Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

(2022) Dylan G. Ryan et al.   iScience

Liensinine alleviates high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) through suppressing oxidative stress and inflammation via regulating TAK1/AMPK signaling

(2022) Liping Liang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of the Retinoid receptor, RAR/RXR heterodimer, in liver physiology

(2021) Baixue Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?

(2021) Yana Geng et al.   Hepatology International

The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2

(2021) Chunjie Meng et al.   ONCOGENE

Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B

(2021) Latika Nagpal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress kinases in the development of liver steatosis and hepatocellular carcinoma

(2021) Beatriz Cicuéndez et al.   Molecular Metabolism

Roles of Ceramides in Non-Alcoholic Fatty Liver Disease

(2021) Eric Hajduch et al.   Journal of Clinical Medicine

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

(2021) Tian Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non-alcoholic fatty liver disease

(2021) Elizabeth E Powell et al.   LANCET

The Role of Fructose in Non-Alcoholic Steatohepatitis: Old Relationship and New Insights

(2021) Alessandro Federico et al.   Nutrients

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

(2021) Yuta Horie et al.   Communications Biology

Nuclear receptors in liver fibrosis

(2021) Philipp Königshofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Melatonin induces Nrf2‐HO‐1 reprogramming and corrections in hepatic core clock oscillations in Non‐alcoholic fatty liver disease

(2021) Apeksha Joshi et al.   FASEB JOURNAL

Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity.

(2021) Valerio Azzimato et al.   GASTROENTEROLOGY

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

(2021) Inês C. M. Simões et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fructose and the Liver

(2021) Pablo Muriel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis

(2021) Kazuhiko Igarashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in liver diseases: A review

(2021) Hui Qian et al.   MOLECULAR ASPECTS OF MEDICINE

Redox metabolism: ROS as specific molecular regulators of cell signaling and function

(2021) Claudia Lennicke et al.   MOLECULAR CELL

Changes in Key Mitochondrial Lipids Accompany Mitochondrial Dysfunction and Oxidative Stress in NAFLD

(2021) Manon Durand et al.   Oxidative Medicine and Cellular Longevity

Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism

(2021) Pengfei Liu et al.   Molecular Metabolism

Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules

(2021) Debajyoti Das et al.   Redox Biology

Cisd2 slows down liver aging and attenuates age‐related metabolic dysfunction in male mice

(2021) Yi‐Long Huang et al.   AGING CELL

Molecular aspects of fructose metabolism and metabolic disease

(2021) Mark A. Herman et al.   Cell Metabolism

Backstage players of fibrosis: NOX4, mTOR, HDAC, and S1P; companions of TGF-β

(2021) Alexis Paulina Jiménez-Uribe et al.   CELLULAR SIGNALLING

BTT‐105 ameliorates hepatic fibrosis in non‐alcoholic fatty liver animal model

(2021) Hye Young Kim et al.   FASEB JOURNAL

Macrophage nuclear factor erythroid 2‐related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3–mediated RhoA/ROCK pathway in the ischemic liver

(2021) Jianhua Rao et al.   HEPATOLOGY

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

(2021) Ying Wang et al.   NATURE

Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation

(2021) Juntao Yuan et al.   Redox Biology

Fructose and hepatic insulin resistance

(2020) Samir Softic et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

JNK Phosphorylates The Neh6 Domain Of Nrf2 And Downregulates Cytoprotective Genes In Acetaminophen‐Induced Liver Injury

(2020) Yiping Chen et al.   HEPATOLOGY

Endoplasmic reticulum-associated degradation and beyond: The multitasking roles for HRD1 in immune regulation and autoimmunity

(2020) Yuanming Xu et al.   JOURNAL OF AUTOIMMUNITY

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance

(2020) Valerio Azzimato et al.   Science Translational Medicine

Deconstructing the Role of PKC Epsilon in Glucose Homeostasis

(2020) Carsten Schmitz-Peiffer   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The NLRP3 inflammasome regulates adipose tissue metabolism

(2020) Nicole G. Barra et al.   BIOCHEMICAL JOURNAL

Genetic pathways in nonalcoholic fatty liver disease: Insights from systems biology

(2020) Silvia Sookoian et al.   HEPATOLOGY

Death by lipids: the role of small nucleolar RNAs in metabolic stress

(2020) Jean E. Schaffer   JOURNAL OF BIOLOGICAL CHEMISTRY

The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation

(2020) William P. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

(2020) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD

(2020) Shuoyi Ma et al.   LIVER INTERNATIONAL

Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production

(2020) Jia-Nan Wang et al.   Redox Biology

Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation

(2020) Meiyu Jin et al.   Oxidative Medicine and Cellular Longevity

Role of the ERO1-PDI interaction in oxidative protein folding and disease

(2020) Andrea G. Shergalis et al.   PHARMACOLOGY & THERAPEUTICS

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

(2020) Yi Lu et al.   Science Translational Medicine

Nonalcoholic Steatohepatitis Promoting Kinases

(2020) Samar H. Ibrahim et al.   SEMINARS IN LIVER DISEASE

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

(2020) Sharadha Dayalan Naidu et al.   Open Biology

Lipophagy Impairment Is Associated With Disease Progression in NAFLD

(2020) Simone Carotti et al.   Frontiers in Physiology

SQSTM1/p62 controls mtDNA expression and participates in mitochondrial energetic adaption via MRPL12

(2020) Yuan Ma et al.   iScience

Emerging crosstalk between long non-coding RNAs and Nrf2 signaling

(2020) Shamee Bhattacharjee et al.   CANCER LETTERS

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

(2020) Antje Mohs et al.   JOURNAL OF HEPATOLOGY

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

Mining a human transcriptome database for chemical modulators of NRF2

(2020) John P. Rooney et al.   PLoS One

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals

(2020) Shamee Bhattacharjee et al.   Antioxidants

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

(2020) Elena V. Knatko et al.   iScience

Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity

(2020) Luke J. Fulcher et al.   BIOCHEMICAL JOURNAL

Transcriptional factor ATF3 promotes liver fibrosis via activating hepatic stellate cells

(2020) Zhemin Shi et al.   Cell Death & Disease

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

(2020) Cheng Peng et al.   Frontiers in Pharmacology

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

(2020) Holly Robertson et al.   Cancers

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

(2020) Clémence Rives et al.   Biomolecules

Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD

(2020) Douglas G. Mashek   Molecular Metabolism

Role of aldehyde dehydrogenases in physiopathological processes

(2019) José Salud Rodríguez-Zavala et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The CHD6 chromatin remodeler is an oxidative DNA damage response factor

(2019) Shaun Moore et al.   Nature Communications

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

(2019) Ping Wang et al.   Nature Communications

Specificity, versatility, and control of TGF-β family signaling

(2019) Rik Derynck et al.   Science Signaling

DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer

(2019) Qi Zhang et al.   CELL DEATH AND DIFFERENTIATION

Peroxiredoxin 6 Confers Protection Against Nonalcoholic Fatty Liver Disease Through Maintaining Mitochondrial Function

(2019) Dong Hun Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK/Nrf2 pathway

(2019) Zijian Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

(2019) Gianluca Svegliati-Baroni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diagnosis and management of non-alcoholic fatty liver disease

(2019) Erica Jennison et al.   POSTGRADUATE MEDICAL JOURNAL

eNOS Deletion Impairs Mitochondrial Quality Control and Exacerbates Western Diet Induced NASH

(2019) Ryan D Sheldon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Polyphenol-Rich Loquat Fruit Extract Prevents Fructose-Induced Nonalcoholic Fatty Liver Disease by Modulating Glycometabolism, Lipometabolism, Oxidative Stress, Inflammation, Intestinal Barrier, and Gut Microbiota in Mice

(2019) Wenfeng Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Phosphorylation of USP15 and USP4 Regulates Localization and Spliceosomal Deubiquitination

(2019) Tanuza Das et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1

(2019) Takafumi Suzuki et al.   Cell Reports

Hepatic IRF2BP2 Mitigates Nonalcoholic Fatty Liver Disease by Directly Repressing the Transcription of ATF3

(2019) Jing Fang et al.   HEPATOLOGY

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

(2019) Micah B. Schott et al.   JOURNAL OF CELL BIOLOGY

Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells

(2019) Fumiki Katsuoka et al.   MOLECULAR AND CELLULAR BIOLOGY

Upregulation of CKIP-1 inhibits high-glucose induced inflammation and oxidative stress in HRECs and attenuates diabetic retinopathy by modulating Nrf2/ARE signaling pathway: an in vitro study

(2019) Lan Zhang et al.   Cell and Bioscience

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

(2019) Rajarshi Ghosh et al.   Molecular Metabolism

Nrf2 in liver toxicology

(2019) Keiko Taguchi et al.   ARCHIVES OF PHARMACAL RESEARCH

Adaptive immunity: an emerging player in the progression of NAFLD

(2019) Salvatore Sutti et al.   Nature Reviews Gastroenterology & Hepatology

Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and mitochondrial function

(2019) Kapil K. Upadhyay et al.   Redox Biology

A partnership with the proteasome; the destructive nature of GSK3

(2018) Holly Robertson et al.   BIOCHEMICAL PHARMACOLOGY

Animal models of NAFLD from a hepatologist's point of view

(2018) Daniel Jahn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice

(2018) Shasha Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The assembly of lipid droplets and their roles in challenged cells

(2018) W Mike Henne et al.   EMBO JOURNAL

Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis

(2018) Kentaro Akiyama et al.   EXPERIMENTAL ANIMALS

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

Fructose metabolism and metabolic disease

(2018) Sarah A. Hannou et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic Reticulum stress signaling and the pathogenesis of Non-Alcoholic Fatty Liver Disease

(2018) Cynthia Lebeaupin et al.   JOURNAL OF HEPATOLOGY

Preclinical models of non-alcoholic fatty liver disease

(2018) Prasanna K. Santhekadur et al.   JOURNAL OF HEPATOLOGY

Fructose and sugar: A major mediator of non-alcoholic fatty liver disease

(2018) Thomas Jensen et al.   JOURNAL OF HEPATOLOGY

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Triggering and resolution of inflammation in NASH

(2018) Susanne Schuster et al.   Nature Reviews Gastroenterology & Hepatology

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression

(2018) Francesco Bellanti et al.   Redox Biology

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

Antioxidant response elements: Discovery, classes, regulation and potential applications

(2018) Azhwar Raghunath et al.   Redox Biology

Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer

(2018) Nikos Koundouros et al.   Frontiers in Oncology

NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice

(2018) Jing Sun et al.   FOOD AND CHEMICAL TOXICOLOGY

Black Sesame Seeds Ethanol Extract Ameliorates Hepatic Lipid Accumulation, Oxidative Stress and Insulin Resistance in Fructose-induced Nonalcoholic Fatty Liver Disease

(2018) Yang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

(2018) John Rooney et al.   PLoS One

Lipid mediators of liver injury in nonalcoholic fatty liver disease

(2018) Suthat Liangpunsakul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular pathways of nonalcoholic fatty liver disease development and progression

(2018) Fernando Bessone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Downregulated microRNA-27b attenuates lipopolysaccharide-induced acute lung injury via activation of NF-E2-related factor 2 and inhibition of nuclear factor κB signaling pathway

(2018) Yan Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise

(2018) Matthew Hancock et al.   eLife

Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor

(2017) Sun-O Ka et al.   FASEB JOURNAL

The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2

(2017) Yulong Li et al.   FEBS LETTERS

The role of nonbilayer phospholipids in mitochondrial structure and function

(2017) Writoban Basu Ball et al.   FEBS LETTERS

Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis

(2017) Francesco Bellanti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physiological/pathological ramifications of transcription factors in the unfolded protein response

(2017) Jaeseok Han et al.   GENES & DEVELOPMENT

Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice

(2017) Clara Jana-Lui Busch et al.   HEPATOLOGY

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

(2017) Md. Morshedul Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

(2017) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

IRS posttranslational modifications in regulating insulin signaling

(2017) Jinghua Peng et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver

(2017) Debora Nigro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease

(2017) Zhonge Chen et al.   Lipids in Health and Disease

Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions

(2017) John D. Hayes et al.   MOLECULAR CELL

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

(2017) Janin Henkel et al.   MOLECULAR MEDICINE

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide

(2017) Mikhaïl Van Herck et al.   Nutrients

microRNA-455 targets cullin 3 to activate Nrf2 signaling and protect human osteoblasts from hydrogen peroxide

(2017) Dawei Xu et al.   Oncotarget

WDR23 regulates NRF2 independently of KEAP1

(2017) Jacqueline Y. Lo et al.   PLoS Genetics

Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole

(2017) Takuma Tsuji et al.   eLife

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

(2016) Susmita Kaushik et al.   Autophagy

High glucose induces the expression of osteopontin in blood vessels in vitro and in vivo

(2016) Tianjia Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repression of the Antioxidant NRF2 Pathway in Premature Aging

(2016) Nard Kubben et al.   CELL

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

(2016) Samir Softic et al.   DIGESTIVE DISEASES AND SCIENCES

TGF-β signalling and liver disease

(2016) Isabel Fabregat et al.   FEBS Journal

Cysteine residues mediate high-affinity binding of thioredoxin to ASK1

(2016) Salome Kylarova et al.   FEBS Journal

NF-E2-related factor 2 deletion facilitates hepatic fatty acids metabolism disorder induced by high-fat diet via regulating related genes in mice

(2016) Xinghe Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

(2016) Da Hyun Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development

(2016) Pierluigi Ramadori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contribution of Alcoholic and Nonalcoholic Fatty Liver Disease to the Burden of Liver-Related Morbidity and Mortality

(2016) Zobair Younossi et al.   GASTROENTEROLOGY

Regulation of Liver Metabolism by Autophagy

(2016) Julio Madrigal-Matute et al.   GASTROENTEROLOGY

Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Ppargpathway in adipogenesis

(2016) Mitsuyo Matsumoto et al.   GENES TO CELLS

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice

(2016) Troy L. Merry et al.   JOURNAL OF PHYSIOLOGY-LONDON

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

(2016) Akira Uruno et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet

(2016) Zhenxiong Liu et al.   Molecular Medicine Reports

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease

(2016) Carrie R Wong et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet

(2016) Shu-Fang Xia et al.   Nutrients

DNA Demethylation Upregulated Nrf2 Expression in Alzheimer’s Disease Cellular Model

(2016) Huimin Cao et al.   Frontiers in Aging Neuroscience

Drug-induced fatty liver disease: An overview of pathogenesis and management

(2015) Sanjaya Satapathy et al.   Annals of Hepatology

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MiR-141 Activates Nrf2-Dependent Antioxidant Pathway via Down-Regulating the Expression of Keap1 Conferring the Resistance of Hepatocellular Carcinoma Cells to 5-Fluorouracil

(2015) Liang Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα

(2015) Jin Sil Choi et al.   CELLULAR SIGNALLING

Lipid-dependent regulation of the unfolded protein response

(2015) Romain Volmer et al.   CURRENT OPINION IN CELL BIOLOGY

Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame

(2015) Samar H. Ibrahim et al.   DIGESTIVE DISEASES AND SCIENCES

Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin

(2015) Naravat Poungvarin et al.   ENDOCRINOLOGY

MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression

(2015) Savan Kabaria et al.   FREE RADICAL BIOLOGY AND MEDICINE

The antioxidant machinery of the endoplasmic reticulum: Protection and signaling

(2015) Agnès Delaunay-Moisan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative protein folding: From thiol–disulfide exchange reactions to the redox poise of the endoplasmic reticulum

(2015) Devin A. Hudson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis

(2015) Maki Goto et al.   GENES TO CELLS

Hepatic lipid droplet biology: Getting to the root of fatty liver

(2015) Douglas G. Mashek et al.   HEPATOLOGY

Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis

(2015) Chao Wang et al.   HEPATOLOGY

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction

(2015) Hélène C. Bertrand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis

(2015) Jamie E. Mells et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression

(2015) Hiroki Sekine et al.   MOLECULAR AND CELLULAR BIOLOGY

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Inflammasome activation and function in liver disease

(2015) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1

(2015) Chu-Sook Kim et al.   Nutrition & Metabolism

Transforming Growth Factor-Beta and Oxidative Stress Interplay: Implications in Tumorigenesis and Cancer Progression

(2015) Jelena Krstić et al.   Oxidative Medicine and Cellular Longevity

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Identification and Characterization of PERK Activators by Phenotypic Screening and Their Effects on NRF2 Activation

(2015) Wensheng Xie et al.   PLoS One

Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

(2015) Mariana Verdelho Machado et al.   PLoS One

Development of Hepatocellular Carcinoma in a Murine Model of Nonalcoholic Steatohepatitis Induced by Use of a High-Fat/Fructose Diet and Sedentary Lifestyle

(2014) Joanna K. Dowman et al.   AMERICAN JOURNAL OF PATHOLOGY

The PTEN/NRF2 Axis Promotes Human Carcinogenesis

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha

(2014) Jiaguo Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Monitoring Keap1–Nrf2 interactions in single live cells

(2014) Liam Baird et al.   BIOTECHNOLOGY ADVANCES

Treatment with baicalein attenuates methionine−choline deficient diet-induced non-alcoholic steatohepatitis in rats

(2014) Hai-Guang Xin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Role of Nrf2 in the alteration of cholesterol and bile acid metabolism-related gene expression by dietary cholesterol in high fat-fed mice

(2014) Toshinori Kamisako et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

TAK1 regulates hepatic cell survival and carcinogenesis

(2014) Yoon Seok Roh et al.   JOURNAL OF GASTROENTEROLOGY

Lipopolysaccharide-Induced Expression of NAD(P)H:Quinone Oxidoreductase 1 and Heme Oxygenase-1 Protects against Excessive Inflammatory Responses in Human Monocytes

(2014) S. A. Rushworth et al.   JOURNAL OF IMMUNOLOGY

Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes

(2014) Yea-Jin Choi et al.   LABORATORY INVESTIGATION

Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis

(2014) Roger Williams et al.   LANCET

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

(2014) Zoon Tariq et al.   LIVER INTERNATIONAL

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics

(2014) Azman Abdullah et al.   Pharmacological Reports

Inhibitory Role of the KEAP1-NRF2 Pathway in TGFβ1-Stimulated Renal Epithelial Transition to Fibroblastic Cells: A Modulatory Effect on SMAD Signaling

(2014) In-geun Ryoo et al.   PLoS One

HDAC Inhibitors Increase NRF2-Signaling in Tumour Cells and Blunt the Efficacy of Co-Adminstered Cytotoxic Agents

(2014) Michael McMahon et al.   PLoS One

Activation of the Nrf2-ARE Pathway in Hepatocytes Protects Against Steatosis in Nutritionally Induced Non-alcoholic Steatohepatitis in Mice

(2014) Lung-Yi Lee et al.   TOXICOLOGICAL SCIENCES

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity

(2014) Conor J Howard et al.   eLife

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

(2014) Uwe Knippschild et al.   Frontiers in Oncology

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

(2013) Jason R. Clapper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Does Hepatic Oxidative Stress Enhance Activation of Nuclear Factor-E2-Related Factor in Patients with Nonalcoholic Steatohepatitis?

(2013) Yurimi Takahashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

The role of oxidative stress during inflammatory processes

(2013) Jérôme Lugrin et al.   BIOLOGICAL CHEMISTRY

Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

(2013) Wei Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis

(2013) B. Singh et al.   CARCINOGENESIS

Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation

(2013) He-Fang Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding

(2013) Vijay R. More et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

(2013) Pooja Jha et al.   HEPATOLOGY

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

(2013) Melanie Theodore Malloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming Growth Factor-β Induces Transcription Factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene

(2013) Yukari Okita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death

(2013) Sandro Silva-Gomes et al.   JOURNAL OF HEPATOLOGY

Early Metabolic Adaptation in C57BL/6 Mice Resistant to High Fat Diet Induced Weight Gain Involves an Activation of Mitochondrial Oxidative Pathways

(2013) Claire L. Boulangé et al.   JOURNAL OF PROTEOME RESEARCH

A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma

(2013) Masato Fujii et al.   Medical Molecular Morphology

Hrd1 participates in the regulation of collagen I synthesis in renal fibrosis

(2013) Lei Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae

(2013) Tim van Zutphen et al.   MOLECULAR BIOLOGY OF THE CELL

USP15 Negatively Regulates Nrf2 through Deubiquitination of Keap1

(2013) Nicole F. Villeneuve et al.   MOLECULAR CELL

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Hepatic Gene Expression Profiling in Nrf2 Knockout Mice after Long-Term High-Fat Diet-Induced Obesity

(2013) Dionysios V. Chartoumpekis et al.   Oxidative Medicine and Cellular Longevity

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner

(2013) Kari T. Chambers et al.   Molecular Metabolism

Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation

(2013) Yizhe Cui et al.   Redox Biology

Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine

(2012) Jittima Weerachayaphorn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

The Gasotransmitter Hydrogen Sulfide Induces Nrf2-Target Genes by Inactivating the Keap1 Ubiquitin Ligase Substrate Adaptor Through Formation of a Disulfide Bond Between Cys-226 and Cys-613

(2012) John M. Hourihan et al.   ANTIOXIDANTS & REDOX SIGNALING

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Mitochondrial SKN-1/Nrf Mediates a Conserved Starvation Response

(2012) Jennifer Paek et al.   Cell Metabolism

Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice

(2012) Janhavi Athale et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia

(2012) Ariel D. Quiroga et al.   HEPATOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Transcriptional Network Analysis Identifies BACH1 as a Master Regulator of Breast Cancer Bone Metastasis

(2012) Yajun Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

(2012) Miguel A. Lanaspa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

(2012) Rohit Anthony Sinha et al.   JOURNAL OF CLINICAL INVESTIGATION

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis

(2012) Kosuke Okada et al.   JOURNAL OF GASTROENTEROLOGY

Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet

(2012) Kosuke Okada et al.   JOURNAL OF GASTROENTEROLOGY

Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice

(2012) Yuji Tanaka et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice

(2012) Kengo Tomita et al.   JOURNAL OF HEPATOLOGY

Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

(2012) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation

(2012) Ying Huang et al.   JOURNAL OF NUTRITION

Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats

(2012) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis1–3

(2012) Eder Marcolin et al.   JOURNAL OF NUTRITION

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

(2012) B. N. Chorley et al.   NUCLEIC ACIDS RESEARCH

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

(2012) Yosuke Hirotsu et al.   NUCLEIC ACIDS RESEARCH

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

(2012) J-H Kim et al.   ONCOGENE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Liver-Specific Expression of Transcriptionally Active SREBP-1c Is Associated with Fatty Liver and Increased Visceral Fat Mass

(2012) Birgit Knebel et al.   PLoS One

Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells

(2012) Madhusudhanan Narasimhan et al.   PLoS One

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

(2012) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation

(2012) Kai Connie Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genetically modified mouse models for the study of nonalcoholic fatty liver disease

(2012) Perumal Nagarajan   WORLD JOURNAL OF GASTROENTEROLOGY

Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2012) Yoshihisa Takahashi   WORLD JOURNAL OF GASTROENTEROLOGY

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

(2011) Michael Charlton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

(2011) Keisuke Kakisaka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

(2011) Nicolas Mercado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism

(2011) Muhua Yang et al.   BREAST CANCER RESEARCH AND TREATMENT

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

(2011) Abena S. Agyeman et al.   BREAST CANCER RESEARCH AND TREATMENT

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Insulin signaling to hepatic lipid metabolism in health and disease

(2011) Karla F. Leavens et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

Nrf2 Represses FGF21 During Long-Term High-Fat Diet-Induced Obesity in Mice

(2011) D. V. Chartoumpekis et al.   DIABETES

Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis

(2011) Jiang Wei Wu et al.   HEPATOLOGY

Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization

(2011) Yumiko Kawai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Oxidation of Hepatic Carnitine Palmitoyl Transferase-I (CPT-I) Impairs Fatty Acid Beta-Oxidation in Rats Fed a Methionine-Choline Deficient Diet

(2011) Gaetano Serviddio et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Detoxification: A Novel Function of BRCA1 in Tumor Suppression?

(2011) Hyo Jin Kang et al.   TOXICOLOGICAL SCIENCES

Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption

(2011) Kai Connie Wu et al.   TOXICOLOGICAL SCIENCES

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

(2010) C. Sangokoya et al.   BLOOD

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes

(2010) Michael L. Wang et al.   Cell Metabolism

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Epidemiology of Non-Alcoholic Fatty Liver Disease

(2010) Stefano Bellentani et al.   DIGESTIVE DISEASES

Diversity in Antioxidant Response Enzymes in Progressive Stages of Human Nonalcoholic Fatty Liver Disease

(2010) R. N. Hardwick et al.   DRUG METABOLISM AND DISPOSITION

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis

(2010) Rohit Kohli et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2

(2010) Kendra S. Plafker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of NRF2 by Nitrosative Agents and H2O2Involves KEAP1 Disulfide Formation

(2010) Simon Fourquet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidants Positively or Negatively Regulate Nuclear Factor κB in a Context-dependent Manner

(2010) Noureddine Loukili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model

(2010) Motoki Inoue et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in High Carbohydrate–, High Fat–Fed Rats

(2010) Hemant Poudyal et al.   JOURNAL OF NUTRITION

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

(2010) Neil R. Kitteringham et al.   Journal of Proteomics

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

(2010) K. Taguchi et al.   MOLECULAR AND CELLULAR BIOLOGY

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

(2010) Jung Sub Lim et al.   Nature Reviews Gastroenterology & Hepatology

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Increased cell migration and plasticity in Nrf2-deficient cancer cell lines

(2010) G Rachakonda et al.   ONCOGENE

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet☆

(2010) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reactive oxygen species and insulin resistance: the good, the bad and the ugly

(2010) Tony Tiganis   TRENDS IN PHARMACOLOGICAL SCIENCES

Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation

(2009) Rajat Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

(2009) Hirokazu Sugimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Deletion ofKeap1in the Lung Attenuates Acute Cigarette Smoke–Induced Oxidative Stress and Inflammation

(2009) David J. Blake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach

(2009) Johannes Witt et al.   BMC Systems Biology

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

(2009) A.Kenneth MacLeod et al.   CARCINOGENESIS

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

(2009) R.-M. Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development

(2009) M. R. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent

(2008) Laura H. Tetri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2 Related Factor 2 (Nrf2) Regulated Stress Pathway

(2008) S. L. Brown et al.   CANCER RESEARCH

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Nuclear Factor-Eythroid 2–Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury

(2008) Jutta Lamlé et al.   GASTROENTEROLOGY

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

(2008) Melanie Theodore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A simple method for amino acid selective isotope labeling of recombinant proteins in E. coli

(2008) Kit I. Tong et al.   JOURNAL OF BIOMOLECULAR NMR

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Genome-Wide Occupancy of SREBP1 and Its Partners NFY and SP1 Reveals Novel Functional Roles and Combinatorial Regulation of Distinct Classes of Genes

(2008) Brian D. Reed et al.   PLoS Genetics