The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

REDD1 knockdown protects H9c2 cells against myocardial ischemia/reperfusion injury through Akt/mTORC1/Nrf2 pathway-ameliorated oxidative stress: An in vitro study

(2019) Peng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of the stress-response protein REDD1 promotes ceramide-induced retinal cell death and JNK activation

(2018) Weiwei Dai et al.   FASEB JOURNAL

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa

(2018) Alonso Sánchez-Cruz et al.   Molecular Neurodegeneration

Müller cells and diabetic retinopathy

(2017) Brandon A. Coughlin et al.   VISION RESEARCH

Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis

(2017) Eva María Medina-Rodríguez et al.   Scientific Reports

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Restoration of Nrf2 Signaling Normalizes the Regenerative Niche

(2015) Marc A. Soares et al.   DIABETES

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Neurodegeneration in Diabetic Retina and Its Potential Drug Targets

(2014) Mohammad Ola et al.   Current Neuropharmacology

Epigenetic modifications of Nrf2-mediated glutamate–cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression

(2014) Manish Mishra et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulated in Development and DNA Damage 1 Is Necessary for Hyperglycemia-induced Vascular Endothelial Growth Factor Expression in the Retina of Diabetic Rodents

(2014) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

(2014) M. D. Dennis et al.   Science Signaling

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

NRF2 plays a protective role in diabetic retinopathy in mice

(2013) Zhenhua Xu et al.   DIABETOLOGIA

mTORC1 Dependent Regulation of REDD1 Protein Stability

(2013) Chia Yee Tan et al.   PLoS One

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

The nuclear localization of glycogen synthase kinase 3β is required its putative PY-nuclear localization sequences

(2012) Sung Hwa Shin et al.   MOLECULES AND CELLS

A defect in Nrf2 signaling constitutes a mechanism for cellular stress hypersensitivity in a genetic rat model of type 2 diabetes

(2011) Milad S. Bitar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diabetic Retinopathy, Superoxide Damage and Antioxidants

(2011) Julia M. Santos et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Müller Glial Cells in Retinal Disease

(2011) Andreas Bringmann et al.   OPHTHALMOLOGICA

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression

(2010) James W. Kaspar et al.   FASEB JOURNAL

Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis

(2010) P. Horak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Quantitative Proteomics Analysis of Subcellular Proteome Localization and Changes Induced by DNA Damage

(2009) François-Michel Boisvert et al.   MOLECULAR & CELLULAR PROTEOMICS

NRF2 Cysteine Residues Are Critical for Oxidant/Electrophile-Sensing, Kelch-Like ECH-Associated Protein-1-Dependent Ubiquitination-Proteasomal Degradation, and Transcription Activation

(2009) X. He et al.   MOLECULAR PHARMACOLOGY

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2

(2009) Wenge Li et al.   NUCLEIC ACIDS RESEARCH

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

(2008) Michael L. Whitney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

(2008) Melanie Theodore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY