Triggering and resolution of inflammation in NASH

Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation in ob/ob and diet-induced obese mice

(2017) Leyre Martínez-Fernández et al.   FASEB JOURNAL

The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress

(2017) Bibiana Rius et al.   FASEB JOURNAL

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

(2017) Soumik BasuRay et al.   HEPATOLOGY

Interferon lambda 4 rs368234815 TT>δG variant is associated with liver damage in patients with nonalcoholic fatty liver disease

(2017) Salvatore Petta et al.   HEPATOLOGY

Liver fat accumulation as a barometer of insulin responsiveness again points to adipose tissue as the culprit

(2017) Yaron Rotman et al.   HEPATOLOGY

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development and Inflammation in Kupffer Cells Induced by Palmitic Acid

(2017) Can Cai et al.   INFLAMMATION

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting hepatic macrophages to treat liver diseases

(2017) Frank Tacke   JOURNAL OF HEPATOLOGY

Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD

(2017) Hannes Hagström et al.   JOURNAL OF HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

(2017) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Low hepatic copper content and PNPLA3 polymorphism in non-alcoholic fatty liver disease in patients without metabolic syndrome

(2017) Albert Friedrich Stättermayer et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Pathology of non-alcoholic fatty liver disease

(2017) Pierre Bedossa   LIVER INTERNATIONAL

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

(2017) Anna Alisi et al.   MEDIATORS OF INFLAMMATION

Epigenetics in non-alcoholic fatty liver disease

(2017) Jooho Lee et al.   MOLECULAR ASPECTS OF MEDICINE

The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2017) Monica D. Chow et al.   MOLECULAR ASPECTS OF MEDICINE

Mechanisms of bile acid mediated inflammation in the liver

(2017) Man Li et al.   MOLECULAR ASPECTS OF MEDICINE

The role of Kupffer cells in hepatic diseases

(2017) Peizhi Li et al.   MOLECULAR IMMUNOLOGY

Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates

(2017) Pi-Xiao Wang et al.   NATURE MEDICINE

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4

(2017) Guang-Nian Zhao et al.   NATURE MEDICINE

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

Targeting nuclear receptors for the treatment of fatty liver disease

(2017) Naoki Tanaka et al.   PHARMACOLOGY & THERAPEUTICS

Macrophages in Nonalcoholic Fatty Liver Disease: A Role Model of Pathogenic Immunometabolism

(2017) Oliver Krenkel et al.   SEMINARS IN LIVER DISEASE

Inflammasomes in Liver Fibrosis

(2017) Fernando Alegre et al.   SEMINARS IN LIVER DISEASE

Association between endotoxemia and histological features of nonalcoholic fatty liver disease

(2017) Hiroyuki Kitabatake et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress

(2017) Adriana Rosas-Villegas et al.   Nutrients

Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model

(2017) Daniela Carlos et al.   Frontiers in Immunology

Liver biopsy in type 2 diabetes mellitus: Steatohepatitis represents the sole feature of liver damage

(2017) Mario Masarone et al.   PLoS One

Hepatokines and non-alcoholic fatty liver disease

(2016) Dariusz M. Lebensztejn et al.   ACTA BIOCHIMICA POLONICA

Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice

(2016) Wilhelmus J. Kwanten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

(2016) Matthew C. Cave et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Progression and Natural History of Nonalcoholic Fatty Liver Disease in Adults

(2016) Andrea Marengo et al.   Clinics in Liver Disease

Natural History of Nonalcoholic Fatty Liver Disease

(2016) George Boon-Bee Goh et al.   DIGESTIVE DISEASES AND SCIENCES

Innate Immunity and Inflammation in NAFLD/NASH

(2016) Marco Arrese et al.   DIGESTIVE DISEASES AND SCIENCES

Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes

(2016) Petra Hirsova et al.   GASTROENTEROLOGY

Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease

(2016) Quentin M. Anstee et al.   GASTROENTEROLOGY

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

(2016) Rosellina Margherita Mancina et al.   GASTROENTEROLOGY

Pathogenesis of Nonalcoholic Steatohepatitis

(2016) Mariana Verdelho Machado et al.   GASTROENTEROLOGY

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis

(2016) Mei Xiang et al.   JOURNAL OF HEPATOLOGY

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis

(2016) Petra Hirsova et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial genome architecture in non-alcoholic fatty liver disease

(2016) Silvia Sookoian et al.   JOURNAL OF PATHOLOGY

Adipokines in nonalcoholic fatty liver disease

(2016) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis

(2016) Alexander Wree et al.   SEMINARS IN LIVER DISEASE

Iron and non-alcoholic fatty liver disease

(2016) Laurence J Britton et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease

(2016) M V Machado et al.   Cell Death & Disease

Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells

(2016) Nancy Magee et al.   Biomed Research International

Progressive Induction of Type 2 Diabetes: Effects of a Reality–Like Fructose Enriched Diet in Young Wistar Rats

(2016) Julie Dupas et al.   PLoS One

NADPH Oxidase–Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment

(2015) Suvarthi Das et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent insights on the role of cholesterol in non-alcoholic fatty liver disease

(2015) Graciela Arguello et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

(2015) Ruth C. Meex et al.   Cell Metabolism

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis

(2015) Marta B. Afonso et al.   CLINICAL SCIENCE

Circulating leptin in non-alcoholic fatty liver disease: a systematic review and meta-analysis

(2015) Stergios A. Polyzos et al.   DIABETOLOGIA

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease

(2015) Paola Dongiovanni et al.   HEPATOLOGY

CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis

(2015) Kai Markus Schneider et al.   HEPATOLOGY

Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes

(2015) Samar H. Ibrahim et al.   HEPATOLOGY

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

(2015) Leila Idrissova et al.   JOURNAL OF HEPATOLOGY

Effects of n-3 fish oil on metabolic and histological parameters in NASH: A double-blind, randomized, placebo-controlled trial

(2015) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner

(2015) Eiji Kakazu et al.   JOURNAL OF LIPID RESEARCH

Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease

(2015) Savannah Tallino et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The indole derivative NecroX-7 improves nonalcoholic steatohepatitis inob/obmice through suppression of mitochondrial ROS/RNS and inflammation

(2015) Hyo Kyun Chung et al.   LIVER INTERNATIONAL

Nonalcoholic fatty liver disease, spleen and psoriasis: New aspects of low-grade chronic inflammation

(2015) Nicola Balato et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development – a potential therapeutic target?

(2015) Paola Dongiovanni et al.   Expert Review of Gastroenterology & Hepatology

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

(2015) Kristine Griffett et al.   Molecular Metabolism

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

Nonalcoholic Fatty Liver Disease, Cardiovascular Risk, and Carotid Inflammation

(2014) Khalid Al-Rasadi et al.   ANGIOLOGY

Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells

(2014) Alba Rebollo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of neutrophils in the development of liver diseases

(2014) Ruonan Xu et al.   Cellular & Molecular Immunology

Toll-like receptor-4 signalling in the progression of non-alcoholic fatty liver disease induced by high-fat and high-fructose diet in mice

(2014) Jing Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

(2014) J. Gautheron et al.   EMBO Molecular Medicine

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

(2014) Tom Luedde et al.   GASTROENTEROLOGY

Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease

(2014) Lindsey G. Albenberg et al.   GASTROENTEROLOGY

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

(2014) M V Machado et al.   GUT

Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition

(2014) Valerie Sapp et al.   HEPATOLOGY

The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease

(2014) Maryann Maximos et al.   HEPATOLOGY

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

(2014) Lay T. Gan et al.   JOURNAL OF HEPATOLOGY

Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia

(2014) Mathilde Di Filippo et al.   JOURNAL OF HEPATOLOGY

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TheUCP2-866 G>A promoter region polymorphism is associated with nonalcoholic steatohepatitis.

(2014) Roberta Fares et al.   LIVER INTERNATIONAL

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

(2014) Salvatore Petta et al.   PLoS One

MicroRNAs in Nonalcoholic Fatty Liver Disease: Novel Biomarkers and Prognostic Tools during the Transition from Steatosis to Hepatocarcinoma

(2014) Manuele Gori et al.   Biomed Research International

Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates

(2013) Kylie Kavanagh et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Oxidized Fatty Acids: A Potential Pathogenic Link Between Fatty Liver and Type 2 Diabetes in Obese Adolescents?

(2013) Nicola Santoro et al.   ANTIOXIDANTS & REDOX SIGNALING

A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia

(2013) Angelo B. Cefalù et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intrahepatic cholestasis in common chronic liver diseases

(2013) Christoph Jüngst et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis

(2013) Bibiana Rius et al.   FASEB JOURNAL

Relationship Between Methylome and Transcriptome in Patients With Nonalcoholic Fatty Liver Disease

(2013) Susan K. Murphy et al.   GASTROENTEROLOGY

Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis

(2013) Cristina López-Vicario et al.   GUT

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

(2013) Maximilian Hatting et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis

(2013) Erika Segear Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance

(2013) Mohamed Asrih et al.   JOURNAL OF ENDOCRINOLOGY

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

A 4-Polymorphism Risk Score Predicts Steatohepatitis in Children With Nonalcoholic Fatty Liver Disease

(2013) Valerio Nobili et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Toll-like receptors and liver disease

(2013) Vivek Kesar et al.   LIVER INTERNATIONAL

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

PNPLA3 I148M polymorphism and progressive liver disease

(2013) Paola Dongiovanni   WORLD JOURNAL OF GASTROENTEROLOGY

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes

(2012) Jun Panee   CYTOKINE

Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose

(2012) Raffaella Crescenzo et al.   EUROPEAN JOURNAL OF NUTRITION

Lipoxin A4 attenuates adipose inflammation

(2012) Emma Börgeson et al.   FASEB JOURNAL

P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice

(2012) Saurabh Chatterjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

Aging promotes the development of diet-induced murine steatohepatitis but not steatosis

(2012) Luis Fontana et al.   HEPATOLOGY

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

(2012) John Zhong Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation and fibrogenesis in steatohepatitis

(2012) Hideki Fujii et al.   JOURNAL OF GASTROENTEROLOGY

IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease

(2012) Salvatore Petta et al.   JOURNAL OF HEPATOLOGY

CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

(2012) Tung-Ming Leung et al.   JOURNAL OF HEPATOLOGY

Leptin modulates lymphocytes' adherence to hepatic stellate cells is associated with oxidative status alterations

(2012) Lina Abu-Tair et al.   MITOCHONDRION

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice

(2012) Sander S. Rensen et al.   PLoS One

Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease

(2012) Alexandra K. Leamy et al.   PROGRESS IN LIPID RESEARCH

Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet

(2012) Volodymyr P. Tryndyak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice

(2012) Zhi-Hong Yang et al.   Diabetology & Metabolic Syndrome

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

(2011) Michael Charlton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

(2011) Kikuko Hotta et al.   BMC Medical Genetics

Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet

(2011) Nicolas Lanthier et al.   FASEB JOURNAL

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

(2011) Nicola Santoro et al.   HEPATOLOGY

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease

(2011) Romina Lomonaco et al.   HEPATOLOGY

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

(2011) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice

(2011) Michaela C Stanton et al.   Journal of Inflammation-London

Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease

(2011) Naim Alkhouri et al.   LIVER INTERNATIONAL

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

Autophagy in nonalcoholic steatohepatitis

(2011) Muhammad Amir et al.   Expert Review of Gastroenterology & Hepatology

A Role for Low Hepatic Copper Concentrations in Nonalcoholic Fatty Liver Disease

(2010) Elmar Aigner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Nuclear Receptors, Inflammation, and Liver Disease: Insights for Cholestatic and Fatty Liver Diseases

(2010) M Arrese et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

MicroRNAs in lipid metabolism

(2010) Carlos Fernández-Hernando et al.   CURRENT OPINION IN LIPIDOLOGY

Leptin: The Prototypic Adipocytokine and its Role in NAFLD

(2010) Claudio Procaccini et al.   CURRENT PHARMACEUTICAL DESIGN

Relationship between portal chronic inflammation and disease severity in paediatric non-alcoholic fatty liver disease

(2010) Anna Alisi et al.   DIGESTIVE AND LIVER DISEASE

Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Surgical Removal of Omental Fat Does Not Improve Insulin Sensitivity and Cardiovascular Risk Factors in Obese Adults

(2010) Elisa Fabbrini et al.   GASTROENTEROLOGY

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

(2010) Yaron Rotman et al.   HEPATOLOGY

Mass spectrometric profiling of oxidized lipid products in human nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2010) Ariel E. Feldstein et al.   JOURNAL OF LIPID RESEARCH

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis

(2010) Ashkan Farhadi et al.   LIVER INTERNATIONAL

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile acid levels are increased in the liver of patients with steatohepatitis

(2009) Márcia M. Aranha et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease

(2009) Claudia Pinto Marques Souza Oliveira et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

(2009) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

Rats Fed Fructose-Enriched Diets Have Characteristics of Nonalcoholic Hepatic Steatosis

(2009) Takahiro Kawasaki et al.   JOURNAL OF NUTRITION

Superoxide anions and hydrogen peroxide inhibit proliferation of activated rat stellate cells and induce different modes of cell death

(2009) Sandra Dunning et al.   LIVER INTERNATIONAL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Decreased Liver Fatty Acid Δ-6 and Δ-5 Desaturase Activity in Obese Patients

(2009) Julia Araya et al.   Obesity

Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1

(2009) Hiroyuki Seki et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Increased Hepatic and Circulating Interleukin-6 Levels in Human Nonalcoholic Steatohepatitis

(2008) Anna Wieckowska et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Disease-Specific Mechanisms of Fibrosis: Hepatitis C Virus and Nonalcoholic Steatohepatitis

(2008) David van der Poorten et al.   Clinics in Liver Disease

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

(2008) Dimitrios Galaris et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Copper Availability Contributes to Iron Perturbations in Human Nonalcoholic Fatty Liver Disease

(2008) Elmar Aigner et al.   GASTROENTEROLOGY

Comprehensive and quantitative proteome profiling of the mouse liver and plasma

(2008) Keane K. Y. Lai et al.   HEPATOLOGY

Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

(2008) Kristiaan Wouters et al.   HEPATOLOGY

Prevention of steatohepatitis by pioglitazone: Implication of adiponectin-dependent inhibition of SREBP-1c and inflammation

(2008) Alain Da Silva Morais et al.   JOURNAL OF HEPATOLOGY

Energy Intake from Beverages Is Increasing among Mexican Adolescents and Adults

(2008) Simon Barquera et al.   JOURNAL OF NUTRITION

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Activation of peroxisome proliferator-activated receptor α by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation

(2007) Claire Z Larter et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The opposing effects of n−3 and n−6 fatty acids

(2007) Gerd Schmitz et al.   PROGRESS IN LIPID RESEARCH