Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Small molecular Nrf2 inhibitors as chemosensitizers for cancer therapy

(2020) Hongzhi Lin et al.   Future Medicinal Chemistry

MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress

(2020) Milad Ashrafizadeh et al.   LIFE SCIENCES

ATF4-Dependent NRF2 Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress

(2020) Carmen Sarcinelli et al.   Cancers

Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism

(2020) Di Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox toxicology of environmental chemicals causing oxidative stress

(2020) Fuli Zheng et al.   Redox Biology

Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease

(2020) Rita Maria Concetta Di Martino et al.   ACS Chemical Neuroscience

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer

(2020) Jong-Su Kang et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway

(2020) Yan Xu et al.   Oxidative Medicine and Cellular Longevity

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

(2020) Yi Lu et al.   Science Translational Medicine

Oxidative stress-based therapeutics in COPD

(2020) Peter J. Barnes   Redox Biology

Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors

(2020) Yi Mou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer

(2020) Janine M. DeBlasi et al.   Cancers

NRF2 in Cardiovascular Diseases: a Ray of Hope!

(2020) Ruju Vashi et al.   Journal of Cardiovascular Translational Research

Redox regulation by NRF2 in aging and disease

(2019) Cody J. Schmidlin et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 Activation in Cancer: From DNA to Protein

(2019) Erica W. Cloer et al.   CANCER RESEARCH

PMA-triggered PKCε activity enhances Nrf2-mediated antiviral response on fish rhabdovirus infection

(2019) Yun-Fei Dang et al.   FISH & SHELLFISH IMMUNOLOGY

Potential Applications of NRF2 Inhibitors in Cancer Therapy

(2019) Emiliano Panieri et al.   Oxidative Medicine and Cellular Longevity

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation

(2019) Tamami Fujiki et al.   Scientific Reports

Galectin-1 ameliorates lipopolysaccharide-induced acute lung injury via AMPK-Nrf2 pathway in mice

(2019) Xiao-Ting Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

(2019) Xiaozhen Dai et al.   TRENDS IN MOLECULAR MEDICINE

“NRF2 addiction” in lung cancer cells and its impact on cancer therapy

(2019) Ahmed Hammad et al.   CANCER LETTERS

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes

(2019) Manuel Matzinger et al.   Redox Biology

Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC

(2018) Liang Shi et al.   BIOCHEMICAL PHARMACOLOGY

Regulation and role of nuclear factor-E2-related factor 2 (Nrf2) in multidrug resistance of hepatocellular carcinoma

(2018) Bing Tian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Nrf2 protects human lens epithelial cells against H 2 O 2 -induced oxidative and ER stress: The ATF4 may be involved

(2018) Tian-ju Ma et al.   EXPERIMENTAL EYE RESEARCH

Resistance to gefitinib and cross-resistance to irreversible EGFR-TKIs mediated by disruption of the Keap1-Nrf2 pathway in human lung cancer cells

(2018) Seong-Hee Park et al.   FASEB JOURNAL

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway

(2018) Wei-Yin Wu et al.   Frontiers in Pharmacology

Antioxidant response elements: Discovery, classes, regulation and potential applications

(2018) Azhwar Raghunath et al.   Redox Biology

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Ginsenoside Rb3 protects cardiomyocytes against hypoxia/reoxygenation injury via activating the antioxidation signaling pathway of PERK/Nrf2/HMOX1

(2018) Jing Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy

(2018) Zheng-Yu Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis

(2018) Yuan Liang et al.   PHYTOTHERAPY RESEARCH

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2

(2017) Md. Morshedul Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage

(2017) Mi-Hwi Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease

(2017) Isabel Gameiro et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment

(2017) Nadine Keleku-Lukwete et al.   ANTIOXIDANTS & REDOX SIGNALING

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

(2016) Y. Zhang et al.   BIOCHEMICAL JOURNAL

Oxyresveratrol abrogates oxidative stress by activating ERK–Nrf2 pathway in the liver

(2016) Hee Yoon Choi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Sequential posttranslational modifications regulate PKC degradation

(2016) Yan Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Anti-neuroinflammatory Effect of Emodin in LPS-Stimulated Microglia: Involvement of AMPK/Nrf2 Activation

(2016) Sun Young Park et al.   NEUROCHEMICAL RESEARCH

NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis

(2016) Hui Wang et al.   Science Translational Medicine

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response

(2015) Kristin Zimmermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

(2015) Souvik Dey et al.   JOURNAL OF CLINICAL INVESTIGATION

The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression

(2015) Hiroki Sekine et al.   MOLECULAR AND CELLULAR BIOLOGY

The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2

(2015) Kendra S. Plafker et al.   MOLECULAR BIOLOGY OF THE CELL

Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage

(2015) Loretta O. Iniaghe et al.   NEUROBIOLOGY OF DISEASE

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

(2014) T. Wu et al.   GENES & DEVELOPMENT

Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

(2014) Ghorbangol Ashabi et al.   METABOLIC BRAIN DISEASE

Upregulation of heme oxygenase-1 expression by dehydrodiconiferyl alcohol (DHCA) through the AMPK–Nrf2 dependent pathway

(2014) Junghun Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

Chemopreventive effects of diverse dietary phytochemicals against DMBA-induced hamster buccal pouch carcinogenesis via the induction of Nrf2-mediated cytoprotective antioxidant, detoxification, and DNA repair enzymes

(2013) K. Kavitha et al.   BIOCHIMIE

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

Redox regulation of tumor suppressor PTEN in cancer and aging

(2013) YASUKO KITAGISHI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

A Novel Semisynthetic Flavonoid 7-O-Galloyltaxifolin Upregulates Heme Oxygenase-1 in RAW264.7 Cells via MAPK/Nrf2 Pathway

(2013) Jiří Vrba et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

(2013) Minh Truong Do et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

The small MAF transcription factors MAFF, MAFG and MAFK: Current knowledge and perspectives

(2012) Meenakshi B. Kannan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco-2 cells

(2012) Xiaohan Zhai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

(2012) J-H Kim et al.   ONCOGENE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

PTEN in cancer, metabolism, and aging

(2012) Ana Ortega-Molina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Inhibition of glycogen synthase kinase 3 beta ameliorates liver ischemia reperfusion injury by way of an interleukin-10-mediated immune regulatory mechanism

(2011) Feng Ren et al.   HEPATOLOGY

Carnosic Acid Induces the NAD(P)H: Quinone Oxidoreductase 1 Expression in Rat Clone 9 Cells through the p38/Nuclear Factor Erythroid-2 Related Factor 2 Pathway

(2011) Chia-Wen Tsai et al.   JOURNAL OF NUTRITION

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival

(2010) Xiao-ming Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2

(2010) Kendra S. Plafker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of CK2 in activation of electrophilic genes in endothelial cells by oxidized phospholipids

(2010) Taras Afonyushkin et al.   JOURNAL OF LIPID RESEARCH

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

(2010) Rosaria Varì et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

Protein Kinase CK2 in Health and Disease

(2009) N. A. St-Denis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting the redox sensitive Nrf2–Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones

(2009) Giovanni E Mann et al.   CURRENT OPINION IN PHARMACOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Repression of classical nuclear export by S-nitrosylation of CRM1

(2009) P. Wang et al.   JOURNAL OF CELL SCIENCE

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

(2009) Z. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

PKCδ regulates cortical radial migration by stabilizing the Cdk5 activator p35

(2009) Chun-tao Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif

(2008) Wenge Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways

(2008) Jennifer J. Wolfson et al.   CELLULAR MICROBIOLOGY

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

(2008) Patrick L. Apopa et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver

(2008) Nanao Horike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

TREATMENT WITH THE GLYCOGEN SYNTHASE KINASE-3β INHIBITOR, TDZD-8, AFFECTS TRANSIENT CEREBRAL ISCHEMIA/REPERFUSION INJURY IN THE RAT HIPPOCAMPUS

(2008) Massimo Collino et al.   SHOCK

Negative regulation of cyclin-dependent kinase 5 targets by protein kinase C

(2007) Bogachan Sahin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY