Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

(2016) Geraldine Harriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cellsex vivothrough inhibition ofde novolipogenesis

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Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

(2015) Jia Wei et al.   NATURE

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

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Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells

(2014) Caroline A. Lewis et al.   MOLECULAR CELL

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

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Cellular Fatty Acid Metabolism and Cancer

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

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AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

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Hallmarks of Cancer: The Next Generation

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Acetyl-CoA carboxylase-α inhibitor TOFA induces human cancer cell apoptosis

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Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK

(2009) Yong Soon Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

(2009) S. Fogarty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sunitinib Prolongs Survival in Genetically Engineered Mouse Models of Multistep Lung Carcinogenesis

(2009) L. Gandhi et al.   Cancer Prevention Research

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Fatty acid metabolism: target for metabolic syndrome

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