The short isoform of PML-RARα activates the NRF2/HO-1 pathway through a direct interaction with NRF2

Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells

(2016) Shoichi Nishimoto et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

(2015) Qian Qian Wang et al.   Oncotarget

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1

(2015) Sally-Anne Heasman et al.   Oncotarget

Rexinoid inhibits Nrf2-mediated transcription through retinoid X receptor alpha

(2014) Jiaguo Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer

(2014) Akhileshwar Namani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells

(2014) M Valenzuela et al.   BRITISH JOURNAL OF CANCER

Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs

(2014) Xiu Jun Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia

(2014) Julien Ablain et al.   INTERNATIONAL JOURNAL OF CANCER

The PML domain of PML-RAR  blocks senescence to promote leukemia

(2014) K. Korf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

(2013) Melanie Theodore Malloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment

(2011) E. Goto et al.   BLOOD

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs

(2011) Xiuwen Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curing APL through PML/RARA degradation by As2O3

(2011) Valerie Lallemand-Breitenbach et al.   TRENDS IN MOLECULAR MEDICINE

PML/RARα Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia

(2010) Kankan Wang et al.   CANCER CELL

NF-κB–Inhibited Acute Myeloid Leukemia Cells Are Rescued from Apoptosis by Heme Oxygenase-1 Induction

(2010) Stuart A. Rushworth et al.   CANCER RESEARCH

Cell-cycle regulation and dynamics of cytoplasmic compartments containing the promyelocytic leukemia protein and nucleoporins

(2009) A. Jul-Larsen et al.   JOURNAL OF CELL SCIENCE

HO-1 underlies resistance of AML cells to TNF-induced apoptosis

(2008) S. A. Rushworth et al.   BLOOD