Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment

Adipocyte lipolysis and insulin resistance

(2016) Pauline Morigny et al.   BIOCHIMIE

p38  and p38  reprogram liver metabolism by modulating neutrophil infiltration

(2016) B. Gonzalez-Teran et al.   EMBO JOURNAL

Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss

(2016) J. Schmitz et al.   Molecular Metabolism

Recent insights on the role of cholesterol in non-alcoholic fatty liver disease

(2015) Graciela Arguello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis

(2015) R. Zechner   EMBO Molecular Medicine

FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies

(2015) Hong-Da Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TLR4 antagonist attenuates atherogenesis in LDL receptor-deficient mice with diet-induced type 2 diabetes

(2015) Zhongyang Lu et al.   IMMUNOBIOLOGY

Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice

(2015) K Schmitz et al.   INTERNATIONAL JOURNAL OF OBESITY

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

(2015) Kenny L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginase 2 deficiency results in spontaneous steatohepatitis: A novel link between innate immune activation and hepatic de novo lipogenesis

(2015) Laura A. Navarro et al.   JOURNAL OF HEPATOLOGY

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

Potential role for snoRNAs in PKR activation during metabolic stress

(2015) Osama A. Youssef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes

(2015) M. Furkan Burak et al.   Science Translational Medicine

Acyl-CoA Metabolism and Partitioning

(2014) Trisha J. Grevengoed et al.   Annual Review of Nutrition

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease

(2014) Nathalie Esser et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

(2014) Lay T. Gan et al.   JOURNAL OF HEPATOLOGY

Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity

(2014) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance

(2014) Nicola A. Talbot et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

(2014) Ana Paula Arruda et al.   NATURE MEDICINE

The endocannabinoid system controls food intake via olfactory processes

(2014) Edgar Soria-Gómez et al.   NATURE NEUROSCIENCE

Targeting inflammation in the treatment of type 2 diabetes: time to start

(2014) Marc Y. Donath   NATURE REVIEWS DRUG DISCOVERY

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms

(2014) Tomohiro Mita et al.   Obesity

IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis

(2014) Kimberly A. Negrin et al.   PLoS One

Increasing Fatty Acid Oxidation Remodels the Hypothalamic Neurometabolome to Mitigate Stress and Inflammation

(2014) Joseph W. McFadden et al.   PLoS One

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

(2014) Cristina Contreras et al.   Cell Reports

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

(2014) Lindsay E. Wu et al.   Molecular Metabolism

Immunological Goings-on in Visceral Adipose Tissue

(2013) Diane Mathis   Cell Metabolism

Metabolic Signaling in Fuel-Induced Insulin Secretion

(2013) Marc Prentki et al.   Cell Metabolism

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production

(2013) Haiming Cao et al.   Cell Metabolism

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

(2013) Matthew Spite et al.   Cell Metabolism

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice

(2013) T. Nakamura et al.   DIABETES

Induction of Cytosolic Phospholipase A 2 α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding

(2013) Nurit Hadad et al.   DIABETES

Targeting endoplasmic reticulum stress in metabolic disease

(2013) Stewart Siyan Cao et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

(2013) Peter Libby et al.   IMMUNITY

Adipocyte fatty acid-binding protein is released from adipocytes by a non-conventional mechanism

(2013) S Kralisch et al.   INTERNATIONAL JOURNAL OF OBESITY

Role of the intestinal microbiome in liver disease

(2013) Jorge Henao-Mejia et al.   JOURNAL OF AUTOIMMUNITY

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

(2013) Derrick M. Van Rooyen et al.   JOURNAL OF HEPATOLOGY

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

(2013) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms

(2013) Linnea R. Freeman et al.   NUTRITIONAL NEUROSCIENCE

Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population

(2013) Shutaro Ishimura et al.   PLoS One

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

(2013) M. Aouadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

(2013) T. Galbo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet inflammation: a unifying target for diabetes treatment?

(2013) Yumi Imai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and 1H-MR spectroscopy

(2012) Xin-Gui Peng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

(2012) Baojun Dong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Circulating Adipocyte Fatty Acid-Binding Protein Levels and Cardiovascular Morbidity and Mortality in Patients With Coronary Heart Disease

(2012) Maximilian von Eynatten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Lipid Metabolism and Toxicity in the Heart

(2012) Ira J. Goldberg et al.   Cell Metabolism

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure

(2012) Mingya Liu et al.   CLINICAL SCIENCE

Statins as Anti-Inflammatory Agents in Atherogenesis: Molecular Mechanisms and Lessons from the Recent Clinical Trials

(2012) Alexios S. Antonopoulos et al.   CURRENT PHARMACEUTICAL DESIGN

ER Stress as a Trigger for  -Cell Dysfunction and Autoimmunity in Type 1 Diabetes

(2012) B. O'Sullivan-Murphy et al.   DIABETES

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function

(2012) J. K. Kruit et al.   DIABETES

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

(2012) Fadila Benhamed et al.   JOURNAL OF CLINICAL INVESTIGATION

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

TNFα gene knockout differentially affects lipid deposition in liver and skeletal muscle of high-fat-diet mice

(2012) Jérôme Salles et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease

(2012) Stefan M. Nidorf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells

(2012) J. Y. Huh et al.   MOLECULAR AND CELLULAR BIOLOGY

SmD3 Regulates Intronic Noncoding RNA Biogenesis

(2012) B. S. Scruggs et al.   MOLECULAR AND CELLULAR BIOLOGY

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

The Role of TNF-α in Mice with Type 1- and 2- Diabetes

(2012) Maria Koulmanda et al.   PLoS One

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

(2012) L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

PKR-Dependent Inflammatory Signals

(2012) R. Kang et al.   Science Signaling

Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting

(2012) Suneng Fu et al.   PLoS Genetics

Systematic Review and Meta-Analysis of Methotrexate Use and Risk of Cardiovascular Disease

(2011) Renata Micha et al.   AMERICAN JOURNAL OF CARDIOLOGY

Tauroursodeoxycholic acid reduces endoplasmic reticulum stress, acinar cell damage, and systemic inflammation in acute pancreatitis

(2011) Ersin Seyhun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

log(TG)/HDL-C is related to both residual cardiometabolic risk and β-cell function loss in type 2 diabetes males

(2011) Michel P Hermans et al.   Cardiovascular Diabetology

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

(2011) Ryan G. Holzer et al.   CELL

Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress

(2011) Carlos I. Michel et al.   Cell Metabolism

FABP 4 is associated with inflammatory markers and metabolic syndrome in morbidly obese women

(2011) Ximena Terra et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

(2011) Michael J. Jurczak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis

(2011) Lei Zhao et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Serum Levels of Adipocyte Fatty Acid-Binding Protein Are Associated with the Severity of Coronary Artery Disease in Chinese Women

(2011) Yuqian Bao et al.   PLoS One

Serum Fatty Acid-Binding Protein 4 Is a Predictor of Cardiovascular Events in End-Stage Renal Disease

(2011) Masato Furuhashi et al.   PLoS One

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High fat diet induced diabetic cardiomyopathy

(2011) Ellen Dirkx et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

(2011) Saswata Talukdar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound

(2010) Toru Miyoshi et al.   ATHEROSCLEROSIS

Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects

(2010) Anne Sofie Andreasen et al.   BRITISH JOURNAL OF NUTRITION

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Fasting Serum Level of Fatty-Acid-Binding Protein 4 Positively Correlates With Metabolic Syndrome in Patients With Coronary Artery Disease

(2010) Bang-Gee Hsu et al.   CIRCULATION JOURNAL

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

(2010) Y Kadooka et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with18F-Fluorodeoxyglucose Positron Emission Tomography

(2010) Hye Jin Yoo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity

(2010) Piia Simonen et al.   JOURNAL OF HEPATOLOGY

Serum adipocyte-specific fatty acid-binding protein is associated with nonalcoholic fatty liver disease in apparently healthy subjects

(2010) Young-Choon Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Diet-genotype interactions in the early development of obesity and insulin resistance in mice with a genetic deficiency in tumor necrosis factor–α

(2010) Brenda Bouter et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin

(2010) C. L. Gentile et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Changes in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice

(2010) Jae-Seong Yang et al.   PLoS One

Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia–reperfusion

(2010) I Ben Mosbah et al.   Cell Death & Disease

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages

(2009) K. H. Han et al.   CARDIOVASCULAR RESEARCH

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Adipocyte Fatty Acid–Binding Protein Suppresses Cardiomyocyte Contraction

(2009) Valéria Lamounier-Zepter et al.   CIRCULATION RESEARCH

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL

DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity

(2009) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis

(2009) Songwen Zhang et al.   JOURNAL OF HEPATOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes

(2009) Marc Y. Donath et al.   PHYSIOLOGY

Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids

(2009) Ludovic Pineau et al.   TRAFFIC

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake

(2008) Matthew P. Gillum et al.   CELL

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss

(2008) M. F. Gregor et al.   DIABETES

Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals

(2008) G. Boden et al.   DIABETES

Blockade of Tumor Necrosis Factor (TNF) Receptor Type 1-Mediated TNF-α Signaling Protected Wistar Rats from Diet-Induced Obesity and Insulin Resistance

(2008) Huifang Liang et al.   ENDOCRINOLOGY

Anti-Inflammatory Action of a Phosphatidylcholine, Phosphatidylethanolamine and N-Acylphosphatidylethanolamine-Enriched Diet in Carrageenan-Induced Pleurisy

(2008) G. Erõs et al.   EUROPEAN SURGICAL RESEARCH

Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons

(2008) Charles P. Lambert et al.   JOURNAL OF APPLIED PHYSIOLOGY

Inhibitory effect of N-palmitoylphosphatidylethanolamine on macrophage phagocytosis through inhibition of Rac1 and Cdc42

(2008) A. Shiratsuchi et al.   JOURNAL OF BIOCHEMISTRY

Cholesterol in islet dysfunction and type 2 diabetes

(2008) Liam R. Brunham et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

(2008) Kaori Minehira et al.   JOURNAL OF LIPID RESEARCH

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

(2007) Yongzhong Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY