Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

Pre-Clinical Detection of Alzheimer's Disease Using FDG-PET, with or without Amyloid Imaging

(2017) Lisa Mosconi et al.   JOURNAL OF ALZHEIMERS DISEASE

2012 Alzheimer’s disease facts and figures

(2012)   Alzheimers & Dementia

Plasma Signaling Proteins in Persons at Genetic Risk for Alzheimer Disease

(2012) John M. Ringman et al.   ARCHIVES OF NEUROLOGY

Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition

(2012) Julie M. Bugg   ARCHIVES OF NEUROLOGY

Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience

(2012) Orwa Aboud et al.   BMC Medicine

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase Cϵ

(2012) Abhik Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent A  Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

(2012) N. Bien-Ly et al.   JOURNAL OF NEUROSCIENCE

Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

(2012) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

34 Cognitive reserve and survival

(2012) François R. Herrmann   NEUROBIOLOGY OF AGING

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

(2012) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

A large study reveals no association between APOE and Parkinson's disease

(2012) Monica Federoff et al.   NEUROBIOLOGY OF DISEASE

Age-related differences in memory and executive functions in healthy APOE ɛ4 carriers: The contribution of individual differences in prefrontal volumes and systolic blood pressure

(2012) Andrew R. Bender et al.   NEUROPSYCHOLOGIA

Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: A meta-analysis

(2012) Yan-Wei Yin et al.   NEUROSCIENCE LETTERS

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease

(2012) C. Frieden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Association and Expression Analyses With Single-Nucleotide Polymorphisms in TOMM40 in Alzheimer Disease

(2011) Carlos Cruchaga   ARCHIVES OF NEUROLOGY

The APOE Gene Locus in Frontotemporal Dementia and Primary Progressive Aphasia

(2011) Davide Seripa et al.   ARCHIVES OF NEUROLOGY

Effect of APOE ε4 Status on Intrinsic Network Connectivity in Cognitively Normal Elderly Subjects

(2011) Mary M. Machulda   ARCHIVES OF NEUROLOGY

Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

(2011) C Dirk Keene et al.   CURRENT OPINION IN NEUROBIOLOGY

ApoE is required for maintenance of the dentate gyrus neural progenitor pool

(2011) C.-P. Yang et al.   DEVELOPMENT

Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

(2011) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predictive value of APOE- 4 allele for progression from MCI to AD-type dementia: a meta-analysis

(2011) L. S. Elias-Sonnenschein et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-  Amyloidosis

(2011) J. Kim et al.   JOURNAL OF NEUROSCIENCE

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults

(2011) D. Putcha et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study

(2011) Alessandro Biffi et al.   LANCET NEUROLOGY

Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

(2011) Henryk Barthel et al.   LANCET NEUROLOGY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging

(2011) V. B. Gupta et al.   NEUROLOGY

Longitudinal modeling of frontal cognition in APOE  4 homozygotes, heterozygotes, and noncarriers

(2011) R. J. Caselli et al.   NEUROLOGY

The Association of APOE Genotype with Cognitive Function in Persons Aged 35 Years or Older

(2011) Gerbrand J. Izaks et al.   PLoS One

Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

(2011) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Influence of apolipoprotein E ɛ4 on rates of cognitive and functional decline in mild cognitive impairment

(2010) Danielle C. Whitehair et al.   Alzheimers & Dementia

Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice

(2010) Manuel Buttini et al.   AMERICAN JOURNAL OF PATHOLOGY

Variants at APOE influence risk of deep and lobar intracerebral hemorrhage

(2010) Alessandro Biffi et al.   ANNALS OF NEUROLOGY

New Perspectives on Amyloid-β Dynamics After Acute Brain Injury

(2010) Sandra Magnoni et al.   ARCHIVES OF NEUROLOGY

Does apolipoprotein E genotype modify the clinical expression of ALS?

(2010) A. Jawaid et al.   EUROPEAN JOURNAL OF NEUROLOGY

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early-Onset Form (Type I) and Demyelination in Late-Onset Form (Type II)

(2010) Lars Svennerholm et al.   JOURNAL OF NEUROCHEMISTRY

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF A 42

(2010) Y. I. Sheline et al.   JOURNAL OF NEUROSCIENCE

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

(2010) J. L. O'Brien et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2

(2010) R.C. Klein et al.   NEUROSCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

(2010) Yadong Huang   TRENDS IN MOLECULAR MEDICINE

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment

(2009) Judy Pa et al.   ANNALS OF NEUROLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

(2009) S. B. Dumanis et al.   JOURNAL OF NEUROSCIENCE

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

(2009) P.M. Sullivan et al.   NEUROBIOLOGY OF AGING

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

APOE  2 is associated with intact cognition but increased Alzheimer pathology in the oldest old

(2009) D. J. Berlau et al.   NEUROLOGY

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect

(2009) Richard J. Caselli et al.   NEW ENGLAND JOURNAL OF MEDICINE

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

(2009) A D Roses et al.   PHARMACOGENOMICS JOURNAL

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

(2008) Fumiko Irie et al.   ARCHIVES OF NEUROLOGY

Decreased Cognition in Children with Risk Factors for Alzheimer's Disease

(2008) Cinnamon S. Bloss et al.   BIOLOGICAL PSYCHIATRY

The Association between APOE Genotype and Memory Dysfunction in Subjects with Mild Cognitive Impairment Is Related to Age and Alzheimer Pathology

(2008) I.H.G.B. Ramakers et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure

(2008) Ning Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE

Meta-Analysis of APOE4 Allele and Outcome after Traumatic Brain Injury

(2008) Weidong Zhou et al.   JOURNAL OF NEUROTRAUMA

Magnetic Resonance Imaging Characterization of Brain Structure and Function in Mild Cognitive Impairment: A Review

(2008) Michele L. Ries et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Morphologic diagnosis of “vascular dementia” — A critical update

(2008) Kurt A. Jellinger   JOURNAL OF THE NEUROLOGICAL SCIENCES

APOE  4 allele predicts faster cognitive decline in mild Alzheimer disease

(2008) S. Cosentino et al.   NEUROLOGY

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Lack of association of APOE and tau polymorphisms with dementia in Parkinson’s disease

(2008) Mario Ezquerra et al.   NEUROSCIENCE LETTERS

Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E ɛ4

(2006) Thomas Espeseth et al.   NEUROBIOLOGY OF AGING