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Title
Metabolic regulation of ferroptosis in the tumor microenvironment
Authors
Keywords
ferroptosis, cancer, tumor microenvironment, metabolism, tumor immunity
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume -, Issue -, Pages 101617
Publisher
Elsevier BV
Online
2022-01-21
DOI
10.1016/j.jbc.2022.101617
References
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Related references
Note: Only part of the references are listed.- Ferroptosis: mechanisms, biology and role in disease
- (2021) Xuejun Jiang et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Characteristics and Biomarkers of Ferroptosis
- (2021) Xin Chen et al. Frontiers in Cell and Developmental Biology
- Metabolic Regulation of Ferroptosis in Cancer
- (2021) Min Ji Kim et al. Biology-Basel
- CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
- (2021) Xingzhe Ma et al. Cell Metabolism
- A compendium of kinetic modulatory profiles identifies ferroptosis regulators
- (2021) Megan Conlon et al. Nature Chemical Biology
- PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis
- (2021) Xinxin Song et al. Cell Reports
- Oxidative Stress in the Tumor Microenvironment and Its Relevance to Cancer Immunotherapy
- (2021) Nada S. Aboelella et al. Cancers
- Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition
- (2021) George Sharbeen et al. CANCER RESEARCH
- Erastin synergizes with cisplatin via ferroptosis to inhibit ovarian cancer growth in vitro and in vivo
- (2021) Qi Cheng et al. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
- DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
- (2021) Chao Mao et al. NATURE
- Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity
- (2021) Guang Lei et al. ONCOGENE
- Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
- (2021) Shihao Xu et al. IMMUNITY
- Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer
- (2021) Jingjing Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism
- (2021) Jing Du et al. Cell Death & Disease
- GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
- (2021) Daniel M. Kremer et al. Nature Communications
- Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers
- (2020) Ling F. Ye et al. ACS Chemical Biology
- Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein
- (2020) Enyong Dai et al. Autophagy
- The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
- (2020) Guang Lei et al. CELL RESEARCH
- ROS in cancer therapy: the bright side of the moon
- (2020) Bruno Perillo et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Energy-stress-mediated AMPK activation inhibits ferroptosis
- (2020) Hyemin Lee et al. NATURE CELL BIOLOGY
- Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death
- (2020) Yang Liu et al. CANCER GENE THERAPY
- Cysteine depletion induces pancreatic tumor ferroptosis in mice
- (2020) Michael A. Badgley et al. SCIENCE
- Transferrin Receptor Is a Specific Ferroptosis Marker
- (2020) Huizhong Feng et al. Cell Reports
- Oxidative Stress in Cancer
- (2020) John D. Hayes et al. CANCER CELL
- Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells
- (2020) Marcos A. Perez et al. DEVELOPMENTAL CELL
- Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
- (2020) Rong Tang et al. Journal of Hematology & Oncology
- Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
- (2020) Mariluz Soula et al. Nature Chemical Biology
- Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer
- (2020) Kaylyn D. Tousignant et al. Cancer & Metabolism
- Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells
- (2020) Kang Wang et al. CELL DEATH AND DIFFERENTIATION
- Lymph protects metastasizing melanoma cells from ferroptosis
- (2020) Jessalyn M. Ubellacker et al. NATURE
- Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
- (2020) Yilong Zou et al. NATURE
- The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension
- (2020) Warren L. Wu et al. MOLECULAR CELL
- 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
- (2020) Nobuaki Takahashi et al. MOLECULAR CELL
- Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway
- (2020) Enyong Dai et al. Nature Communications
- HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications
- (2020) Youbo Zhao et al. Cell Reports
- NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
- (2019) Matthew Dodson et al. Redox Biology
- Improving the metabolic fidelity of cancer models with a physiological cell culture medium
- (2019) Johan Vande Voorde et al. Science Advances
- The release and activity of HMGB1 in ferroptosis
- (2019) Qirong Wen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
- (2019) Ishraq Alim et al. CELL
- Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
- (2019) Guo-Qing Chen et al. CELL DEATH AND DIFFERENTIATION
- Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
- (2019) Xingzhe Ma et al. Cell Metabolism
- CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
- (2019) Weimin Wang et al. NATURE
- Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53
- (2019) Julia I-Ju Leu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells
- (2019) Shiyao Sui et al. Cell Death & Disease
- Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability
- (2019) Mark R Sullivan et al. eLife
- Nrf2 in cancers: A double‐edged sword
- (2019) Shijia Wu et al. Cancer Medicine
- Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses
- (2019) Boutaina Daher et al. CANCER RESEARCH
- Immunogenic cell death in cancer therapy: Present and emerging inducers
- (2019) Jingyi Zhou et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
- (2019) Jiao Wu et al. NATURE
- Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells
- (2019) Kang Wang et al. Drug Design Development and Therapy
- Sigma‐1 receptor protects against ferroptosis in hepatocellular carcinoma cells
- (2019) Tao Bai et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
- (2019) Xueting Lang et al. Cancer Discovery
- The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma
- (2019) Wen-Hsuan Yang et al. Cell Reports
- Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy
- (2019) Yuji Otsuki et al. CANCER SCIENCE
- A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering
- (2019) Tsz-Leung To et al. CELL
- Mitochondria regulation in ferroptosis
- (2019) Hai Wang et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- FSP1 is a glutathione-independent ferroptosis suppressor
- (2019) Sebastian Doll et al. NATURE
- The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
- (2019) Kirill Bersuker et al. NATURE
- Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo
- (2019) Yuki Shibata et al. PLoS One
- Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
- (2018) Michael M. Gaschler et al. ACS Chemical Biology
- CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer
- (2018) Eun Hye Kim et al. CANCER LETTERS
- Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
- (2018) Irina Ingold et al. CELL
- Regulation of lipid peroxidation and ferroptosis in diverse species
- (2018) Marcus Conrad et al. GENES & DEVELOPMENT
- Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
- (2018) Behrouz Hassannia et al. JOURNAL OF CLINICAL INVESTIGATION
- FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation
- (2018) Michael M. Gaschler et al. Nature Chemical Biology
- Understanding the tumor immune microenvironment (TIME) for effective therapy
- (2018) Mikhail Binnewies et al. NATURE MEDICINE
- The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
- (2018) Heike Miess et al. ONCOGENE
- Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
- (2018) Masaki Nagane et al. PLoS One
- Impact of l-Arginine Metabolism on Immune Response and Anticancer Immunotherapy
- (2018) Sun-Hee Kim et al. Frontiers in Oncology
- Role of Mitochondria in Ferroptosis
- (2018) Minghui Gao et al. MOLECULAR CELL
- Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition
- (2017) Matthew J. Hangauer et al. NATURE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- Metabolic Interactions in the Tumor Microenvironment
- (2017) Costas A. Lyssiotis et al. TRENDS IN CELL BIOLOGY
- Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis
- (2017) Z Fan et al. Oncogenesis
- Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
- (2017) Jong-Lyel Roh et al. Redox Biology
- The Roles of NRF2 in Modulating Cellular Iron Homeostasis
- (2017) Michael John Kerins et al. ANTIOXIDANTS & REDOX SIGNALING
- Autophagy promotes ferroptosis by degradation of ferritin
- (2016) Wen Hou et al. Autophagy
- Identification of ACSL4 as a biomarker and contributor of ferroptosis
- (2016) Hua Yuan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Human pluripotent stem cell culture density modulates YAP signaling
- (2016) Cheston Hsiao et al. Biotechnology Journal
- YAP/TAZ at the Roots of Cancer
- (2016) Francesca Zanconato et al. CANCER CELL
- Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer
- (2016) Jong-Lyel Roh et al. CANCER LETTERS
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- Ferroptosis is an autophagic cell death process
- (2016) Minghui Gao et al. CELL RESEARCH
- Mechanisms of ferroptosis
- (2016) Jennifer Yinuo Cao et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The host STING pathway at the interface of cancer and immunity
- (2016) Leticia Corrales et al. JOURNAL OF CLINICAL INVESTIGATION
- Arginine-Dual roles as an onconutrient and immunonutrient
- (2016) Vance L. Albaugh et al. JOURNAL OF SURGICAL ONCOLOGY
- Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
- (2016) Valerian E Kagan et al. Nature Chemical Biology
- ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
- (2016) Sebastian Doll et al. Nature Chemical Biology
- Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
- (2016) Kenichi Shimada et al. Nature Chemical Biology
- Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
- (2016) Shira L Cramer et al. NATURE MEDICINE
- Damage-associated molecular patterns in cancer: a double-edged sword
- (2016) C Hernandez et al. ONCOGENE
- Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
- (2016) Wan Seok Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human pluripotent stem cell culture density modulates YAP signaling
- (2016) Cheston Hsiao et al. Biotechnology Journal
- Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
- (2015) Scott J. Dixon et al. ACS Chemical Biology
- The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells
- (2015) Christophe Louandre et al. CANCER LETTERS
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
- (2015) Mai Matsushita et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ACaenorhabditis elegansmodel for ether lipid biosynthesis and function
- (2015) Xun Shi et al. JOURNAL OF LIPID RESEARCH
- Glutaminolysis and Transferrin Regulate Ferroptosis
- (2015) Minghui Gao et al. MOLECULAR CELL
- Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis
- (2015) Balaji Srinivasan et al. Nature Chemical Biology
- Behavioral characterization of system xc- mutant mice
- (2014) Elizabeth A. McCullagh et al. BEHAVIOURAL BRAIN RESEARCH
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
- (2014) Rachid Skouta et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
- (2014) Joseph D. Mancias et al. NATURE
- Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
- (2014) William E. Dowdle et al. NATURE CELL BIOLOGY
- Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
- (2014) Scott J Dixon et al. eLife
- Immunogenic Cell Death in Cancer Therapy
- (2012) Guido Kroemer et al. Annual Review of Immunology
- The innate immune response to products of phospholipid peroxidation
- (2012) David Weismann et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- Free Radical Lipid Peroxidation: Mechanisms and Analysis
- (2011) Huiyong Yin et al. CHEMICAL REVIEWS
- Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity
- (2011) Yury I. Miller et al. CIRCULATION RESEARCH
- Immunity, Inflammation, and Cancer
- (2010) Sergei I. Grivennikov et al. CELL
- Oxidative stress, inflammation, and cancer: How are they linked?
- (2010) Simone Reuter et al. FREE RADICAL BIOLOGY AND MEDICINE
- Autophagy: cellular and molecular mechanisms
- (2010) Danielle Glick et al. JOURNAL OF PATHOLOGY
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
- (2008) Wan Seok Yang et al. CHEMISTRY & BIOLOGY
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