Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
Authors
Keywords
-
Journal
NATURE
Volume 581, Issue 7808, Pages 323-328
Publisher
Springer Science and Business Media LLC
Online
2020-05-14
DOI
10.1038/s41586-020-2289-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes
- (2019) Chandramohan Chitraju et al. JOURNAL OF LIPID RESEARCH
- The ghrelin O-acyltransferase structure reveals a catalytic channel for transmembrane hormone acylation
- (2019) Maria B. Campaña et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal structure of a membrane-bound O-acyltransferase
- (2018) Dan Ma et al. NATURE
- Identification and characterization of a novelDGAT1missense mutation associated with congenital diarrhea
- (2017) Nina L. Gluchowski et al. JOURNAL OF LIPID RESEARCH
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Diacylglycerol acyltransferase 1 is regulated by its N-terminal domain in response to allosteric effectors
- (2017) Kristian Mark P Caldo et al. PLANT PHYSIOLOGY
- Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures
- (2015) Heng Ru et al. CELL
- Purification and properties of recombinantBrassica napusdiacylglycerol acyltransferase 1
- (2015) Kristian Mark P. Caldo et al. FEBS LETTERS
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Acyl-CoA Metabolism and Partitioning
- (2014) Trisha J. Grevengoed et al. Annual Review of Nutrition
- Single particle electron cryo-microscopy of a mammalian ion channel
- (2014) Maofu Liao et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Deciphering key features in protein structures with the new ENDscript server
- (2014) Xavier Robert et al. NUCLEIC ACIDS RESEARCH
- Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety
- (2014) Shuwen He et al. ACS Medicinal Chemistry Letters
- Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
- (2013) Florian Wilfling et al. DEVELOPMENTAL CELL
- Acyltransferases in Bacteria
- (2013) A. Rottig et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- DGAT1 mutation is linked to a congenital diarrheal disorder
- (2012) Joel T. Haas et al. JOURNAL OF CLINICAL INVESTIGATION
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases
- (2011) Jingsong Cao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Bayesian View on Cryo-EM Structure Determination
- (2011) Sjors H.W. Scheres JOURNAL OF MOLECULAR BIOLOGY
- Human Fatty Liver Disease: Old Questions and New Insights
- (2011) J. C. Cohen et al. SCIENCE
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Topological Orientation of Acyl-CoA:Diacylglycerol Acyltransferase-1 (DGAT1) and Identification of a Putative Active Site Histidine and the Role of the N Terminus in Dimer/Tetramer Formation
- (2010) Pamela J. McFie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Acyl-coenzyme A:cholesterol acyltransferases
- (2009) Ta-Yuan Chang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis
- (2008) Chi-Liang Eric Yen et al. JOURNAL OF LIPID RESEARCH
- PROMALS3D: a tool for multiple protein sequence and structure alignments
- (2008) Jimin Pei et al. NUCLEIC ACIDS RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started