The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases

p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)

(2021) Maya Maor-Nof et al.   CELL

Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities

(2021) Jannik Prasuhn et al.   Frontiers in Cell and Developmental Biology

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology

(2021) Boris Guennewig et al.   Scientific Reports

Moving Toward Patient-Tailored Treatment in ALS and FTD: The Potential of Genomic Assessment as a Tool for Biological Discovery and Trial Recruitment

(2021) Iris J. Broce et al.   Frontiers in Neuroscience

The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration

(2021) Eric Sah et al.   Life-Basel

Subtle genomic DNA damage induces intraneuronal production of amyloid‐β (1‐42) by increasing β‐secretase activity

(2021) Hrishita Das et al.   FASEB JOURNAL

Understanding the role of cysteine in ferroptosis: progress & paradoxes

(2021) Carson D. Poltorack et al.   FEBS Journal

Neuronal enhancers are hotspots for DNA single-strand break repair

(2021) Wei Wu et al.   NATURE

Rapid initiation of cell cycle reentry processes protects neurons from amyloid-β toxicity

(2021) Stefania Ippati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Response to DNA Damage

(2021) Ziye Rong et al.   Frontiers in Cell and Developmental Biology

Role of Oxidative Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis: Antioxidant Metalloenzymes and Therapeutic Strategies

(2021) Pavlína Hemerková et al.   Biomolecules

Involvement of ferroptosis in human motor neuron cell death

(2021) Tsuyoshi Matsuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DNA damage as a mechanism of neurodegeneration in ALS and a contributor to astrocyte toxicity

(2021) Jannigje Rachel Kok et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metformin attenuates rotenone-induced oxidative stress and mitochondrial damage via the AKT/Nrf2 pathway

(2021) Nikita Katila et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

(2021) Tanisha Singh et al.   Scientific Reports

Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice

(2021) Liuji Chen et al.   Scientific Reports

PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s Disease

(2021) Wen Li et al.   Frontiers in Cell and Developmental Biology

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

(2021) Marie-France Langelier et al.   Nature Communications

Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic Lateral Sclerosis: Lessons From Drosophila Models

(2021) Sharifah Anoar et al.   Frontiers in Neuroscience

Contributions of DNA Damage to Alzheimer’s Disease

(2020) Xiaozeng Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA damage and repair in Parkinson's disease: Recent advances and new opportunities

(2020) Claudia P. Gonzalez‐Hunt et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD

(2020) Nadja S. Andrade et al.   Molecular Neurodegeneration

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

(2020) Yevgeniya A. Abramzon et al.   Frontiers in Neuroscience

Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins

(2020) Masin Abo-Rady et al.   Stem Cell Reports

DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

(2020) Byung Woo Kim et al.   Acta Neuropathologica Communications

Senescence in Post-Mitotic Cells: A Driver of Aging?

(2020) Thomas von Zglinicki et al.   ANTIOXIDANTS & REDOX SIGNALING

Damage in Mitochondrial DNA Associated with Parkinson's Disease

(2020) Rebeca Martín-Jiménez et al.   DNA AND CELL BIOLOGY

Impairment of Lysosome Function and Autophagy in Rare Neurodegenerative Diseases

(2020) Frédéric Darios et al.   JOURNAL OF MOLECULAR BIOLOGY

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

(2020) Catherine R. Lammert et al.   NATURE

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

(2020) Ping-Chieh Pao et al.   Nature Communications

Expression of Mutant Ubiquitin and Proteostasis Impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex Brains

(2020) Bert M Verheijen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Spotlight on Ferroptosis: Iron-Dependent Cell Death in Alzheimer’s Disease

(2020) Azhaar Ashraf et al.   Frontiers in Aging Neuroscience

Profile of MIF in Developing Hippocampus: Association With Cell Proliferation and Neurite Outgrowth

(2020) Xuejun Chai et al.   Frontiers in Molecular Neuroscience

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

(2020) Kathleen M. Farmer et al.   Acta Neuropathologica Communications

The Intersection of DNA Damage Response and Ferroptosis—A Rationale for Combination Therapeutics

(2020) Po-Han Chen et al.   Biology-Basel

The role of DNA damage response in amyotrophic lateral sclerosis

(2020) Yu Sun et al.   Essays in Biochemistry

Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations

(2020) Anna Konopka et al.   Molecular Neurodegeneration

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis

(2020) Terry R. Suk et al.   Molecular Neurodegeneration

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

(2020) Sarah J. Tabrizi et al.   Nature Reviews Neurology

Mechanisms of Pathogenic Tau and Aβ Protein Spreading in Alzheimer’s Disease

(2020) Paolo d‘Errico et al.   Frontiers in Aging Neuroscience

An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3

(2020) Yasuaki Watanabe et al.   iScience

Molecular and Cellular Mechanisms Affected in ALS

(2020) Laura Le Gall et al.   Journal of Personalized Medicine

Do TUNEL and Other Apoptosis Assays Detect Cell Death in Preclinical Studies?

(2020) Razmik Mirzayans et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

(2019) Luis M. Polo et al.   Cell Reports

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

(2019) Archana Prasad et al.   Frontiers in Molecular Neuroscience

Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/− mice

(2019) Jida El Hajjar et al.   Scientific Reports

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

(2019) Joy Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

(2019) Elizaveta E Alemasova et al.   NUCLEIC ACIDS RESEARCH

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

(2019) Katja Burk et al.   ACTA NEUROPATHOLOGICA

FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy

(2019) Lara Marrone et al.   ACTA NEUROPATHOLOGICA

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis

(2019) Erika N Guerrero et al.   HUMAN MOLECULAR GENETICS

Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in C9ORF72-ALS/FTD

(2019) Rodrigo Lopez-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

(2019) Niraj M. Shanbhag et al.   Acta Neuropathologica Communications

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

Autophagy in Neurons

(2019) Andrea K.H. Stavoe et al.   Annual Review of Cell and Developmental Biology

DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms

(2019) Arwa A. Abugable et al.   DNA REPAIR

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

(2019) Sneham Tiwari et al.   International Journal of Nanomedicine

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Damage Repair in Huntington’s Disease and Other Neurodegenerative Diseases

(2019) T. Maiuri et al.   Neurotherapeutics

Autophagy: A Player in response to Oxidative Stress and DNA Damage

(2019) Serena Galati et al.   Oxidative Medicine and Cellular Longevity

Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

(2019) Ross Nortley et al.   SCIENCE

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

(2019) Allison J. Schaser et al.   Scientific Reports

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease

(2019) Jing Tian et al.   Science Translational Medicine

Axonal Transport and Mitochondrial Function in Neurons

(2019) Amrita Mandal et al.   Frontiers in Cellular Neuroscience

Motor Neuron Susceptibility in ALS/FTD

(2019) Audrey M. G. Ragagnin et al.   Frontiers in Neuroscience

Proteostasis failure and cellular senescence in long‐term cultured postmitotic rat neurons

(2019) Shoma Ishikawa et al.   AGING CELL

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases

(2019) Fangfang Lu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint

(2019) Joyce P.Y. Mak et al.   MOLECULAR CANCER THERAPEUTICS

Oxidative DNA Damage Signalling in Neural Stem Cells in Alzheimer’s Disease

(2019) Marcelina Kieroń et al.   Oxidative Medicine and Cellular Longevity

Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment

(2019) Matthew Regier et al.   NEURAL PLASTICITY

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

(2019) Anna Cozzi et al.   Stem Cell Reports

ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?

(2019) Rita Mejzini et al.   Frontiers in Neuroscience

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The central role of DNA damage and repair in CAG repeat diseases

(2018) Thomas H. Massey et al.   Disease Models & Mechanisms

Overactive BRCA1 Affects Presenilin 1 in Induced Pluripotent Stem Cell-Derived Neurons in Alzheimer’s Disease

(2018) Michalina Wezyk et al.   JOURNAL OF ALZHEIMERS DISEASE

Enhanced neuroinflammatory responses after systemic LPS injection in IL-32β transgenic mice

(2018) Sabita Neupane et al.   JOURNAL OF CHEMICAL NEUROANATOMY

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

(2018) Somaira Nowsheen et al.   NATURE CELL BIOLOGY

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

NAD+supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

(2018) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons

(2018) Julia Higelin et al.   Stem Cell Research

Disruption of ER−mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis

(2018) Dawn H. W. Lau et al.   Cell Death & Disease

Abnormal RNA stability in amyotrophic lateral sclerosis

(2018) E. M. Tank et al.   Nature Communications

Modeling Late-Onset Sporadic Alzheimer’s Disease through BMI1 Deficiency

(2018) Anthony Flamier et al.   Cell Reports

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity inDrosophilaGlutamatergic Neurons

(2018) Wangchao Xu et al.   JOURNAL OF NEUROSCIENCE

C9orf72-mediated ALS and FTD: multiple pathways to disease

(2018) Rubika Balendra et al.   Nature Reviews Neurology

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis

(2018) Danilo B. Medinas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

(2018) Chiara Milanese et al.   Cell Death & Disease

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

(2018) Haibo Wang et al.   Nature Communications

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis

(2018) L. McGurk et al.   Acta Neuropathologica Communications

Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex

(2018) Lindsay A. Welikovitch et al.   ACTA NEUROPATHOLOGICA

Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damage

(2018) Xu-Dong Wang et al.   DNA REPAIR

The Emerging Role of DNA Damage in the Pathogenesis of the C9orf72 Repeat Expansion in Amyotrophic Lateral Sclerosis

(2018) Anna Konopka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Somatic APP gene recombination in Alzheimer’s disease and normal neurons

(2018) Ming-Hsiang Lee et al.   NATURE

Mechanisms of DNA damage, repair, and mutagenesis

(2017) Nimrat Chatterjee et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease

(2017) Yannis Gerakis et al.   FEBS Journal

The role of mitochondrial ROS in the aging brain

(2017) Rhoda Stefanatos et al.   FEBS LETTERS

The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis

(2017) Manal A. Farg et al.   HUMAN MOLECULAR GENETICS

More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy

(2017) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy Roles in the Modulation of DNA Repair Pathways

(2017) Luciana Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

(2017) Haibo Wang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Genome instability in Alzheimer disease

(2017) Yujun Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Overcoming the divide between ataxias and spastic paraplegias: Shared phenotypes, genes, and pathways

(2017) Matthis Synofzik et al.   MOVEMENT DISORDERS

C9orf72 expansion disrupts ATM-mediated chromosomal break repair

(2017) Callum Walker et al.   NATURE NEUROSCIENCE

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Enhanced dopaminergic neurotoxicity mediated by MPTP in IL-32β transgenic mice

(2017) Yu Yeon Jung et al.   NEUROCHEMISTRY INTERNATIONAL

Sirt6 alters adult hippocampal neurogenesis

(2017) Eitan Okun et al.   PLoS One

DNA strand breaks and TDP-43 mislocation are absent in the murine hSOD1G93A model of amyotrophic lateral sclerosis in vivo and in vitro

(2017) Diane Penndorf et al.   PLoS One

Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neurons

(2017) Parimala Narne et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

(2017) Graeme Hewitt et al.   TRENDS IN CELL BIOLOGY

Neuroprotective Functions for the Histone Deacetylase SIRT6

(2017) Shai Kaluski et al.   Cell Reports

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

A novel form of necrosis, TRIAD, occurs in human Huntington’s disease

(2017) Emiko Yamanishi et al.   Acta Neuropathologica Communications

A novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia

(2017) Fernando Palluzzi et al.   PLoS One

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease

(2016) Magdalena Misiak et al.   AGING CELL

DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice

(2016) Degui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nucleophosmin: from structure and function to disease development

(2016) Joseph K. Box et al.   BMC MOLECULAR BIOLOGY

Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies

(2016) John H. T. Power et al.   BRAIN PATHOLOGY

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective Effects of Antidepressants via Upregulation of Neurotrophic Factors in the MPTP Model of Parkinson’s Disease

(2016) Sina Shadfar et al.   MOLECULAR NEUROBIOLOGY

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

(2016) Nicolas C. Hoch et al.   NATURE

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons

(2016) Rodrigo Lopez-Gonzalez et al.   NEURON

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease

(2016) Sara Sepe et al.   Cell Reports

Nucleolar PARP-1 Expression Is Decreased in Alzheimer’s Disease: Consequences for Epigenetic Regulation of rDNA and Cognition

(2016) Jianying Zeng et al.   NEURAL PLASTICITY

DNA Damage Response and Autophagy: A Meaningful Partnership

(2016) Aristides G. Eliopoulos et al.   Frontiers in Genetics

Maintenance of Genome Stability

(2016) Jiadong Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43

(2015) Adam K. Walker et al.   ACTA NEUROPATHOLOGICA

Involvement of inflammation in Alzheimer’s disease pathogenesis and therapeutic potential of anti-inflammatory agents

(2015) Sina Shadfar et al.   ARCHIVES OF PHARMACAL RESEARCH

Impaired DNA Damage Repair as a Common Feature of Neurodegenerative Diseases and Psychiatric Disorders

(2015) H. Shiwaku et al.   CURRENT MOLECULAR MEDICINE

Autophagy in DNA Damage Response

(2015) Piotr Czarny et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms and Consequences of Double-Strand DNA Break Formation in Chromatin

(2015) Wendy J. Cannan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

DNA damage in neurodegenerative diseases

(2015) Fabio Coppedè et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Huntingtin facilitates selective autophagy

(2015) Amir Gelman et al.   NATURE CELL BIOLOGY

Overexpression of nuclear FUS induces neuronal cell death

(2015) H. Suzuki et al.   NEUROSCIENCE

The current state of eukaryotic DNA base damage and repair

(2015) Nicholas C. Bauer et al.   NUCLEIC ACIDS RESEARCH

TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

(2015) Laura De Conti et al.   NUCLEIC ACIDS RESEARCH

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

(2015) Shangyu Dang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX

(2015) J-J Guan et al.   Cell Death & Disease

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

BAX channel activity mediates lysosomal disruption linked to Parkinson disease

(2014) Jordi Bové et al.   Autophagy

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch

(2014) E. Lopez-Arribillaga et al.   DEVELOPMENT

DNA double-strand break repair pathway choice and cancer

(2014) Tomas Aparicio et al.   DNA REPAIR

NAD attenuates oxidative DNA damages induced by amyloid beta-peptide in primary rat cortical neurons

(2014) M.-F. Wu et al.   FREE RADICAL RESEARCH

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

(2014) Haiyan Qiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Poly-A Binding Protein-1 Localization to a Subset of TDP-43 Inclusions in Amyotrophic Lateral Sclerosis Occurs More Frequently in Patients Harboring an Expansion inC9orf72

(2014) Leeanne McGurk et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage

(2014) Q. Deng et al.   JOURNAL OF NEUROSCIENCE

Necroptosis, a novel type of programmed cell death, contributes to early neural cells damage after spinal cord injury in adult mice

(2014) Ming Liu et al.   JOURNAL OF SPINAL CORD MEDICINE

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease

(2014) Chandrika Canugovi et al.   NEUROBIOLOGY OF AGING

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness

(2014) I Bandey et al.   ONCOGENE

ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells

(2014) Meryem Alagoz et al.   PLoS One

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

(2013) Valasani Koteswara Rao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calpain 1 induce lysosomal permeabilization by cleavage of lysosomal associated membrane protein 2

(2013) Gloria E. Villalpando Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A single strand that links multiple neuropathologies in human disease

(2013) John J. Reynolds et al.   BRAIN

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

(2013) Adam S. Mastrocola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia

(2013) Michael Fricker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal cell death at a glance

(2013) S. Aits et al.   JOURNAL OF CELL SCIENCE

Nucleic acid oxidation: an early feature of Alzheimer's disease

(2013) Melissa A. Bradley-Whitman et al.   JOURNAL OF NEUROCHEMISTRY

Determination of apoptotic and necrotic cell death in vitro and in vivo

(2013) Tom Vanden Berghe et al.   METHODS

Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

(2013) K Nho et al.   MOLECULAR PSYCHIATRY

The response to DNA damage during differentiation: Pathways and consequences

(2013) Paola Fortini et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

(2013) Elsa Suberbielle et al.   NATURE NEUROSCIENCE

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

(2013) Wen-Yuan Wang et al.   NATURE NEUROSCIENCE

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

(2013) Yunjong Lee et al.   NATURE NEUROSCIENCE

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Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides

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A role for p53 in the regulation of lysosomal permeability by Δ9-tetrahydrocannabinol in rat cortical neurones: implications for neurodegeneration

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Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production

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DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates

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Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration

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