMISTRY & BIOLOGY

Balancing the fat: lipid droplets and human disease

(2013) Natalie Krahmer et al.   EMBO Molecular Medicine

Lipid droplet breakdown requires Dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes

(2013) Ryan J. Schulze et al.   JOURNAL OF CELL BIOLOGY

The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage

(2013) K. Thiel et al.   JOURNAL OF CELL SCIENCE

Cholesteryl ester storage disease: a rare and possibly treatable cause of premature vascular disease and cirrhosis

(2013) Tim Reynolds   JOURNAL OF CLINICAL PATHOLOGY

Autophagosomes contribute to intracellular lipid distribution in enterocytes

(2013) Salem Ait Khaldoun et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae

(2013) Tim van Zutphen et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in Alcohol-Induced Liver Diseases

(2012) Angela Dolganiuc et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Synergistic killing effect of chloroquine and androgen deprivation in LNCaP cells

(2012) Ramesh R. Kaini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of lipid stores and metabolism by lipophagy

(2012) K Liu et al.   CELL DEATH AND DIFFERENTIATION

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Controlling the size of lipid droplets: lipid and protein factors

(2012) Hongyuan Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Developmental changes in the protein composition of Manduca sexta lipid droplets

(2012) Jose L. Soulages et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress

(2012) Chandramohan Chitraju et al.   JOURNAL OF LIPID RESEARCH

The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans

(2012) Li Yang et al.   JOURNAL OF LIPID RESEARCH

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets

(2012) Anoop Kumar G. Velikkakath et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid Droplet De Novo Formation and Fission Are Linked to the Cell Cycle in Fission Yeast

(2012) Allan P. Long et al.   TRAFFIC

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Changes in Autophagic Response in Patients with Chronic Hepatitis C Virus Infection

(2011) Pierre-Emmanuel Rautou et al.   AMERICAN JOURNAL OF PATHOLOGY

The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristics

(2011) Julien Bouchoux et al.   BIOLOGY OF THE CELL

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

Human Lysophosphatidylcholine Acyltransferases 1 and 2 Are Located in Lipid Droplets Where They Catalyze the Formation of Phosphatidylcholine

(2011) Christine Moessinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Packaging of Fat: An Evolving Model of Lipid Droplet Assembly and Expansion

(2011) Dawn L. Brasaemle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

The role of lipid droplets in metabolic disease in rodents and humans

(2011) Andrew S. Greenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

A Thematic Review Series: Lipid droplet storage and metabolism: from yeast to man: Fig. 1.

(2011) Karen Reue   JOURNAL OF LIPID RESEARCH

Identification of the major functional proteins of prokaryotic lipid droplets

(2011) Yunfeng Ding et al.   JOURNAL OF LIPID RESEARCH

Proteome of Skeletal Muscle Lipid Droplet Reveals Association with Mitochondria and Apolipoprotein A-I

(2011) Huina Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Dysfunction of Autophagy Participates in Vacuole Formation and Cell Death in Cells Replicating Hepatitis C Virus

(2011) S. Taguwa et al.   JOURNAL OF VIROLOGY

Unique ties between hepatitis C virus replication and intracellular lipids

(2011) Eva Herker et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Not Just Fat: The Structure and Function of the Lipid Droplet

(2011) T. Fujimoto et al.   Cold Spring Harbor Perspectives in Biology

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Acyl-coenzyme A synthetases in metabolic control

(2010) Jessica M Ellis et al.   CURRENT OPINION IN LIPIDOLOGY

Molecular analysis of Chanarin-Dorfman syndrome (CDS) patients: Identification of novel mutations in the ABHD5 gene

(2010) Serap Emre et al.   European Journal of Medical Genetics

Lipid droplets lighting up: Insights from live microscopy

(2010) Margarete Digel et al.   FEBS LETTERS

Autophagy-related lipase FgATG15 of Fusarium graminearum is important for lipid turnover and plant infection

(2010) Long Nam Nguyen et al.   FUNGAL GENETICS AND BIOLOGY

Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice

(2010) Wen–Xing Ding et al.   GASTROENTEROLOGY

Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress

(2010) Yongjun Wang et al.   HEPATOLOGY

Lipid Droplet-associated Proteins Are Involved in the Biosynthesis and Hydrolysis of Triacylglycerol inMycobacterium bovisBacillus Calmette-Guérin

(2010) Kai Leng Low et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal Region of Comparative Gene Identification-58 (CGI-58) Is Important for Lipid Droplet Binding and Activation of Adipose Triglyceride Lipase

(2010) Astrid Gruber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Autophagy in Human Adipose Tissues in Obesity

(2010) Julia Kovsan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

(2010) V. M. Hubbard et al.   JOURNAL OF IMMUNOLOGY

Phospholipid demixing and the birth of a lipid droplet

(2010) J. Zanghellini et al.   JOURNAL OF THEORETICAL BIOLOGY

Intracellular Lipid Droplets Contain Dynamic Pools of Sphingomyelin: ADRP Binds Phospholipids with High Affinity

(2010) Avery L. McIntosh et al.   LIPIDS

Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression

(2010) Huajin Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism

(2010) Akiko Kuma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5

(2009) Martina Schweiger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipodystrophies: Disorders of adipose tissue biology

(2009) Abhimanyu Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

(2009) Perry E. Bickel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Coatomer-dependent protein delivery to lipid droplets

(2009) K. G. Soni et al.   JOURNAL OF CELL SCIENCE

Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects

(2009) Cédric M. Blouin et al.   JOURNAL OF LIPID RESEARCH

Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets

(2009) Brittany D. M. Hodges et al.   JOURNAL OF LIPID RESEARCH

Density functional computational studies on (E)-2-[(2-Hydroxy-5-nitrophenyl)-iminiomethyl]-4-nitrophenolate

(2009) Hasan Tanak et al.   JOURNAL OF MOLECULAR MODELING

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for lipid droplets in inter-membrane lipid traffic

(2009) John K. Zehmer et al.   PROTEOMICS

Protein composition of oil bodies from mature Brassica napus seeds

(2009) Pascale Jolivet et al.   PROTEOMICS

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

(2009) Marcelo M. Samsa et al.   PLoS Pathogens

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis

(2008) Antoni Paul et al.   CIRCULATION RESEARCH

Cell biology of lipid droplets

(2008) Christoph Thiele et al.   CURRENT OPINION IN CELL BIOLOGY

Minireview: Lipid Droplets in Lipogenesis and Lipolysis

(2008) Nicole A. Ducharme et al.   ENDOCRINOLOGY

Lipid droplets: a classic organelle with new outfits

(2008) Toyoshi Fujimoto et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria

(2008) Scot J. Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CGI-58, the Causative Gene for Chanarin-Dorfman Syndrome, Mediates Acylation of Lysophosphatidic Acid

(2008) Ananda K. Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fat-specific Protein 27 Regulates Storage of Triacylglycerol

(2008) Pernille Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100

(2008) Y. Ohsaki et al.   JOURNAL OF CELL SCIENCE

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE