The NLRP3 inflammasome regulates adipose tissue metabolism

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Regulation of adipose tissue inflammation by interleukin 6

(2020) Myoung Sook Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance

(2019) Sarah M. Turpin-Nolan et al.   Cell Reports

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Statins Promote IL-1β-Dependent Adipocyte Insulin Resistance via Lower Prenylation not Cholesterol

(2019) Brandyn D. Henriksbo et al.   DIABETES

Prospective analyses of white adipose tissue gene expression in relation to long-term body weight changes

(2019) Kelvin H. M. Kwok et al.   INTERNATIONAL JOURNAL OF OBESITY

Adipose tissue browning in mice and humans

(2019) Carsten T Herz et al.   JOURNAL OF ENDOCRINOLOGY

NLRP3 Inflammasome Mediates White Adipose Tissue Browning After Burn

(2019) Roohi Vinaik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

(2019) Xabier Unamuno et al.   Cellular & Molecular Immunology

Glucose alters the symbiotic relationships between gut microbiota and host physiology

(2019) Fernando F. Anhê et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

(2019) Christina D. Camell et al.   Cell Metabolism

Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway

(2018) Xiao Zhu et al.   ACTA PHARMACOLOGICA SINICA

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

(2018) Graeme I. Lancaster et al.   Cell Metabolism

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation

(2018) Petra Kotzbeck et al.   JOURNAL OF LIPID RESEARCH

A primer on caspase mechanisms

(2018) Monica L. Gonzalez Ramirez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

(2018) Song-Yang Zhang et al.   EBioMedicine

Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program

(2018) George A Bray et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

(2018) Nigel Turner et al.   Nature Communications

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

(2018) Mercedes Monteleone et al.   Cell Reports

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Nod1-mediated lipolysis promotes diacylglycerol accumulation and successive inflammation via PKCδ-IRAK axis in adipocytes

(2018) Aditya Sharma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

(2018) Congfei Xu et al.   Nature Communications

circARF3 Alleviates Mitophagy-Mediated Inflammation by Targeting miR-103/TRAF3 in Mouse Adipose Tissue

(2018) Zhenzhen Zhang et al.   Molecular Therapy-Nucleic Acids

Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium

(2017) Xiaoshan Xu et al.   EUROPEAN JOURNAL OF NUTRITION

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

(2017) Jin Kyung Kim et al.   IMMUNOLOGY AND CELL BIOLOGY

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning

(2017) Meshail Okla et al.   INFLAMMATION

Molecular mechanisms of inflammasome signaling

(2017) Anukriti Mathur et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tauroursodeoxycholic acid inhibits TNF-α-induced lipolysis in 3T3-L1 adipocytes via the IRE-JNK-perilipin-A signaling pathway

(2017) Wenyan Xia et al.   Molecular Medicine Reports

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

(2017) Christina D. Camell et al.   NATURE

Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia

(2017) Brittany M. Duggan et al.   Scientific Reports

Alendronate treatment induces IL-1B expression and apoptosis in glioblastoma cell line

(2017) Paola Maura Tricarico et al.   INFLAMMOPHARMACOLOGY

Toll-Like Receptors in Endocrine Disease and Diabetes

(2017) W. Kanczkowski et al.   NEUROIMMUNOMODULATION

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

(2016) Jennifer H. Stern et al.   Cell Metabolism

Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans

(2016) Bryan C. Bergman et al.   DIABETOLOGIA

Bisphosphonates: Pharmacokinetics, bioavailability, mechanisms of action, clinical applications in children, and effects on tooth development

(2016) Ana Prates Soares et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Association of Changes in Abdominal Fat Quantity and Quality With Incident Cardiovascular Disease Risk Factors

(2016) Jane J. Lee et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Control of brown and beige fat development

(2016) Wenshan Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model

(2016) Jun Zha et al.   PLoS One

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

(2016) Laura E Sanman et al.   eLife

Immunometabolism of obesity and diabetes: microbiota link compartmentalized immunity in the gut to metabolic tissue inflammation

(2015) J. B. McPhee et al.   CLINICAL SCIENCE

Mechanisms of unconventional secretion of IL-1 family cytokines

(2015) Mercedes Monteleone et al.   CYTOKINE

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance

(2015) E. Denou et al.   EMBO Molecular Medicine

Macrophage-specificde NovoSynthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity

(2015) Christina D. Camell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Iron primes 3T3-L1 adipocytes to a TLR4-mediated inflammatory response

(2015) Salvatore Chirumbolo et al.   NUTRITION

Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats

(2015) Andreea Oana Mocanu et al.   PLoS One

Is immunity a mechanism contributing to statin-induced diabetes?

(2015) Brandyn D Henriksbo et al.   Adipocyte

Adipose tissue and its role in organ crosstalk

(2014) T. Romacho et al.   Acta Physiologica

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Adipocyte Inflammation Is Essential for Healthy Adipose Tissue Expansion and Remodeling

(2014) Ingrid Wernstedt Asterholm et al.   Cell Metabolism

Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance

(2014) Brandyn D. Henriksbo et al.   DIABETES

The Use of Bisphosphonates in Pediatrics

(2014) Giampiero I. Baroncelli et al.   Hormone Research in Paediatrics

3-Hydroxyl-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor (Statin)-induced 28-kDa Interleukin-1β Interferes with Mature IL-1β Signaling

(2014) Facundo Davaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomes Integrate Metabolic-Inflammatory Cross-talk in Primary Macrophage Inflammasome Activation

(2014) Kassandra Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

Bacterial Peptidoglycan Stimulates Adipocyte Lipolysis via NOD1

(2014) Wendy Chi et al.   PLoS One

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice

(2013) Birgitte Lindegaard et al.   DIABETES

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Innate sensors of pathogen and stress: Linking inflammation to obesity

(2013) Chengcheng Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis

(2013) Antonio Giordano et al.   JOURNAL OF LIPID RESEARCH

Plasma lipid profiling in a large population-based cohort

(2013) Jacquelyn M. Weir et al.   JOURNAL OF LIPID RESEARCH

Precision of a new tool to measure visceral adipose tissue (VAT) using dual-energy X-Ray absorptiometry (DXA)

(2013) Megan P. Rothney et al.   Obesity

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

(2013) Amandine Girousse et al.   PLOS BIOLOGY

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Change in Visceral Adiposity Independently Predicts a Greater Risk of Developing Type 2 Diabetes Over 10 Years in Japanese Americans

(2012) P. L. Wander et al.   DIABETES CARE

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein

(2012) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Maturation Arrest: A Determinant of Systemic Insulin Resistance to Glucose Disposal

(2012) Nicola Abate   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The relationship between the chemistry and biological activity of the bisphosphonates

(2011) Frank H. Ebetino et al.   BONE

Pharmacology of bisphosphonates

(2011) Serge Cremers et al.   BONE

Perivascular adipose tissue and vascular disease

(2011) Kathryn A Britton et al.   Clinical Lipidology

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

(2011) Yun-Hee Youm et al.   ENDOCRINOLOGY

Identification and Validation of Novel Adipokines Released from Primary Human Adipocytes

(2011) Stefan Lehr et al.   MOLECULAR & CELLULAR PROTEOMICS

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Cryopyrin-Associated Periodic Syndrome: An Update on Diagnosis and Treatment Response

(2010) Justin R. Yu et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Interleukin-1β induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: Involvement of ERK, JNK, AP-1, and NF-κB

(2010) Chuen-Mao Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Caspase-1 recognizes extended cleavage sites in its natural substrates

(2009) Jerry Shen et al.   ATHEROSCLEROSIS

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The major inflammatory mediator interleukin-6 and obesity

(2009) Katalin Eder et al.   INFLAMMATION RESEARCH

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

(2009) L. O'Regan et al.   MOLECULAR AND CELLULAR BIOLOGY

Lipolysis and lipid mobilization in human adipose tissue

(2009) Max Lafontan et al.   PROGRESS IN LIPID RESEARCH

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

(2008) O. Osborn et al.   CYTOKINE

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION