Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice

(2013) Feng Guo et al.   JOURNAL OF LIPID RESEARCH

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficientob/obMice from the Toxicity of Sepsis

(2012) Kenneth R. Feingold et al.   ENDOCRINOLOGY

Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice

(2012) Claudia D. Fuchs et al.   HEPATOLOGY

Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition

(2011) Michael Charlton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis

(2011) Jiang Wei Wu et al.   HEPATOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

The Impact of Human Gene Polymorphisms on HCV Infection and Disease Outcome

(2011) Esperance Schaefer et al.   SEMINARS IN LIVER DISEASE

Lack of PPARα exacerbates lipopolysaccharide-induced liver toxicity through STAT1 inflammatory signaling and increased oxidative/nitrosative stress

(2011) Seong Ho Yoo et al.   TOXICOLOGY LETTERS

Macrophage Adipose Triglyceride Lipase Deficiency Attenuates Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice

(2010) Bart Lammers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Inflammatory Pathways in Liver Homeostasis and Liver Injury

(2008) Frank Tacke et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis

(2008) Brendan N. Reid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH

Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance

(2008) Masaki Kato et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY