CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

Mitochondrial localization, import and mitochondrial function of the androgen receptor

(2019) Prachi Bajpai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Metabolism Drives a Stromal Regenerative Response

(2019) Simon Schwörer et al.   Cell Metabolism

Lipid Metabolism and Endocrine Resistance in Prostate Cancer, and New Opportunities for Therapy

(2019) Gergana E. Stoykova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional genomic studies reveal the androgen receptor as a master regulator of cellular energy metabolism in prostate cancer

(2019) Kevin Gonthier et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cancer Metabolism and the Evasion of Apoptotic Cell Death

(2019) Aditi Sharma et al.   Cancers

CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions

(2019) Joshi et al.   Cells

CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis

(2019) Anne Skøttrup Mørkholt et al.   Scientific Reports

CPT1A regulates breast cancer-associated lymphangiogenesis via VEGF signaling

(2018) Yiquan Xiong et al.   BIOMEDICINE & PHARMACOTHERAPY

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B

(2018) Michel van Weeghel et al.   CARDIOVASCULAR RESEARCH

CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis

(2018) Ying-nan Wang et al.   ONCOGENE

Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle

(2018) Suzan J. G. Knottnerus et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers

(2018) Aziz Aiderus et al.   BMC CANCER

The p.P479L variant in CPT1A is associated with infectious disease in a BC First Nation

(2018) Graham Sinclair et al.   Paediatrics & Child Health

Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes

(2018) Gabriela Galicia-Vázquez et al.   Frontiers in Oncology

CPT1A-mediated succinylation of S100A10 increases human gastric cancer invasion

(2018) Chao Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity

(2018) Rosalía Rodríguez-Rodríguez et al.   Molecular Metabolism

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

(2018) Laura Moody et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Health effects of the CPT1A P479L variant: responsible public health policy

(2017) David M Koeller et al.   GENETICS IN MEDICINE

Carnitine palmitoyltransferase 1A P479L and infant death: policy implications of emerging data

(2017) Alison E. Fohner et al.   GENETICS IN MEDICINE

Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade

(2017) Thomas W. Flaig et al.   Oncotarget

The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders

(2016) Sander M. Houten et al.   Annual Review of Physiology

Combined defects in oxidative phosphorylation and fatty acid  -oxidation in mitochondrial disease

(2016) A. Nsiah-Sefaa et al.   BIOSCIENCE REPORTS

Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation

(2016) Cyril Corbet et al.   Cell Metabolism

Can Perhexiline Be Utilized Without Long-Term Toxicity? A Clinical Practice Audit

(2016) Helen Phuong et al.   THERAPEUTIC DRUG MONITORING

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

(2016) Q Qu et al.   Cell Death & Disease

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Differential epigenetic and transcriptional response of the skeletal muscle carnitine palmitoyltransferase 1B (CPT1B) gene to lipid exposure with obesity

(2015) Jill M. Maples et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

High fructose consumption induces DNA methylation at PPARα and CPT1A promoter regions in the rat liver

(2015) Koji Ohashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias

(2015) M. R. Ricciardi et al.   BLOOD

Nonstatin Therapies for Management of Dyslipidemia: A Review

(2015) Karen R. Sando et al.   CLINICAL THERAPEUTICS

Inhibition of Lipid Oxidation Increases Glucose Metabolism and Enhances 2-Deoxy-2-[18F]Fluoro-d-Glucose Uptake in Prostate Cancer Mouse Xenografts

(2015) Isabel R. Schlaepfer et al.   MOLECULAR IMAGING AND BIOLOGY

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

(2015) Isabel R. Schlaepfer et al.   Oncotarget

Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

(2015) Huanjie Shao et al.   Oncotarget

Mutation inCPT1CAssociated With Pure Autosomal Dominant Spastic Paraplegia

(2015) Carlo Rinaldi et al.   JAMA Neurology

Methylation at CPT1A locus is associated with lipoprotein subfraction profiles

(2014) Alexis C. Frazier-Wood et al.   JOURNAL OF LIPID RESEARCH

Lipid Catabolism via CPT1 as a Therapeutic Target for Prostate Cancer

(2014) I. R. Schlaepfer et al.   MOLECULAR CANCER THERAPEUTICS

Carnitine

(2014) Jack Odle et al.   Advances in Nutrition

Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is deficient

(2013) Sara Violante et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

(2013) S. Ramirez et al.   DIABETES

Carnitine-Acyltransferase System Inhibition, Cancer Cell Death, and Prevention of Myc-Induced Lymphomagenesis

(2013) Annalisa Pacilli et al.   JNCI-Journal of the National Cancer Institute

Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity

(2012) Gerald Maarman et al.   CARDIOVASCULAR DRUGS AND THERAPY

Independent Effects of Testosterone on Lipid Oxidation and VLDL-TG Production: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

(2012) C. Host et al.   DIABETES

Ceramide Levels Regulated by Carnitine Palmitoyltransferase 1C Control Dendritic Spine Maturation and Cognition

(2012) Patricia Carrasco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Receptor Alpha Interacts with Mitochondrial Protein HADHB and Affects Beta-Oxidation Activity

(2012) Zhenqi Zhou et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of Fatty Acid Metabolism Reduces Human Myeloma Cells Proliferation

(2012) José Manuel Tirado-Vélez et al.   PLoS One

Lipids and prostate cancer

(2012) Janel Suburu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis

(2011) R. Conti et al.   DIABETES

An Environment-dependent Structural Switch Underlies the Regulation of Carnitine Palmitoyltransferase 1A

(2011) Jampani N. Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex

(2011) Kwangwon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Testosterone or 17β-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes

(2011) Firoozeh Salehzadeh et al.   JOURNAL OF ENDOCRINOLOGY

Genetic polymorphisms incarnitine palmitoyltransferase 1Agene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos

(2011) Dominick J. Lemas et al.   JOURNAL OF LIPID RESEARCH

Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research

(2011) Simona M. Ceccarelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Strategies in Prostate Cancer: Targeting Lipogenic Pathways and the Energy Sensor AMPK

(2010) G. Zadra et al.   CLINICAL CANCER RESEARCH

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Peroxisome proliferator activated receptor α (PPARα) and PPAR gamma coactivator (PGC-1α) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements

(2010) Shulan Song et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Evidence for an Association Between Infant Mortality and a Carnitine Palmitoyltransferase 1A Genetic Variant

(2010) B. D. Gessner et al.   PEDIATRICS

Modulation of the hepatic malonyl-CoA–carnitine palmitoyltransferase 1A partnership creates a metabolic switch allowing oxidation ofde novofatty acids1

(2009) Marie Akkaoui et al.   BIOCHEMICAL JOURNAL

Structural insight into function and regulation of carnitine palmitoyltransferase

(2009) Arne C. Rufer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Carnitine palmitoyltransferase IA polymorphism P479L is common in Greenland Inuit and is associated with elevated plasma apolipoprotein A-I

(2009) Chandheeb Rajakumar et al.   JOURNAL OF LIPID RESEARCH

The paradox of the carnitine palmitoyltransferase type Ia P479L variant in Canadian Aboriginal populations

(2009) Cheryl R. Greenberg et al.   MOLECULAR GENETICS AND METABOLISM

CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity

(2008) Adriana Y. Sierra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer patterns in Inuit populations

(2008) Jeppe T Friborg et al.   LANCET ONCOLOGY