Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals

Health benefits of fucoxanthin in the prevention of chronic diseases

(2020) Minkyung Bae et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress

(2020) Milad Ashrafizadeh et al.   LIFE SCIENCES

Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols

(2020) Chung S. Yang et al.   MOLECULAR CARCINOGENESIS

MicroRNAs as novel targets of sulforaphane in cancer therapy: The beginning of a new tale?

(2020) Hossein Rafiei et al.   PHYTOTHERAPY RESEARCH

Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway

(2020) Youming Chen et al.   Aging-US

3,3-Diindolylmethane (DIM): A nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial

(2020) Rinat Yerushalmi et al.   CARCINOGENESIS

Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury

(2020) Tian-Xin Zhao et al.   ENVIRONMENTAL POLLUTION

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer

(2020) Jong-Su Kang et al.   BIOCHEMICAL PHARMACOLOGY

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation

(2020) Meiling Gong et al.   Cell Communication and Signaling

Emerging crosstalk between long non-coding RNAs and Nrf2 signaling

(2020) Shamee Bhattacharjee et al.   CANCER LETTERS

Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition

(2019) Praveen Rajendran et al.   CANCER RESEARCH

Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer

(2019) Helai P. Mohammad et al.   NATURE MEDICINE

Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer

(2019) Linbo Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Z-Ligustilide protects vascular endothelial cells from oxidative stress and rescues high fat diet-induced atherosclerosis by activating multiple NRF2 downstream genes

(2019) Yao Zhu et al.   ATHEROSCLEROSIS

Luteolin, a flavonoid, as an anticancer agent: A review

(2019) Muhammad Imran et al.   BIOMEDICINE & PHARMACOTHERAPY

Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells

(2019) Kyoung Ah Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Nrf2 in cancers: A double‐edged sword

(2019) Shijia Wu et al.   Cancer Medicine

Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway

(2019) Hsiao-Chen Dina Kuo et al.   AAPS Journal

Pelargonidin reduces the TPA induced transformation of mouse epidermal cells –potential involvement of Nrf2 promoter demethylation

(2019) Shanyi Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2

(2019) Yujie Yang et al.   LIVER INTERNATIONAL

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

(2019) Yoko Yagishita et al.   MOLECULES

Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

(2019) Christine A. Houghton   Oxidative Medicine and Cellular Longevity

Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1

(2019) Jesse R. Poganik et al.   FASEB JOURNAL

Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway

(2019) Hossein Hosseini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The timeline of epigenetic drug discovery: from reality to dreams

(2019) A. Ganesan et al.   Clinical Epigenetics

Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells

(2018) Yuqing Yang et al.   AAPS Journal

BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors

(2018) Nirmalya Chatterjee et al.   BIOESSAYS

Apigenin: A dietary flavonoid with diverse anticancer properties

(2018) Josip Madunić et al.   CANCER LETTERS

Vitamin E and its anticancer effects

(2018) Annette Abraham et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

MiR-455-3p activates Nrf2/ARE signaling via HDAC2 and protects osteoblasts from oxidative stress

(2018) Shijun Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells

(2018) Linbo Gao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells

(2018) Jie Yang et al.   MOLECULAR CARCINOGENESIS

Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells

(2018) Chao Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs

(2018) F. P. Fabrizio et al.   Oxidative Medicine and Cellular Longevity

Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway

(2018) Xuling Su et al.   Oxidative Medicine and Cellular Longevity

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway

(2018) Xiao-Juan Zhao et al.   Redox Biology

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells

(2018) Qian Zuo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets

(2018) Marina Montagnani Marelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diet and the epigenome

(2018) Yi Zhang et al.   Nature Communications

Sabotaging of the oxidative stress response by an oncogenic noncoding RNA

(2017) Nitin Mahajan et al.   FASEB JOURNAL

Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications

(2017) Haixue Kuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer

(2017) Laura M. Beaver et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1

(2017) Burak Akdemir et al.   MOLECULAR CANCER RESEARCH

A functional pseudogene,NMRAL2P, is regulated by Nrf2 and serves as a coactivator ofNQO1in sulforaphane-treated colon cancer cells

(2017) Gavin S. Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

(2017) Chengyue Zhang et al.   MOLECULAR PHARMACEUTICS

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats

(2017) David Brocks et al.   NATURE GENETICS

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway

(2017) Ai-Mei Gao et al.   Oncotarget

Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma

(2017) Federico Pio Fabrizio et al.   Oncotarget

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway

(2016) Bo Hong et al.   AAPS Journal

MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer

(2016) B. Zhang et al.   CURRENT MOLECULAR MEDICINE

Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1expression

(2016) Tsui-Hwa Tseng et al.   ENVIRONMENTAL TOXICOLOGY

Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells

(2016) Hyuck Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The bounty of nature for changing the cancer landscape

(2016) Aamir Ahmad et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg

(2016) Naomi Fujioka et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

(2016) Leonard D. Goldstein et al.   Cell Reports

Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

(2015) Bryan Harder et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

NRF2 and microRNAs: new but awaited relations

(2015) Svitlana Kurinna et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Taxifolin curbs NF-κB-mediated Wnt/β-catenin signaling via up-regulating Nrf2 pathway in experimental colon carcinogenesis

(2015) Krishnan Manigandan et al.   BIOCHIMIE

Z-ligustilide ameliorated ultraviolet B-induced oxidative stress and inflammatory cytokine production in human keratinocytes through upregulation of Nrf2/HO-1 and suppression of NF-κB pathway

(2015) Zhouwei Wu et al.   EXPERIMENTAL DERMATOLOGY

MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression

(2015) Savan Kabaria et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic regulation of Keap1-Nrf2 signaling

(2015) Yue Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells

(2015) Kaipeng Huang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components

(2015) Christina DiMarco-Crook et al.   Annual Review of Food Science and Technology

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

(2015) Praveen Rajendran et al.   Clinical Epigenetics

Blocking of JB6 Cell Transformation by Tanshinone IIA: Epigenetic Reactivation of Nrf2 Antioxidative Stress Pathway

(2014) Ling Wang et al.   AAPS Journal

Apigenin Reactivates Nrf2 Anti-oxidative Stress Signaling in Mouse Skin Epidermal JB6 P + Cells Through Epigenetics Modifications

(2014) Ximena Paredes-Gonzalez et al.   AAPS Journal

Epigenetic DNA Methylation of Antioxidative Stress Regulator NRF2 in Human Prostate Cancer

(2014) T. O. Khor et al.   Cancer Prevention Research

Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways

(2014) Bhupendra Singh et al.   CARCINOGENESIS

The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2

(2014) Ziming Li et al.   FEBS LETTERS

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

(2014) Carmen P. Wong et al.   PLoS One

The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response

(2014) M Hussong et al.   Cell Death & Disease

Dietary Regulation of Keap1/Nrf2/ARE Pathway: Focus on Plant-Derived Compounds and Trace Minerals

(2014) Amanda Stefanson et al.   Nutrients

Epigenetic Modifications of Nrf2 by 3,3′-diindolylmethane In Vitro in TRAMP C1 Cell Line and In Vivo TRAMP Prostate Tumors

(2013) Tien-Yuan Wu et al.   AAPS Journal

Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia–reperfusion injury in vivo and in vitro

(2013) Bin Peng et al.   BRAIN RESEARCH

Epigenetic Reactivation of Nrf2 in Murine Prostate Cancer TRAMP C1 Cells by Natural Phytochemicals Z-Ligustilide and Radix Angelica Sinensis via Promoter CpG Demethylation

(2013) Zheng-Yuan Su et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Epigenetic impact of dietary isothiocyanates in cancer chemoprevention

(2013) Clarissa Gerhauser   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Notch-Nrf2 Axis: Regulation of Nrf2 Gene Expression and Cytoprotection by Notch Signaling

(2013) N. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: Maternal diets rich in indole-3-carbinol versus sulforaphane

(2013) Lyndsey E. Shorey et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells

(2012) Duo Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

AberrantKeap1methylation in breast cancer and association with clinicopathological features

(2012) Raffaela Barbano et al.   Epigenetics

A γ-Tocopherol-Rich Mixture of Tocopherols Maintains Nrf2 Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation

(2012) Ying Huang et al.   JOURNAL OF NUTRITION

miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells

(2012) M T M van Jaarsveld et al.   ONCOGENE

3,3′-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells

(2012) Laura M. Beaver et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dietary Factors and Epigenetic Regulation for Prostate Cancer Prevention

(2012) Emily Ho et al.   Advances in Nutrition

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

(2011) Nicolas Mercado et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

(2011) Tin Oo Khor et al.   BIOCHEMICAL PHARMACOLOGY

Regulation ofKEAP1expression by promoter methylation in malignant gliomas and association with patient’s outcome

(2011) Lucia Anna Muscarella et al.   Epigenetics

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer

(2011) Lucia Anna Muscarella et al.   Epigenetics

miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: In vitro and in vivo study

(2011) Mitali Pandey et al.   MOLECULAR CARCINOGENESIS

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells

(2011) Anna Hsu et al.   Clinical Epigenetics

Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features

(2010) L. M. Solis et al.   CLINICAL CANCER RESEARCH

Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice

(2010) Siwang Yu et al.   PLoS One

Cancer-preventive activities of tocopherols and tocotrienols

(2009) Jihyeung Ju et al.   CARCINOGENESIS

Nrf2: friend or foe for chemoprevention?

(2009) T. W. Kensler et al.   CARCINOGENESIS

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

(2009) Hui Nian et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting NRF2 signaling for cancer chemoprevention

(2009) Mi-Kyoung Kwak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Multi-targeted prevention of cancer by sulforaphane

(2008) John D. Clarke et al.   CANCER LETTERS

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates

(2008) Roderick H Dashwood et al.   NUTRITION REVIEWS