Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 10, Pages 4696-4705
Publisher
Proceedings of the National Academy of Sciences
Online
2019-02-16
DOI
10.1073/pnas.1818415116
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
- (2018) Haibo Wang et al. Nature Communications
- Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease
- (2017) Velmarini Vasquez et al. JOURNAL OF ALZHEIMERS DISEASE
- TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation
- (2016) Akira Ishiguro et al. GENES TO CELLS
- Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage
- (2016) Sarah J. Hill et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43/FUS in motor neuron disease: Complexity and challenges
- (2016) Erika N. Guerrero et al. PROGRESS IN NEUROBIOLOGY
- TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
- (2015) Laura De Conti et al. NUCLEIC ACIDS RESEARCH
- TDP-43 regulatesβ-adducin(Add2) transcript stability
- (2015) Luisa Costessi et al. RNA Biology
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
- (2014) Nael H. Alami et al. NEURON
- The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids
- (2014) P.-H. Kuo et al. NUCLEIC ACIDS RESEARCH
- Tau pathology involves protein phosphatase 2A in Parkinsonism-dementia of Guam
- (2014) M. Arif et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons
- (2013) Wen-Yuan Wang et al. NATURE NEUROSCIENCE
- The ATM protein kinase: regulating the cellular response to genotoxic stress and more
- (2013) Yosef Shiloh et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins
- (2013) M. L. Hegde et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Screens in Human Cells Using the CRISPR-Cas9 System
- (2013) Tim Wang et al. SCIENCE
- Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks
- (2012) Jinping Liu et al. CELL CYCLE
- Enhancement of NEIL1 Protein-initiated Oxidized DNA Base Excision Repair by Heterogeneous Nuclear Ribonucleoprotein U (hnRNP-U) via Direct Interaction
- (2012) Muralidhar L. Hegde et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neurodegeneration-associated TDP-43 Interacts with Fragile X Mental Retardation Protein (FMRP)/Staufen (STAU1) and Regulates SIRT1 Expression in Neuronal Cells
- (2012) Zhipeng Yu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Caenorhabditis elegansRNA-processing Protein TDP-1 Regulates Protein Homeostasis and Life Span
- (2012) Tao Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
- (2012) Y. Kawahara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A harmonized classification system for FTLD-TDP pathology
- (2011) Ian R. A. Mackenzie et al. ACTA NEUROPATHOLOGICA
- Regulation of Autophagy by Neuropathological Protein TDP-43
- (2011) Jayarama Krishnan Bose et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 Is a Transcriptional Repressor
- (2011) Avin S. Lalmansingh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways
- (2011) Vivek Swarup et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase
- (2011) K. Asagoshi et al. NUCLEIC ACIDS RESEARCH
- The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism
- (2011) Chunxing Yang et al. PLoS One
- Genome-Wide Mapping of DNA Strand Breaks
- (2011) Frédéric Leduc et al. PLoS One
- The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
- (2010) Michael R. Lieber Annual Review of Biochemistry
- Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron
- (2010) Muralidhar L. Hegde et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy
- (2010) N. F. Liachko et al. JOURNAL OF NEUROSCIENCE
- The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number
- (2010) Senyene E. Hunter et al. METHODS
- TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis
- (2009) Lien-Szu Wu et al. GENESIS
- Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
- (2009) Brian D. Freibaum et al. JOURNAL OF PROTEOME RESEARCH
- Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs
- (2009) Jung-Hee Lee et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations
- (2009) Satomi Maekawa et al. NEUROPATHOLOGY
- Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells
- (2008) Muralidhar L Hegde et al. CELL RESEARCH
- Generation of spinal motor neurons from human fetal brain-derived neural stem cells: Role of basic fibroblast growth factor
- (2008) Paivi M. Jordan et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80
- (2008) L. Wei et al. MOLECULAR AND CELLULAR BIOLOGY
- Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
- (2008) Nicole Bennardo et al. PLoS Genetics
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started