Review
Medicine, General & Internal
Zhi-Lin Luan, Cong Zhang, Wen-Hua Ming, Ying-Zhi Huang, You-Fei Guan, Xiao-Yan Zhang
Summary: This review provides an overview of the importance of nuclear receptors in renal physiology and pathophysiology, and discusses the application of nuclear receptor ligands in the management of kidney diseases.
Article
Biochemistry & Molecular Biology
Fawaz Alasmari, Sary Alsanea, Assim A. Alfadda, Ibrahim O. Alanazi, Mohthash Musambil, Afshan Masood, Faleh Alqahtani, Omer Fantoukh, Abdullah F. Alasmari, Hicham Benabdelkamel
Summary: The study investigated serum proteomic profiling in patients with cannabis use disorder (CUD) compared to healthy controls, identifying 121 significantly differentially expressed proteins. These proteins were found to be linked to various signaling pathways, suggesting potential targets for mitigating the toxic effects of cannabis. Proteins associated with liver X receptor/retinoid X receptor (RXR), farnesoid X receptor/RXR activation, and acute phase response signaling were particularly highlighted in the analysis.
Article
Biochemistry & Molecular Biology
Ulrich Stifel, Giorgio Caratti, Jan Tuckermann
Summary: In this review, the authors discuss the regulatory role of nuclear receptors (NRs) in cellular metabolism of immune cells, particularly macrophages, during the resolution of inflammation. The recent developments in understanding the mechanisms and implications of NRs in immune responses and anti-inflammatory drug design are highlighted.
Article
Cell Biology
Yulian Chen, Huanguo Jiang, Zhikun Zhan, Jindi Lu, Tanwei Gu, Ping Yu, Weimin Liang, Xi Zhang, Shuwen Liu, Huichang Bi, Shilong Zhong, Lan Tang
Summary: Regulating lipid metabolism balance to achieve a healthy lipid homeostasis may be a promising therapy for alleviating hepatosteatosis. Clinical studies have found that in obese patients with a body mass index (BMI) greater than 28, an increase in triglycerides (TG) is accompanied by a decrease in phosphatidylethanolamine (PE). Patients with high TG and low PE levels have shorter survival and poor prognosis.
CELL DEATH & DISEASE
(2023)
Article
Biology
Whitney A. Thiel, Emma J. Esposito, Anna P. Findley, Zachary Blume, Diana M. Mitchell
Summary: Transcriptome analyses reveal that microglia in both human and zebrafish strongly express Apoe and Apoc1 genes. The expression of Apoc1 in microglia has not been well-studied before. PPAR/RXR and LXR/RXR receptors appear to regulate the expression of apolipoproteins in macrophages, but their role in microglia has not been investigated in vivo. This study demonstrates that apoc1 expression in the zebrafish central nervous system is unique to microglia and shows that PPAR/RXR and LXR/RXR modulation differentially regulate the expression of apoc1 and apoeb in microglia during early CNS development. The findings suggest that RXR receptors may be involved in the endogenous induction of apoc1 expression in microglia. Overall, this work highlights the importance of using zebrafish to study the regulation and function of apolipoproteins in the CNS.
Article
Immunology
Padmavathy Ramanarayanan, Guido Heine, Margitta Worm
Summary: This review discusses the roles of vitamin A and vitamin D in B cell development and function, as well as their impacts on immunoglobulin class switching, B cell migration, and homing. The combined effects of 9cRA and calcitriol on B cells are less understood and require further investigation. It is hypothesized that maintaining a balance between vitamin A and vitamin D is crucial for robust immune response and better treatment of disorders characterized by dysregulated immune responses.
IMMUNOLOGY LETTERS
(2023)
Review
Gastroenterology & Hepatology
Lucia Parlati, Marion Regnier, Herve Guillou, Catherine Postic
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide with no effective treatments currently available. Preclinical models have enhanced our understanding of its pathophysiology, and research on new therapeutic targets is ongoing.
Review
Nutrition & Dietetics
Torsten Bohn, M. Luisa Bonet, Patrick Borel, Jaap Keijer, Jean-Francois Landrier, Irina Milisav, Joan Ribot, Patrizia Riso, Brigitte Winklhofer-Roob, Yoav Sharoni, Joana Corte-Real, Yvonne van Helden, Monica Rosa Loizzo, Borut Poljsak, Marisa Porrini, Johannes Roob, Polonca Trebse, Rosa Tundis, Agata Wawrzyniak, Ralph Ruhl, Joanna Dulinska-Litewka
Summary: Intake and tissue levels of carotenoids are associated with reduced risk of chronic diseases, but intervention trials with isolated carotenoid supplements have mostly failed to confirm health benefits. Basic mechanisms include antioxidant actions and activation of nuclear hormone receptor pathways, with potential different mechanisms for different diseases.
NUTRITION RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Mariana Rey, Maria S. Kruse, Rocio N. Magrini-Huaman, Jessica Gomez, Mario J. Simirgiotis, Alejandro Tapia, Gabriela E. Feresin, Hector Coirini
Summary: The study showed that Tessaria absinthioides improves cholesterol levels and regulates liver X receptors (LXRs) expression in a hypercholesterolemic model induced by high-fat diet. The chemical profile of T. absinthioides contains various compounds, among which caffeoylquinic acid and its derivatives may play a key role in modifying lipid profiles and LXRs expression. This is the first in vivo study on T. absinthioides, indicating its potential as a candidate against hypercholesterolemia.
Article
Oncology
Ziquan Li, Cong Zhang, Bintao Qiu, Yuchen Niu, Ling Leng, Siyi Cai, Ye Tian, Terry Jianguo Zhang, Guixing Qiu, Nan Wu, Zhihong Wu, Yipeng Wang
Summary: The study presents the first proteomic profile for understanding the pathogenesis of KFS, identifying 15 potential predictive biomarkers common in two comparisons. The lipid metabolism-related canonical pathways and apolipoproteins may play significant roles in the etiology of KFS, suggesting a possible pathogenesis correlation between KFS and CS.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Samridhi Sharma, Ting Shen, Nitin Chitranshi, Veer Gupta, Devaraj Basavarajappa, Mehdi Mirzaei, Yuyi You, Wojciech Krezel, Stuart L. Graham, Vivek Gupta
Summary: Retinoid X receptors (RXRs) play critical roles in various neurological disorders by regulating gene expression and influencing neurodevelopment, metabolism, and biochemical processes. Abnormal RXR signaling affects neuronal stress and neuroinflammatory networks. Targeting RXRs through pharmacological ligands has shown protective effects in neuronal injury models. This review summarizes the roles of RXR, its interacting partners, and ligands in CNS disorders, providing insights for further research.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Clinical Neurology
Anna Papazoglou, Muhammad Arshaad, Christina Henseler, Johanna Daubner, Karl Broich, Britta Haenisch, Marco Weiergraeber
Summary: Early pharmacoepidemiological studies suggested a potential link between Proton Pump Inhibitors (PPIs) and an increased risk of Alzheimer's Disease and non-AD related dementias, supported by preclinical findings. However, large-scale studies showed inconsistent results. The effects of PPIs on dementia might be related to amyloid clearance, anti-inflammatory properties, and patient-specific pharmacokinetic and pharmacogenomic characteristics. A personalized medicinal approach is necessary to predict the effects of PPIs in the future.
CURRENT ALZHEIMER RESEARCH
(2021)
Review
Urology & Nephrology
Bryce A. Jones, Xiaoxin X. Wang, Komuraiah Myakala, Moshe Levi
Summary: Obesity and chronic kidney disease are increasingly common causes of morbidity and mortality worldwide. Obesity has been identified as an independent cause of chronic kidney disease, known as obesity-related glomerulopathy. Pharmacologic interventions discussed include peroxisome proliferator-activated receptors, the farnesoid X receptor, the Takeda G-protein-coupled receptor 5, and the vitamin D receptor.
SEMINARS IN NEPHROLOGY
(2021)
Article
Medicine, General & Internal
O. Karatas, H. Balci Yuce, M. M. Taskan, F. Gevrek, F. Ucan Yarkac, E. Cacan
Summary: The study found that healthy gingival samples had higher expressions of PPAR-gamma, RXR, VDR, and NF-kappa B, as well as higher fibroblast cell counts and lower inflammatory cell counts.
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Gastroenterology & Hepatology
Vincent Wai-Sun Wong, Won Young Tak, George Boon Bee Goh, Pin-Nan Cheng, Eric J. Lawitz, Zobair M. Younossi, Raj Vuppalanchi, Ziad Younes, Naim Alkhouri, Lulu Wang, Jialuo Liu, Kathryn Kersey, Robert P. Myers, Stephen A. Harrison, Zachary Goodman, Michael Trauner, Manuel Romero-Gomez, Quentin M. Anstee, Mindie H. Nguyen, Takeshi Okanoue
Summary: This study evaluated the performance of noninvasive tests in diagnosing advanced fibrosis due to NASH in white and Asian patients, and found that these tests performed similarly in both groups. However, the sensitivities of NFS, FIB-4, and ELF were low in white and Asian patients younger than 40 years.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Georg Semmler, Alexander Lindorfer, Benedikt Schaefer, Stefan Bartl, Stephanie Hametner-Schreil, Sophie Gensluckner, Lorenz Balcar, Katharina Pomej, Katharina Lampichler, Michael Trauner, Elmar Aigner, Christian Datz, Heinz Zoller, Harald Hofer, Rainer Schoefl, Mattias Mandorfer, Thomas Reiberger, Bernhard Scheiner
Summary: This study retrospectively assessed the safety and clinical outcomes of using direct oral anticoagulants (DOACs) compared to vitamin K antagonist treatment in 47 patients with Budd-Chiari syndrome (BCS) treated at 6 Austrian centers. The results suggest that DOACs may be effective and safe for long-term anticoagulation in patients with BCS. However, larger prospective studies are needed to confirm these findings.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Mathias Jachs, Thomas Reiberger, Peter Ferenci
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Caroline Schwarz, David Chromy, David Bauer, Nikki Duong, Victor Ulrich Schmidbauer, Michael Schwarz, Mattias Mandorfer, Armin Rieger, Michael Trauner, Michael Gschwantler, Thomas Reiberger
Summary: This study retrospectively assessed a group of 1458 HIV-infected patients and found that non-alcoholic fatty liver disease (NAFLD) is common in this population, and may be influenced by metabolic comorbidities and antiretroviral therapy (ART).
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Multidisciplinary Sciences
Lukas Hartl, Benedikt Rumpf, Oliver Domenig, Benedikt Simbrunner, Rafael Paternostro, Mathias Jachs, Marko Poglitsch, Rodrig Marculescu, Michael Trauner, Roman Reindl-Schwaighofer, Manfred Hecking, Mattias Mandorfer, Thomas Reiberger
Summary: The study aimed to evaluate the systemic and hepatic renin-angiotensin system (RAS) fingerprint in advanced chronic liver disease (ACLD). It was found that patients with decompensated ACLD (dACLD) had significantly higher levels of angiotensin I, angiotensin II, and aldosterone in their plasma. Increased angiotensin 1-7 was associated with severe liver disease, portal hypertension, endothelial dysfunction, and inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Matthias Weiss, Anna Chanou, Tamas Schauer, Andrey Tvardovskiy, Stefan Meiser, Ann-Christine Koenig, Tobias Schmidt, Elisabeth Kruse, Henning Ummethum, Manuel Trauner, Marcel Werner, Maxime Lalonde, Stefanie M. Hauck, Antonio Scialdone, Stephan Hamperl
Summary: This study uses site-specific recombination and single-locus chromatin isolation to purify early-efficient (EE) and late-inefficient (LI) replication origins in Saccharomyces cerevisiae. By identifying the protein composition of chromatin regions surrounding these origins, the researchers discover the microtubule-binding Ask1/DASH complex as a factor regulating replication timing (RT) and chromosomal organization. Targeting Ask1 to specific origin sites advances RT, while global degradation of Ask1 or inhibiting microtubule dynamics alters the RT of a subset of origins.
Article
Gastroenterology & Hepatology
Lorenz Balcar, Bernhard Scheiner, Markus Urheu, Patrick Weinberger, Rafael Paternostro, Benedikt Simbrunner, Georg Semmler, Claudia Willheim, Matthias Pinter, Peter Ferenci, Michael Trauner, Thomas Reiberger, Albert Friedrich Staettermayer, Mattias Mandorfer
Summary: The TM6SF2 rs58542926 SNP can modulate the susceptibility for (advanced) chronic liver disease ([A]CLD). It was found that harboring the TM6SF2 T-allele increased the risk of hepatic decompensation/liver transplantation/liver-related death, independently of baseline liver disease severity.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Gastroenterology & Hepatology
Laura Turco, Thomas Reiberger, Giovanni Vitale, Vincenzo La Mura
Summary: Portal hypertension is a common complication of cirrhosis and plays a crucial role in hepatic decompensation. Carvedilol, a non-selective beta-blocker, has shown superior efficacy in reducing portal hypertension compared to traditional beta-blockers, making it a preferred treatment option for clinically significant portal hypertension in patients with cirrhosis.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Georg Semmler, Zhenwei Yang, Laurenz Fritz, Fiona Koeck, Benedikt Silvester Hofer, Lorenz Balcar, Lukas Hartl, Mathias Jachs, Katharina Stopfer, Anna Schedlbauer, Daniela Neumayer, Jurij Maurer, Theresa Muellner-Bucsics, Benedikt Simbrunner, Bernhard Scheiner, Michael Trauner, Mattias Mandorfer, Thomas Reiberger, David Josef Maria Bauer
Summary: This retrospective cohort study aimed to determine the prognostic relevance of liver stiffness measurements (LSMs) dynamics over time for liver-related events and death in patients with chronic liver disease. The results showed that LSM dynamics could accurately predict hepatic decompensation and were more effective than other indicators in altering risk assessment.
Article
Gastroenterology & Hepatology
Britta F. Zecher, David Ellinghaus, Sebastian Schloer, Annika Niehrs, Benedetta Padoan, Martin E. Baumdick, Yuko Yuki, Maureen P. Martin, Dawid Glow, Jennifer Schroeder-Schwar, Jennifer Niersch, Sebastien Brias, Luisa M. Mueller, Robin Habermann, Paul Kretschmer, Tristan Frueh, Janis Daenekas, Malte H. Wehmeyer, Tobias Poch, Marcial Sebode, IPSCSG, Eva Ellinghaus, Frauke Degenhardt, Christian Koerner, Angelique Hoelzemer, Boris Fehse, Karl J. Oldhafer, Udo Schumacher, Guido Sauter, Mary Carrington, Andre Franke, Madeleine J. Bunders, Schramm Christoph, Marcus Altfeld
Summary: This study identified a strong association of HLA-DP A1*02:01 similar to DPB1*01:01 with PSC and revealed the role of NKp44+NK cells recognizing HLA-DPA1*02:01-DPB1*01:01 expressed on cholangiocytes in PSC pathogenesis.
Letter
Gastroenterology & Hepatology
Mathias Jachs, Mattias Mandorfer, Thomas Reiberger
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Antonio Guerrero, Laura del Campo, Fabio Piscaglia, Bernhard Scheiner, Guohong Han, Francesco Violi, Carlos-Noronha Ferreira, Luis Tellez, Thomas Reiberger, Stefania Basili, Javier Zamora, Agustin Albillos
Summary: This study used an individual patient data meta-analysis to demonstrate the safety and efficacy of anticoagulation in the recanalization of portal vein thrombosis in patients with cirrhosis. Anticoagulation reduces all-cause mortality, but at the expense of increasing non-portal hypertension-related bleeding.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Benedikt Silvester Hofer, Benedikt Simbrunner, Lukas Hartl, Mathias Jachs, Lorenz Balcar, Rafael Paternostro, Philipp Schwabl, Georg Semmler, Bernhard Scheiner, Michael Trauner, Mattias Mandorfer, Thomas Reiberger
Summary: This study found that alcohol abstinence can lead to recompensation of hepatic function and significantly reduce liver-related mortality in patients with decompensated alcohol-related cirrhosis.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Tomas Machacek, Claudia D. Fuchs, Franziska Winkelmann, Marcus Frank, Hubert Scharnagl, Tatjana Stojakovic, Martina Sombetzki, Michael Trauner
Summary: In this study, the researchers evaluated the effect of polyhydroxylated bile acids (BAs) on the inflammation and fibrosis caused by Schistosoma mansoni infection. They found that mice lacking the Bsep gene showed less hepatic inflammation and fibrosis after infection, which could be attributed to the changes in bile acid composition and blood pH resulting from the loss of Bsep gene, affecting parasite fecundity and thus attenuating the development of S. mansoni-induced hepatic inflammation and fibrosis.
LIVER INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katharina Lampichler, Georg Semmler, Katharina Woeran, Benedikt Simbrunner, Mathias Jachs, Lukas Hartl, David Josef Maria Bauer, Lorenz Balcar, Lukas Burghart, Michael Trauner, Dietmar Tamandl, Ahmed Ba-Ssalamah, Mattias Mandorfer, Thomas Reiberger, Bernhard Scheiner, Martina Scharitzer
Summary: This study aimed to compare the radiological features between PSVD and cirrhosis. The results showed that compared to cirrhosis, patients with PSVD were younger and had lower HVPG, liver stiffness, and MELD. CT/MRI results revealed that PSVD patients had more intrahepatic portal tract abnormalities, FNH-like lesions, and abnormal liver morphology. A specific radiological feature of PSVD identified in gadoxetic acid-enhanced MRI was periportal hyperintensity in the HBP.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)