Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-05-15
DOI
10.3389/fonc.2018.00160
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation
- (2017) Amit Gupta et al. MOLECULAR CELL
- PIK3CAmutant tumors depend on oxoglutarate dehydrogenase
- (2017) Nina Ilic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence
- (2017) Abeba Demelash et al. Oncotarget
- The KEAP1–NRF2 System in Cancer
- (2017) Keiko Taguchi et al. Frontiers in Oncology
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- 2-Oxoglutarate dehydrogenase is a more significant source of O 2 ·− /H 2 O 2 than pyruvate dehydrogenase in cardiac and liver tissue
- (2016) Ryan J. Mailloux et al. FREE RADICAL BIOLOGY AND MEDICINE
- Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer
- (2016) Evan C. Lien et al. NATURE CELL BIOLOGY
- Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition
- (2016) M Dermit et al. ONCOGENE
- The Dual Roles of NRF2 in Cancer
- (2016) Silvia Menegon et al. TRENDS IN MOLECULAR MEDICINE
- PI3K inhibitors as new cancer therapeutics: implications for clinical trial design
- (2016) Cristian Massacesi et al. OncoTargets and Therapy
- Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
- (2016) Yujun Hao et al. Nature Communications
- NADPH: new oxygen for the ROS theory of aging
- (2016) Pablo J. Fernandez-Marcos et al. Oncotarget
- Fundamentals of cancer metabolism
- (2016) R. J. DeBerardinis et al. Science Advances
- Inhibition of NADPH oxidase protects against metastasis of human lung cancer by decreasing microRNA-21
- (2015) Song Yan et al. ANTI-CANCER DRUGS
- Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and inIn VivoNeurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway
- (2015) Sarah Iqbal et al. MOLECULAR AND CELLULAR BIOLOGY
- The redox biology network in cancer pathophysiology and therapeutics
- (2015) Gina Manda et al. Redox Biology
- NADPH oxidases: an overview from structure to innate immunity-associated pathologies
- (2014) Arvind Panday et al. Cellular & Molecular Immunology
- ROS Function in Redox Signaling and Oxidative Stress
- (2014) Michael Schieber et al. CURRENT BIOLOGY
- Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells
- (2014) Peter V. Usatyuk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- The Promise and Perils of Antioxidants for Cancer Patients
- (2014) Navdeep S. Chandel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
- (2014) Asima Bhattacharyya et al. PHYSIOLOGICAL REVIEWS
- Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway
- (2014) C. Gorrini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The pentose phosphate pathway and cancer
- (2014) Krushna C. Patra et al. TRENDS IN BIOCHEMICAL SCIENCES
- Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation
- (2014) H Huang et al. Cell Death & Disease
- Regulation of the pentose phosphate pathway in cancer
- (2014) Peng Jiang et al. Protein & Cell
- NADPH Oxidases: A Perspective on Reactive Oxygen Species Production in Tumor Biology
- (2013) Jennifer L. Meitzler et al. ANTIOXIDANTS & REDOX SIGNALING
- AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases
- (2013) José M. Arencibia et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer
- (2013) B. Dai et al. CANCER RESEARCH
- PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes
- (2013) Chen Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Drug rechallenge and treatment beyond progression—implications for drug resistance
- (2013) Elizabeth A. Kuczynski et al. Nature Reviews Clinical Oncology
- Reactive Oxygen Species via Redox Signaling to PI3K/AKT Pathway Contribute to the Malignant Growth of 4-Hydroxy Estradiol-Transformed Mammary Epithelial Cells
- (2013) Victor O. Okoh et al. PLoS One
- The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
- (2013) Emilia Kansanen et al. Redox Biology
- Increased signalling of EGFR and IGF1R and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas
- (2012) A Gallardo et al. BRITISH JOURNAL OF CANCER
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt
- (2012) Guo-Xiang Ruan et al. CELL CYCLE
- S-Nitrosylation of EGFR and Src Activates an Oncogenic Signaling Network in Human Basal-Like Breast Cancer
- (2012) C. H. Switzer et al. MOLECULAR CANCER RESEARCH
- Comprehensive molecular portraits of human breast tumours
- (2012) Daniel C. Koboldt et al. NATURE
- Aspirin Use, TumorPIK3CAMutation, and Colorectal-Cancer Survival
- (2012) Xiaoyun Liao et al. NEW ENGLAND JOURNAL OF MEDICINE
- Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS
- (2011) Shampa Chatterjee et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Mitochondrial c-Jun N-terminal Kinase (JNK) Signaling Initiates Physiological Changes Resulting in Amplification of Reactive Oxygen Species Generation
- (2011) Jeremy W. Chambers et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells
- (2011) A Silva et al. LEUKEMIA
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
- (2011) Maria M. Mihaylova et al. NATURE CELL BIOLOGY
- Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure
- (2011) Madhuri S Salker et al. NATURE MEDICINE
- Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- (2011) D. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gain of Nrf2 Function in Non-Small-Cell Lung Cancer Cells Confers Radioresistance
- (2010) Anju Singh et al. ANTIOXIDANTS & REDOX SIGNALING
- COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer
- (2010) Sharon A Glynn et al. BMC CANCER
- Mitochondrial proton and electron leaks
- (2010) Martin Jastroch et al. Essays in Biochemistry
- Reactive oxygen species in cancer
- (2010) Geou-Yarh Liou et al. FREE RADICAL RESEARCH
- NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
- (2010) Young-Don Kwak et al. Molecular Neurodegeneration
- AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
- (2009) Krishna M. Vasudevan et al. CANCER CELL
- When Metabolism Rules Perfusion
- (2009) Eberhard Schulz et al. CIRCULATION RESEARCH
- Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9
- (2009) Jing-song Chen et al. HEPATOLOGY RESEARCH
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- The nuts and bolts of AGC protein kinases
- (2009) Laura R. Pearce et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The PI3K–PTEN tug-of-war, oxidative stress and retinal degeneration
- (2009) Kyung Hwa Kang et al. TRENDS IN MOLECULAR MEDICINE
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function
- (2008) S. Massarweh et al. CANCER RESEARCH
- Regulation of glutathione synthesis
- (2008) Shelly C. Lu MOLECULAR ASPECTS OF MEDICINE
- PI3K pathway alterations in cancer: variations on a theme
- (2008) T L Yuan et al. ONCOGENE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started