Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the Development of Pathological States—Current View of Knowledge

Pharmacology of Free Fatty Acid Receptors and Their Allosteric Modulators

(2021) Manuel Grundmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

(2020) Sara Jiménez-González et al.   Cells

Carnitine palmitoyltransferase 2 (CPT2) knockout potentiates palmitate‐induced insulin resistance in C2C12 myotubes

(2020) Michael L. Blackburn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1)

(2020) Tsunehisa Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTORC1-IRE1α pathway activation contributes to palmitate-elicited triglyceride secretion and cell death in hepatocytes

(2020) Jun Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells

(2020) Yunxia Zhu et al.   Frontiers in Endocrinology

Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells

(2020) Mst Mamuna Sharmin et al.   JOURNAL OF DAIRY SCIENCE

Inositol requiring enzyme 1 alpha (IRE1a) links palmitate-induced mTOR activation and lipotoxicity in Hepatocytes

(2020) Yingli Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Prolonged Lipid Accumulation in Cultured Primary Human Hepatocytes Rather Leads to ER Stress than Oxidative Stress

(2020) Christiane Rennert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute effects of fatty acids on autophagy in NPY neurones

(2020) Andressa Reginato et al.   JOURNAL OF NEUROENDOCRINOLOGY

Palmitate-induced toxicity is associated with impaired mitochondrial respiration and accelerated oxidative stress in cultured cardiomyocytes: The critical role of coenzyme Q9/10

(2020) Phiwayinkosi V. Dludla et al.   TOXICOLOGY IN VITRO

Palmitic acid‑induced autophagy increases reactive oxygen species via the Ca2+/PKCα/NOX4 pathway and impairs endothelial function in human umbilical vein endothelial cells

(2019) Pan Chen et al.   Experimental and Therapeutic Medicine

Nupr1 regulates palmitate-induced apoptosis in human articular chondrocytes

(2019) Li Tan et al.   BIOSCIENCE REPORTS

Palmitate decreases migration and proliferation and increases oxidative stress and inflammation in smooth muscle cells. Role of the Nrf2 signaling pathway

(2019) Josefa Girona et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oxidative and endoplasmic reticulum stresses are involved in palmitic acid-induced H9c2 cell apoptosis

(2019) Lei Yang et al.   BIOSCIENCE REPORTS

Palmitic Acid and β-Hydroxybutyrate Induce Inflammatory Responses in Bovine Endometrial Cells by Activating Oxidative Stress-Mediated NF-κB Signaling

(2019) Peng Li et al.   MOLECULES

Oxidative stress induced by palmitic acid modulates KCa2.3 channels in vascular endothelium

(2019) Yan Wang et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury

(2019) Tun Nyunt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid

(2019) Arwa Alnahdi et al.   Nutrients

Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells

(2019) Asie Sadeghi et al.   CYTOKINE

Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes†

(2018) Nobuhiko Itami et al.   BIOLOGY OF REPRODUCTION

Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response

(2018) Thitinun Anusornvongchai et al.   KIDNEY INTERNATIONAL

Palmitate-induced Slc2a4/GLUT4 downregulation in L6 muscle cells: evidence of inflammatory and endoplasmic reticulum stress involvement

(2018) Patrícia Ebersbach-Silva et al.   Lipids in Health and Disease

Mitochondrial β-oxidation of saturated fatty acids in humans

(2018) María M. Adeva-Andany et al.   MITOCHONDRION

Lipotoxic Effects of Palmitic Acid on Astrocytes Are Associated with Autophagy Impairment

(2018) Ana Ortiz-Rodriguez et al.   MOLECULAR NEUROBIOLOGY

Palmitic acid triggers inflammatory responses in N42 cultured hypothalamic cells partially via ceramide synthesis but not via TLR4

(2018) Domenico Sergi et al.   NUTRITIONAL NEUROSCIENCE

Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages

(2018) Hui Li et al.   Frontiers in Immunology

Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy

(2018) Lei Yang et al.   CELL STRESS & CHAPERONES

Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release

(2018) Junjiang Pan et al.   CELLULAR IMMUNOLOGY

Increased Apoptosis in High-Fat Diet–Induced Nonalcoholic Steatohepatitis in Rats Is Associated with c-Jun NH2-Terminal Kinase Activation and Elevated Proapoptotic Bax

(2018) Yan Wang et al.   JOURNAL OF NUTRITION

Astragaloside IV inhibits palmitate-mediated oxidative stress and fibrosis in human glomerular mesangial cells via downregulation of CD36 expression

(2018) Yong Su et al.   Pharmacological Reports

Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts

(2017) Ali Akoumi et al.   EXPERIMENTAL CELL RESEARCH

Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid–induced insulin resistance

(2017) Satoko Shinjo et al.   EXPERIMENTAL CELL RESEARCH

Lipotoxicity-Induced PRMT1 Exacerbates Mesangial Cell Apoptosis via Endoplasmic Reticulum Stress

(2017) Min-Jung Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Palmitate induces myocardial lipotoxic injury via the endoplasmic reticulum stress-mediated apoptosis pathway

(2017) Lu Zou et al.   Molecular Medicine Reports

Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice

(2017) You-Jin Choi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Overexpression of heart-type fatty acid binding protein enhances fatty acid-induced podocyte�injury

(2017) Qing Gao et al.   Experimental and Therapeutic Medicine

Involvement of receptor-interacting protein 140 in palmitate-stimulated macrophage infiltration of pancreatic beta cells

(2017) Runmei Zou et al.   Experimental and Therapeutic Medicine

Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins

(2017) Pablo Esteban Morales et al.   Journal of Diabetes Research

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

(2017) Gianfranca Carta et al.   Frontiers in Physiology

Macrophage alternative activation confers protection against lipotoxicity-induced cell death

(2017) Lingling Dai et al.   Molecular Metabolism

Palmitate and oleate exert differential effects on insulin signalling and glucose uptake in human skeletal muscle cells

(2017) Selina Mäkinen et al.   Endocrine Connections

Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes

(2016) Frédéric Capel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Toll-like receptor 2 and type 2 diabetes

(2016) Zahra Sepehri et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Lipotoxic Palmitate Impairs the Rate of β-Oxidation and Citric Acid Cycle Flux in Rat Neonatal Cardiomyocytes

(2016) Taha Haffar et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Crucial Role of C18-Cer in Fat-Induced Skeletal Muscle Insulin Resistance

(2016) Agnieszka U. Blachnio-Zabielska et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain

(2016) Gurdeep Marwarha et al.   CELLULAR SIGNALLING

Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein β–CCAAT-enhancer-binding protein α activation

(2016) Jianghong Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

(2016) P S Dalvi et al.   INTERNATIONAL JOURNAL OF OBESITY

Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways

(2016) Hnin Hnin Aung et al.   JOURNAL OF LIPID RESEARCH

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Free fatty acid palmitate activates unfolded protein response pathway and promotes apoptosis in meniscus cells

(2016) J. Haywood et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

(2016) Leroy C. Joseph et al.   PLoS One

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

Par-4/NF-κB Mediates the Apoptosis of IsletβCells Induced by Glucolipotoxicity

(2016) Wu QiNan et al.   Journal of Diabetes Research

Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin

(2015) Jeong-a Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin resistance caused by lipotoxicity is related to oxidative stress and endoplasmic reticulum stress in LPL gene knockout heterozygous mice

(2015) Yang-Xue Li et al.   ATHEROSCLEROSIS

Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells

(2015) Sergio Wehinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Palmitate-Induced Impairments of β-Cell Function Are Linked With Generation of Specific Ceramide Species via Acylation of Sphingosine

(2015) Levon Manukyan et al.   ENDOCRINOLOGY

Acylcarnitines: potential implications for skeletal muscle insulin resistance

(2015) Céline Aguer et al.   FASEB JOURNAL

Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection

(2015) Virginia Pardo et al.   FOOD AND CHEMICAL TOXICOLOGY

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

Palmitate differentially regulates the polarization of differentiating and differentiated macrophages

(2015) Fangming Xiu et al.   IMMUNOLOGY

Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation

(2015) JIAJING YIN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nox2 Mediates Skeletal Muscle Insulin Resistance Induced by a High Fat Diet

(2015) Alvaro Souto Padron de Figueiredo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation

(2015) Virginia Pardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress–Induced IRE1α Activation Mediates Cross-Talk of GSK-3β and XBP-1 To Regulate Inflammatory Cytokine Production

(2015) Sena Kim et al.   JOURNAL OF IMMUNOLOGY

Palmitate induces cisternal ER expansion via the activation of XBP-1/CCTα-mediated phospholipid accumulation in RAW 264.7 cells

(2015) Seong Keun Kim et al.   Lipids in Health and Disease

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

(2015) S Xu et al.   Cell Death & Disease

Lipotoxic Stress Induces Pancreaticβ-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System

(2015) Sara A. Litwak et al.   Journal of Diabetes Research

CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

(2015) Wei Hua et al.   PLoS One

In vitrotreatment of HepG2 cells with saturated fatty acids reproduces mitochondrial dysfunction found in nonalcoholic steatohepatitis

(2014) Inmaculada García-Ruiz et al.   Disease Models & Mechanisms

Calcium Efflux From the Endoplasmic Reticulum Leads to β-Cell Death

(2014) Takashi Hara et al.   ENDOCRINOLOGY

Palmitic Acid-Induced Neuron Cell Cycle G2/M Arrest and Endoplasmic Reticular Stress through Protein Palmitoylation in SH-SY5Y Human Neuroblastoma Cells

(2014) Yung-Hsuan Hsiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

(2014) Shakeel U. R. Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans

(2014) David Patsouris et al.   PLoS One

Uncoupling Protein 2 Regulates Palmitic Acid-Induced Hepatoma Cell Autophagy

(2014) Jiaxin Lou et al.   Biomed Research International

ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

(2014) Robert A. Egnatchik et al.   Molecular Metabolism

Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin

(2013) Hyun-Ju Jang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells

(2013) Jonathan Barlow et al.   BIOCHEMICAL JOURNAL

Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity

(2013) Baggavalli P Somesh et al.   BMC CELL BIOLOGY

Mitochondrial Substrate Availability and Its Role in Lipid-Induced Insulin Resistance and Proinflammatory Signaling in Skeletal Muscle

(2013) C. Lipina et al.   DIABETES

Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway

(2013) Annalisa Natalicchio et al.   DIABETOLOGIA

Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

(2013) Quan Qiu et al.   EMBO JOURNAL

FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

(2013) Hjalti Kristinsson et al.   ENDOCRINOLOGY

Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways

(2013) Sena Kim et al.   Innate Immunity

Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway

(2013) YING-YING CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

(2013) Ebru Boslem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasome-Mediated Secretion of IL-1  in Human Monocytes through TLR2 Activation; Modulation by Dietary Fatty Acids

(2013) R. G. Snodgrass et al.   JOURNAL OF IMMUNOLOGY

Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate

(2013) Katherine Macrae et al.   JOURNAL OF LIPID RESEARCH

Fatty acid-mediated endoplasmic reticulum stress in vivo: Differential response to the infusion of Soybean and Lard Oil in rats

(2013) Angela M. Nivala et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells

(2013) Ximei Shen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitochondrial DNA Damage via Augmented Oxidative Stress Regulates Endoplasmic Reticulum Stress and Autophagy: Crosstalk, Links and Signaling

(2013) Larysa V. Yuzefovych et al.   PLoS One

Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death

(2013) Tongfang Tang et al.   PLoS One

Evidence for the involvement of GPR40 and NADPH oxidase in palmitic acid-induced superoxide production and insulin secretion

(2013) Maria Fernanda Graciano et al.   Islets

Structural and biochemical characteristics of various white adipose tissue depots

(2012) A. Wronska et al.   Acta Physiologica

A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death

(2012) Aaron C. Baldwin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status

(2012) H. Kitade et al.   DIABETES

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human  -Cell Apoptosis

(2012) D. A. Cunha et al.   DIABETES

Induction of Autophagy by Palmitic Acid via Protein Kinase C-mediated Signaling Pathway Independent of mTOR (Mammalian Target of Rapamycin)

(2012) Shi Hao Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes

(2012) Sarah Brice Russo et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death through a TRIF-Dependent Pathway

(2012) J. D. Schilling et al.   JOURNAL OF IMMUNOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Inhibition of uncoupling protein 2 with genipin exacerbates palmitate-induced hepatic steatosis

(2012) Shuangtao Ma et al.   Lipids in Health and Disease

Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells

(2012) Yong Zhang et al.   Lipids in Health and Disease

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

(2012) Jie Cao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets

(2012) Luisa Martino et al.   PLoS One

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

(2011) Zhen Wang et al.   BRITISH JOURNAL OF NUTRITION

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans

(2011) P.-M. Badin et al.   DIABETES

Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)–nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction

(2011) R. Barazzoni et al.   DIABETOLOGIA

Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells

(2011) R. Hage Hassan et al.   DIABETOLOGIA

Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice

(2011) W. Quan et al.   DIABETOLOGIA

Stimulation of Lipogenesis as Well as Fatty Acid Oxidation Protects against Palmitate-Induced INS-1 β-Cell Death

(2011) Sung-E. Choi et al.   ENDOCRINOLOGY

Oleate Blocks Palmitate-Induced Abnormal Lipid Distribution, Endoplasmic Reticulum Expansion and Stress, and Insulin Resistance in Skeletal Muscle

(2011) Gong Peng et al.   ENDOCRINOLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways

(2011) Ting-Fang Kuo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of survival and apoptotic signaling pathways in lymphocytes exposed to palmitic acid

(2011) Hilton Kenji Takahashi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long- and Medium-Chain Fatty Acids Induce Insulin Resistance to a Similar Extent in Humans Despite Marked Differences in Muscle Fat Accumulation

(2011) Joris Hoeks et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets

(2011) Jiong Li et al.   JOURNAL OF HEPATOLOGY

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

Involvement of the TLR4 (Toll-like receptor4) signaling pathway in palmitate-induced INS-1 beta cell death

(2011) Sung-Mi Lee et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε

(2011) Girish Kewalramani et al.   PLoS One

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis

(2010) Louise Deldicque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway

(2010) Koji Komiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipotoxicity, fatty acid uncoupling and mitochondrial carrier function

(2010) Eduardo Rial et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells

(2010) Michalis D. Mantzaris et al.   FEBS Journal

Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways

(2010) Elias Katsoulieris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells

(2010) J.C. Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets

(2010) Laurence Ladrière et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis

(2010) Yuko Akazawa et al.   JOURNAL OF HEPATOLOGY

Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells

(2010) Xuemei Gu et al.   LIFE SCIENCES

Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis

(2010) Lars P. Bechmann et al.   LIVER INTERNATIONAL

Palmitate induces C-reactive protein expression in human aortic endothelial cells. Relevance to fatty acid–induced endothelial dysfunction

(2010) Yves Mugabo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids

(2010) Alexander Krogmann et al.   MICROVASCULAR RESEARCH

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Alterations in Fatty Acid Utilization and an Impaired Antioxidant Defense Mechanism Are Early Events in Podocyte Injury

(2009) Corina Mayrhofer et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in β-cells

(2009) Kamila S. Gwiazda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways

(2009) Rafik Ragheb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload

(2009) A. M. Preston et al.   DIABETOLOGIA

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

The c-Jun N-Terminal Kinase Mediates the Induction of Oxidative Stress and Insulin Resistance by Palmitate and Toll-like Receptor 2 and 4 Ligands in 3T3-L1 Adipocytes

(2009) J. Davis et al.   HORMONE AND METABOLIC RESEARCH

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JNK1-dependent PUMA Expression Contributes to Hepatocyte Lipoapoptosis

(2009) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

(2009) Sandro M. Hirabara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy

(2009) R. Lennon et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids

(2009) Joo Y Lee et al.   NUTRITION REVIEWS

JNK- and IκB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro

(2008) Kazuto Takahashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells

(2008) Victor Samokhvalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

(2008) Maria L. Watson et al.   BIOCHEMICAL JOURNAL

Oxidative stress as regulatory factor for fatty-acid-induced uncoupling involving liver mitochondrial ADP/ATP and aspartate/glutamate antiporters of old rats

(2008) V. N. Samartsev et al.   BIOCHEMISTRY-MOSCOW

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet-Induced Insulin Resistance

(2008) C. R. Bruce et al.   DIABETES

Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of  -Oxidation Products Because of Impaired Fatty Acid Oxidation: Effects of Tetradecylthioacetic Acid and Eicosapentaenoic Acid

(2008) A. J. Wensaas et al.   DIABETES

Inhibition of Foxo1 Protects Pancreatic Islet  -Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

(2008) S. C. Martinez et al.   DIABETES

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES

Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death

(2008) Sung-E Choi et al.   ENDOCRINOLOGY

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Prevention of free fatty acid-induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways

(2008) Xudong Wu et al.   HEPATOLOGY

Saturated Fatty Acids Inhibit Hepatic Insulin Action by Modulating Insulin Receptor Expression and Post-receptor Signalling

(2008) M. W. Ruddock et al.   JOURNAL OF BIOCHEMISTRY

Oleate Reverses Palmitate-induced Insulin Resistance and Inflammation in Skeletal Muscle Cells

(2008) Teresa Coll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of Hepatic Fatty Acid Transporter Protein 5in VivoReverses Diet-induced Non-alcoholic Fatty Liver Disease and Improves Hyperglycemia

(2008) Holger Doege et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells

(2008) A.S. Pimenta et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Palmitate increases superoxide production through mitochondrial electron transport chain and NADPH oxidase activity in skeletal muscle cells

(2008) Rafael Herling Lambertucci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential regulation of the endoplasmic reticulum stress response in pancreatic β-cells exposed to long-chain saturated and monounsaturated fatty acids

(2008) Eleftheria Diakogiannaki et al.   JOURNAL OF ENDOCRINOLOGY

Acute elevation of circulating fatty acids impairs downstream insulin signalling in rat skeletal muscle in vivo independent of effects on stress signalling

(2008) Georgia Frangioudakis et al.   JOURNAL OF ENDOCRINOLOGY