Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD
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Title
Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD
Authors
Keywords
Lipid droplets, Lipotoxicity, NAFLD, NASH, Perilipins
Journal
Molecular Metabolism
Volume 50, Issue -, Pages 101115
Publisher
Elsevier BV
Online
2020-11-10
DOI
10.1016/j.molmet.2020.101115
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Note: Only part of the references are listed.- MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease
- (2020) Mohammed Eslam et al. GASTROENTEROLOGY
- Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting
- (2020) Enxiang Zhang et al. JOURNAL OF LIPID RESEARCH
- A single nucleotide polymorphism of PLIN2 is associated with nonalcoholic steatohepatitis and causes phenotypic changes in hepatocyte lipid droplets: A pilot study
- (2020) Claire S. Faulkner et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD
- (2020) Shuoyi Ma et al. LIVER INTERNATIONAL
- Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non‐alcoholic fatty liver disease
- (2020) Yuya Seko et al. LIVER INTERNATIONAL
- Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?
- (2020) Dominika Maciejewska et al. MOLECULES
- Structure and mechanism of human diacylglycerol O-acyltransferase 1
- (2020) Lie Wang et al. NATURE
- Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
- (2020) Kay H. M. Roumans et al. Nature Communications
- Western diet induces severe nonalcoholic steatohepatitis, ductular reaction, and hepatic fibrosis in liver CGI-58 knockout mice
- (2020) Pan Yang et al. Scientific Reports
- Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy
- (2020) Liyang Wang et al. Cell and Bioscience
- Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease
- (2020) Matteo Tardelli WORLD JOURNAL OF GASTROENTEROLOGY
- Lipophagy Impairment Is Associated With Disease Progression in NAFLD
- (2020) Simone Carotti et al. Frontiers in Physiology
- Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice
- (2019) Stacey N. Keenan et al. DIABETES
- A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver
- (2019) Christina Preuss et al. Cells
- Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
- (2019) Kamil Sołtysik et al. Nature Communications
- Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids
- (2019) Manuele Piccolis et al. MOLECULAR CELL
- Autophagy in liver diseases: Time for translation?
- (2019) Manon Allaire et al. JOURNAL OF HEPATOLOGY
- Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet
- (2019) Amar B. Singh et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Hepatic stellate cell activation: A source for bioactive lipids
- (2019) Igor O. Shmarakov et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Hepatocyte Deletion of Triglyceride‐Synthesis Enzyme DGAT 2 Reduces Steatosis without Increasing Inflammation or Fibrosis
- (2019) Nina L. Gluchowski et al. HEPATOLOGY
- The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux
- (2019) Xiaoting Chen et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption
- (2019) Matteo Tardelli et al. JOURNAL OF LIPID RESEARCH
- Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis
- (2019) Soumik BasuRay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
- (2019) Daniel Lindén et al. Molecular Metabolism
- The biogenesis of lipid droplets: Lipids take center stage
- (2019) Mingming Gao et al. PROGRESS IN LIPID RESEARCH
- Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
- (2019) Bhagirath Chaurasia et al. SCIENCE
- Hepatocyte Elovl6 determines ceramide acyl‐chain length and hepatic insulin sensitivity in mice
- (2019) Takashi Matsuzaka et al. HEPATOLOGY
- Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes
- (2019) Micah B. Schott et al. JOURNAL OF CELL BIOLOGY
- Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis
- (2019) Xuelian Xiong et al. MOLECULAR CELL
- Inhibiting Ceramide Synthesis Attenuates Hepatic Steatosis and Fibrosis in Rats With Non-alcoholic Fatty Liver Disease
- (2019) Meng Jiang et al. Frontiers in Endocrinology
- A twist of FATe: Lipid droplets and inflammatory lipid mediators
- (2019) Eva Jarc et al. BIOCHIMIE
- Nuclear envelope–localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis
- (2019) Ji-Yeon Shin et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis
- (2019) Neeta B. Amin et al. Science Translational Medicine
- Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
- (2019) Robert N Helsley et al. eLife
- Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells
- (2019) Tan et al. Cells
- Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
- (2019) Gordon I. Smith et al. JOURNAL OF CLINICAL INVESTIGATION
- Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
- (2019) Charles P. Najt et al. MOLECULAR CELL
- Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly
- (2018) Ariel D. Quiroga et al. BIOCHEMICAL PHARMACOLOGY
- Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis
- (2018) Jihong Lian et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
- (2018) Montserrat A. de la Rosa Rodriguez et al. BMC GENOMICS
- The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets
- (2018) Anete Romanauska et al. CELL
- DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates
- (2018) David G. McLaren et al. Cell Metabolism
- A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes
- (2018) Kirill Bersuker et al. DEVELOPMENTAL CELL
- Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars
- (2018) Panu K. Luukkonen et al. DIABETES CARE
- Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway
- (2018) Xinhong Zhu et al. FOOD AND CHEMICAL TOXICOLOGY
- Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets
- (2018) Matthew A. Mitsche et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase
- (2018) Krishna M. Padmanabha Das et al. JOURNAL OF LIPID RESEARCH
- Fasting and refeeding induces changes in the mouse hepatic lipid droplet proteome
- (2018) David A. Kramer et al. Journal of Proteomics
- A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
- (2018) Noura S. Abul-Husn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lipid Droplets as Immune Modulators in Myeloid Cells
- (2018) Martijn H. den Brok et al. TRENDS IN IMMUNOLOGY
- Role of DGAT enzymes in triacylglycerol metabolism
- (2018) Bhumika Bhatt-Wessel et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- PNPLA3 variant M148 causes resistance to starvation-mediated lipid droplet autophagy in human hepatocytes
- (2018) Florentina Negoita et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Mapping the triglyceride distribution in NAFLD human liver by MALDI imaging mass spectrometry reveals molecular differences in micro and macro steatosis
- (2018) Hussam Alamri et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Omega-3 fatty acids and nonalcoholic fatty liver disease in adults and children
- (2018) Melinda H. Spooner et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis
- (2018) Natalie Krahmer et al. DEVELOPMENTAL CELL
- Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis
- (2018) Brian N. Finck DIABETES
- Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver
- (2018) Aida Habib et al. GUT
- HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease
- (2018) Yanling Ma et al. HEPATOLOGY
- Raman spectroscopy-based insight into lipid droplets presence and contents in liver sinusoidal endothelial cells and hepatocytes
- (2018) Ewelina Szafraniec et al. Journal of Biophotonics
- Splice variant rs72613567 prevents worst histologic outcomes in patients with nonalcoholic fatty liver disease
- (2018) Carlos J. Pirola et al. JOURNAL OF LIPID RESEARCH
- Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity
- (2018) Lu-Min Shih et al. MOLECULES
- Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
- (2018) Sonya A. MacParland et al. Nature Communications
- Decreasing Phosphatidylcholine on the Surface of the Lipid Droplet Correlates with Altered Protein Binding and Steatosis
- (2018) Laura Listenberger et al. Cells
- Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis
- (2017) Cristina Alonso et al. GASTROENTEROLOGY
- The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells
- (2017) Francesca Virginia Bruschi et al. HEPATOLOGY
- The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation
- (2017) Soumik BasuRay et al. HEPATOLOGY
- Metabolic and histological implications of intrahepatic triglyceride content in nonalcoholic fatty liver disease
- (2017) Fernando Bril et al. HEPATOLOGY
- Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK
- (2017) Qi Huang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance
- (2017) Elisa Álvarez Hernández et al. JOURNAL OF CLINICAL INVESTIGATION
- Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
- (2017) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- Differential proteomics profiling identifies LDPs and biological functions in high-fat diet-induced fatty livers
- (2017) Mingwei Liu et al. JOURNAL OF LIPID RESEARCH
- TM6SF2 rs58542926 variant affects postprandial lipoprotein metabolism and glucose homeostasis in NAFLD
- (2017) Giovanni Musso et al. JOURNAL OF LIPID RESEARCH
- Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH
- (2017) George N. Ioannou et al. JOURNAL OF LIPID RESEARCH
- Non-alcoholic fatty liver disease with and without metabolic syndrome: Different long-term outcomes
- (2017) Aki Juhani Käräjämäki et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Activation of the Unfolded Protein Response by Lipid Bilayer Stress
- (2017) Kristina Halbleib et al. MOLECULAR CELL
- Applying systems-level spectral imaging and analysis to reveal the organelle interactome
- (2017) Alex M. Valm et al. NATURE
- Dysregulated expression of proteins associated with ER stress, autophagy and apoptosis in tissues from nonalcoholic fatty liver disease
- (2017) Seungwoo Lee et al. Oncotarget
- ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism
- (2017) Aishwarya Sathyanarayan et al. Cell Reports
- Reduced expression of adipose triglyceride lipase decreases arachidonic acid release and prostacyclin secretion in human aortic endothelial cells
- (2017) Monika Riederer et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets
- (2017) Pengfei Zheng et al. Scientific Reports
- Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis
- (2016) Charles P. Najt et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA
- (2016) Susmita Kaushik et al. Autophagy
- Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver
- (2016) Nuria Martinez-Lopez et al. Cell Metabolism
- Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites
- (2016) You Zhou et al. Clinical Gastroenterology and Hepatology
- The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent
- (2016) Rosellina Margherita Mancina et al. GASTROENTEROLOGY
- Circadian Clock Control of Liver Metabolic Functions
- (2016) Hans Reinke et al. GASTROENTEROLOGY
- Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes
- (2016) Wenyi Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
- (2016) Meric Erikci Ertunc et al. JOURNAL OF LIPID RESEARCH
- Sirtuins and nonalcoholic fatty liver disease
- (2016) Fatiha Nassir et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
- (2016) Violeta I. Gallardo-Montejano et al. Nature Communications
- Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma
- (2016) Junyong Zhang et al. Scientific Reports
- Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation
- (2016) Caleb C. Lord et al. Cell Reports
- Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins
- (2016) Wenwei Zhang et al. Cell Reports
- Liver-specific G0 /G1 switch gene 2 (G0s2) expression promotes hepatic insulin resistance by exacerbating hepatic steatosis in male Wistar rats
- (2016) Yoshiyuki Sugaya et al. Journal of Diabetes
- Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance
- (2016) Xiulan Chen et al. Scientific Reports
- Ces3/TGH Deficiency Attenuates Steatohepatitis
- (2016) Jihong Lian et al. Scientific Reports
- Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Primary Hepatocytes
- (2015) C. Li et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation
- (2015) Wudelehu Wu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
- (2015) Salmaan Ahmed Khan et al. DIABETES
- Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans
- (2015) Manoj Amrutkar et al. DIABETOLOGIA
- Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH
- (2015) Manoj Amrutkar et al. FASEB JOURNAL
- The small GTPase Rab7 as a central regulator of hepatocellular lipophagy
- (2015) Barbara Schroeder et al. HEPATOLOGY
- Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
- (2015) Paola Dongiovanni et al. HEPATOLOGY
- CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis
- (2015) Cédric Langhi et al. HEPATOLOGY
- Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity
- (2015) Silvia Sookoian et al. HEPATOLOGY
- Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis
- (2015) Chao Wang et al. HEPATOLOGY
- Saturated phosphatidic acids mediate saturated fatty acid–induced vascular calcification and lipotoxicity
- (2015) Masashi Masuda et al. JOURNAL OF CLINICAL INVESTIGATION
- Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2
- (2015) You Zhou et al. JOURNAL OF HEPATOLOGY
- Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity
- (2015) Sanda Win et al. JOURNAL OF HEPATOLOGY
- Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis
- (2015) S. Schlager et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Quantitative analysis of the murine lipid droplet-associated proteome during diet-induced hepatic steatosis
- (2015) Salmaan Ahmed Khan et al. JOURNAL OF LIPID RESEARCH
- Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
- (2015) D. Lee Gorden et al. JOURNAL OF LIPID RESEARCH
- Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome
- (2015) Maddalena Parafati et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
- (2015) Susmita Kaushik et al. NATURE CELL BIOLOGY
- New Evidence for the Role of Ceramide in the Development of Hepatic Insulin Resistance
- (2015) Karolina Konstantynowicz-Nowicka et al. PLoS One
- Ceramide as a Mediator of Non-Alcoholic Fatty Liver Disease and Associated Atherosclerosis
- (2015) Takhar Kasumov et al. PLoS One
- Proteomic analysis of murine testes lipid droplets
- (2015) Weiyi Wang et al. Scientific Reports
- Structural and Functional Assessment of Perilipin 2 Lipid Binding Domain(s)
- (2014) Charles P. Najt et al. BIOCHEMISTRY
- Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
- (2014) Yaarit Adamovich et al. Cell Metabolism
- Lipid droplet biogenesis
- (2014) Florian Wilfling et al. CURRENT OPINION IN CELL BIOLOGY
- Molecular speciation and dynamics of oxidized triacylglycerols in lipid droplets: Mass spectrometry and coarse-grained simulations
- (2014) Dariush Mohammadyani et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pathological Features of Fatty Liver Disease
- (2014) Matthew M. Yeh et al. GASTROENTEROLOGY
- Pnpla3I148Mknockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
- (2014) Eriks Smagris et al. HEPATOLOGY
- PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
- (2014) Carlo Pirazzi et al. HUMAN MOLECULAR GENETICS
- Fat-specific Protein 27 (FSP27) Interacts with Adipose Triglyceride Lipase (ATGL) to Regulate Lipolysis and Insulin Sensitivity in Human Adipocytes
- (2014) Tan Hooi Min Grahn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
- (2014) Albert Pol et al. JOURNAL OF CELL BIOLOGY
- Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells
- (2014) Andrea Dichlberger et al. JOURNAL OF LIPID RESEARCH
- Hepatic ATGL mediates PPAR-α signaling and fatty acid channeling through an L-FABP independent mechanism
- (2014) Kuok Teong Ong et al. JOURNAL OF LIPID RESEARCH
- Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
- (2014) Julia Kozlitina et al. NATURE GENETICS
- Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice
- (2014) Rotonya M. Carr et al. PLoS One
- TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content
- (2014) H. Mahdessian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comparative proteomic study reveals 17 -HSD13 as a pathogenic protein in nonalcoholic fatty liver disease
- (2014) W. Su et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
- (2014) Yang-Lin Liu et al. Nature Communications
- Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
- (2014) Hannele Yki-Järvinen Lancet Diabetes & Endocrinology
- Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity
- (2013) Albert Herms et al. CURRENT BIOLOGY
- Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
- (2013) Florian Wilfling et al. DEVELOPMENTAL CELL
- The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an α-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in humans
- (2013) Joëlle Magné et al. FASEB JOURNAL
- Monoacylglycerol Lipase Controls Endocannabinoid and Eicosanoid Signaling and Hepatic Injury in Mice
- (2013) Zongxian Cao et al. GASTROENTEROLOGY
- Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice
- (2013) Rohit A. Sinha et al. HEPATOLOGY
- Perilipin discerns chronic from acute hepatocellular steatosis
- (2013) Lena Maria Pawella et al. JOURNAL OF HEPATOLOGY
- Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
- (2013) Feng Guo et al. JOURNAL OF LIPID RESEARCH
- Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis
- (2013) George N. Ioannou et al. JOURNAL OF LIPID RESEARCH
- Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
- (2013) Quentin M. Anstee et al. Nature Reviews Gastroenterology & Hepatology
- Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
- (2013) R. Volmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease
- (2013) April D. Lake et al. TOXICOLOGICAL SCIENCES
- Nuclear lipid droplets: A novel nuclear domain
- (2012) J.P. Layerenza et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
- (2012) Hae-Ki Min et al. Cell Metabolism
- Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides andde novosynthesized fatty acids in HepG2 cells
- (2012) Haja R. Wurie et al. FEBS Journal
- Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice
- (2012) Jihong Lian et al. HEPATOLOGY
- Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis
- (2012) Christopher Savard et al. HEPATOLOGY
- Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases
- (2012) Thomas O. Eichmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
- (2012) Anne Leroux et al. JOURNAL OF HEPATOLOGY
- Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace
- (2012) György Baffy et al. JOURNAL OF HEPATOLOGY
- The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2
- (2012) Jenson Qi et al. JOURNAL OF LIPID RESEARCH
- LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice
- (2012) Hyeon-Cheol Lee et al. MOLECULAR BIOLOGY OF THE CELL
- Increased risk of cardiovascular disease and chronic kidney disease in NAFLD
- (2012) Enzo Bonora et al. Nature Reviews Gastroenterology & Hepatology
- Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression
- (2012) Yumi Imai et al. PHYSIOLOGICAL GENOMICS
- Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase
- (2011) Natalie Krahmer et al. Cell Metabolism
- Mammalian Triacylglycerol Metabolism: Synthesis, Lipolysis, and Signaling
- (2011) Rosalind A. Coleman et al. CHEMICAL REVIEWS
- Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis
- (2011) Derrick M. Van Rooyen et al. GASTROENTEROLOGY
- Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis
- (2011) Jiang Wei Wu et al. HEPATOLOGY
- The role of lipid droplets in metabolic disease in rodents and humans
- (2011) Andrew S. Greenberg et al. JOURNAL OF CLINICAL INVESTIGATION
- Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
- (2011) Hong Wang et al. JOURNAL OF LIPID RESEARCH
- Lipid body formation during maturation of human mast cells
- (2011) Andrea Dichlberger et al. JOURNAL OF LIPID RESEARCH
- Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption
- (2010) Jaimie N Davis et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
- (2010) S. M. Turpin et al. DIABETOLOGIA
- Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
- (2010) Kuok Teong Ong et al. HEPATOLOGY
- Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication
- (2010) David R. Blais et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Harmeet Malhi et al. JOURNAL OF HEPATOLOGY
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- (2010) So Young Bu et al. JOURNAL OF LIPID RESEARCH
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- (2010) Beate K Straub et al. MODERN PATHOLOGY
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- (2010) Huajin Wang et al. MOLECULAR BIOLOGY OF THE CELL
- Peroxisome Proliferator-Activated Receptor Alpha Target Genes
- (2010) Maryam Rakhshandehroo et al. PPAR Research
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- (2009) Claudio J. Villanueva et al. HEPATOLOGY
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- (2009) Lei O. Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Matteo Ricchi et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
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- (2009) Jessica M. Sapiro et al. JOURNAL OF LIPID RESEARCH
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
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- (2008) Nila Rafiq et al. Clinical Gastroenterology and Hepatology
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- (2008) Anna Kotronen et al. GASTROENTEROLOGY
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- (2008) Kevin M. Korenblat et al. GASTROENTEROLOGY
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- (2008) Montserrat Pinent et al. GENOMICS
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- (2008) Beate Katharina Straub et al. HEPATOLOGY
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- (2008) Yan Qun Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2008) Naga Chalasani et al. JOURNAL OF HEPATOLOGY
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- (2008) Motohiro Sekiya et al. JOURNAL OF LIPID RESEARCH
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- (2008) Stefano Romeo et al. NATURE GENETICS
- Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
- (2007) Puneet Puri et al. GASTROENTEROLOGY
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