Article
Environmental Sciences
Zhihui Tian, Haohao Liu, Xinghai Chen, Michael D. Losiewicz, Rui Wang, Xingde Du, Bingqian Wang, Ya Ma, Shiyu Zhang, Linjia Shi, Xing Guo, Yongshui Wang, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang
Summary: The study revealed that oxidative stress induced by MC-LR can activate the DNA damage-mediated ATM/p53 signaling pathway to induce autophagy in male germ cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Yuqin Zhao, Shuailin Hao, Wenchi Wu, Youhang Li, Kaiping Hou, Yu Liu, Wei Cui, Xingzhi Xu, Hailong Wang
Summary: Lysine crotonylation is a reversible protein posttranslational modification that plays a crucial role in maintaining genome stability and responding to genotoxic stresses. It connects cellular metabolism with gene regulation and is involved in various cellular processes, including transcriptional repression induced by double-strand breaks, DNA repair, and the response to DNA replication stress.
Article
Cell Biology
Aracelly Gaete-Argel, Felipe Velasquez, Chantal L. Marquez, Barbara Rojas-Araya, Constanza Bueno-Nieto, Josefina Marin-Rojas, Miguel Cuevas-Zuniga, Ricardo Soto-Rifo, Fernando Valiente-Echeverria
Summary: Tellurium oxyanion, tellurite, is a highly toxic compound that has been increasingly present in the environment due to industrial processes, and is associated with adverse effects on human health. Research shows that tellurite can induce the assembly of stress granules (SGs) in cells, both in the cytoplasm and nucleus. The presence of tellurite-induced nuclear SGs correlates with DNA damage, revealing a new aspect of cellular stress response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanmei Li, Dan Hao, Danfeng Wei, Yue Xiao, Lian Liu, Xiaoxue Li, Lian Wang, Yu Gan, Wei Yan, Bowen Ke, Xian Jiang
Summary: This study investigated the photoprotective effects of CBD against UVB-induced skin damage. The results showed that CBD alleviated cytotoxicity, apoptosis, and cell cycle arrest caused by UVB. CBD also decreased the production of reactive oxygen species and modulated the expression of antioxidant-related proteins. Additionally, CBD mitigated UVB-induced cytotoxicity by activating autophagy. The study also demonstrated that a cream containing 5% CBD was effective in reducing photodamage in a murine model.
Review
Biochemistry & Molecular Biology
Moussa Omorou, Yiwei Huang, Meng Gao, Chenxi Mu, Weijing Xu, Yuchun Han, Hui Xu
Summary: Forkhead box O3 (FOXO3) is a protein encoded by the FOXO3 gene expressed throughout the body and could play a crucial role in longevity and various pathologies. This study comprehensively reviews the expression of FOXO3 under ischemia and reperfusion (IR) conditions and its molecular mechanisms. The expression level of FOXO3 is tissue-specific, with increased expression in lung and intestinal epithelial cells after IR but downregulation in the kidney after IR and skeletal muscles following ischemia. FOXO3 expression in the brain, liver, and heart following IR can be both increased and decreased, contributing to ischemia and reperfusion injury. Controlling FOXO3 expression genetically or pharmacologically may help prevent or treat IR damage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaochen Xie, Ye Zhang, Zhuo Wang, Shanshan Wang, Xiaoyou Jiang, Hongyan Cui, Tingting Zhou, Zheng He, Hao Feng, Qiqiang Guo, Xiaoyu Song, Liu Cao
Summary: ROS, initially considered pathological, are now recognized as signaling intermediates that promote cellular adaptation to stress through autophagy regulation. ATM protein, activated by ROS, is involved in autophagy regulation, maintaining genome stability and triggering cytoplasmic autophagy as a ROS sensor.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Ana Mesquita, James Glenn, Andreas Jenny
Summary: Autophagy is a major catabolic pathway crucial for cellular homeostasis and stress response. Endosomal microautophagy can be induced under stress conditions and regulated by various signaling pathways, suggesting its important role in disease prevention.
Article
Biochemistry & Molecular Biology
Ting-Yu Chen, Bu-Miin Huang, Tang K. Tang, Yu-Ying Chao, Xiao-Yi Xiao, Pei-Rong Lee, Li-Yun Yang, Chia-Yih Wang
Summary: The DNA-PK-p53 cascade induces primary cilia formation under genotoxic stress, contributing to the DNA damage response, while lack of this pathway decreases genotoxic stress-induced ciliogenesis. Besides, ciliogenesis is regulated not only by DNA-PK, but also by autophagy.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Pharmacology & Pharmacy
Olakkaran Shilpa, Kizhakke Purayil Anupama, Anet Antony, Hunasanahally Puttaswamygowda Gurushankara
Summary: The study suggests that Pb accumulation in Drosophila brains induces oxidative stress, leading to DNA damage, apoptosis, and vacuolation.
Article
Gastroenterology & Hepatology
Laura Elisa Buitrago-Molina, Silke Marhenke, Diana Becker, Robert Geffers, Timo Itzel, Andreas Teufel, Hartmut Jaeschke, Andre Lechel, Kristian Unger, Jovana Markovic, Amar Deep Sharma, Jens U. Marquardt, Michael Saborowski, Anna Saborowski, Arndt Vogel
Summary: The study found that loss of p53 in a model of metabolic liver injury impairs the oxidative stress response, aggravates liver damage, and shows a complex interdependency between p21 and p53.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valentine Lagage, Victor Chen, Stephan Uphoff
Summary: Understanding the interplay between phenotypic and genetic adaptation is a focus of evolutionary biology. In this study, we found that the dynamics of stress response can affect the timing of genetic adaptation to oxidative stress in bacteria. By developing new microscopy methods, we revealed how these mutation dynamics arise from phenotypic adaptation mechanisms. Additionally, we discovered that mutation bursts are a general phenomenon associated with adaptation delays.
Article
Environmental Sciences
Lucia M. Odetti, Evelyn C. Lopez Gonzalez, Pablo A. Siroski, Ma. Fernanda Simoniello, Gisela L. Poletta
Summary: This study aimed to assess the molecular stress responses in blood of Caiman latirostris hatchlings exposed to pesticide formulations and found that the expression levels of catalase (cat), superoxide dismutase (sod), and heat shock protein 70 (hsp70) genes were altered, which were associated with oxidative damage and genotoxicity. The pesticides tested showed significant increase in DNA damage and micronucleus frequency, as well as oxidation. The expression levels of cat gene were significantly higher in the cypermethrin group, while the expression of hsp70 gene was significantly lower in glyphosate, cypermethrin, and the ternary mixture group compared to the negative control group.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Microbiology
Jiyeun Park, Hyun-Hee Lee, Heeji Moon, Nahyun Lee, Sieun Kim, Jung-Eun Kim, Yoonji Lee, Kyunghun Min, Hun Kim, Gyung Ja Choi, Yin-Won Lee, Young-Su Seo, Hokyoung Son
Summary: In this study, we investigated the mechanisms responsible for resistance to oxidative stress in plant pathogenic fungi. The transcriptomes of six strains were analyzed, and pathways related to oxidative stress responses were identified. Key genes involved in these pathways were also studied, revealing their roles in oxidative stress response and pathogenicity. This study provides insights into the adaptive mechanisms of plant pathogenic fungi to cope with oxidative stress.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Jiyeun Park, Hyun-Hee Lee, Heeji Moon, Nahyun Lee, Sieun Kim, Jung-Eun Kim, Yoonji Lee, Kyunghun Min, Hun Kim, Gyung Ja Choi, Yin-Won Lee, Young-Su Seo, Hokyoung Son
Summary: In this study, the mechanisms responsible for resistance to oxidative stress in the plant pathogenic fungus Fusarium graminearum were investigated. Weighted gene co-expression network analysis identified several pathways related to oxidative stress responses. Phenotypic characterization of mutants revealed the roles of specific genes in oxidative stress response and pathogenicity. This study advances our understanding of the adaptive mechanisms to cope with oxidative stress in plant pathogenic fungi.
MICROBIOLOGY SPECTRUM
(2023)
Article
Toxicology
Li Zhou, Yonglong Han, Quanjun Yang, Bo Xin, Mengyi Chi, Yan Huo, Cheng Guo, Xipeng Sun
Summary: This study investigated the toxicity of doxorubicin (DOX) on cardiomyocytes, cardiac fibroblasts, and endothelial cells. It was found that DOX had a greater killing effect on cardiomyocytes compared to the other cell types. Additionally, the protective effects of scutellarin (SCU) on DOX-induced cytotoxicity were explored, showing that SCU attenuated oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis, and autophagy induced by DOX.
TOXICOLOGY IN VITRO
(2022)
Article
Biochemical Research Methods
Gianluca Paredi, Federica Mori, Maria Giovanna de Marino, Samanta Raboni, Laura Marchi, Serena Galati, Annamaria Buschini, Domenico Pietro Lo Fiego, Andrea Mozzarelli
JOURNAL OF PROTEOMICS
(2019)
Article
Biochemistry & Molecular Biology
Luisa Tomasello, Marzia Vezzalini, Christian Boni, Massimiliano Bonifacio, Luigi Scaffidi, Mohamed Yassin, Nader Al-Dewik, Paul Takam Kamga, Mauro Krampera, Claudio Sorio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Anesthesiology
Lonnie Moller Johansen, Maria Carla Gerra, Lars Arendt-Nielsen
Summary: Research has found correlations between pain and DNA methylation, but there is currently no established timeframe for the DNA methylation response to pain. Studies highlight variations in DNA methylation time course across different types of pain and species, indicating a need for further investigation in this area.
EUROPEAN JOURNAL OF PAIN
(2021)
Review
Oncology
Christian Boni, Claudio Sorio
Summary: This review highlights the impact of BCR-ABL1 fusion protein on key cellular behaviors in chronic myeloid leukemia, focusing on the interactions between protein phosphatases and protein kinases. It discusses the role of protein phosphatases in disease progression, regulation of leukemic stem cells, and TKI resistance.
Article
Clinical Neurology
Paolo Ossola, Maria Carla Gerra, Maria Lidia Gerra, Giulia Milano, Marta Zatti, Valeria Zavan, Riccardo Volpi, Carlo Marchesi, Claudia Donnini, Gilberto Gerra, Cristiana Di Gennaro
Summary: The pathogenesis of Alcohol Use Disorder is influenced by both genetic and early environmental factors. Gender, psychopathology symptoms, and certain genetic polymorphisms play a role in moderating this association. Prevention strategies focused on creating a caring environment, psychoeducation, and avoiding self-medication could improve outcomes for individuals at higher risk, particularly males.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Genetics & Heredity
Maria Carla Gerra, Cristina Dallabona, Lars Arendt-Nielsen
Summary: Prescription opioids are commonly used for chronic pain conditions, but long-term therapy can lead to risks of addiction and overdose. Studies have shown that opioid addiction and chronic pain conditions involve genetic and epigenetic alterations, but the contribution and mechanisms are not fully understood.
Article
Medicine, General & Internal
Maria Carla Gerra, Davide Carnevali, Paolo Ossola, Alberto Gonzalez-Villar, Inge Sokilde Pedersen, Yolanda Trinanes, Claudia Donnini, Matteo Manfredini, Lars Arendt-Nielsen, Maria Teresa Carrillo-de-la-Pena
Summary: This study explores DNA methylation differences in FM patients and healthy controls, identifying significant variations in the GCSAML region. The study also reveals distinct network structures of DNA methylation sites between the two groups, with the GRM2 region playing a central role in FM patients. Logistic regression analysis highlights the association between depressive symptoms, DNA methylation in the GRM2 region, and the risk of FM.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Christian Boni, Claudio Sorio
Summary: Protein tyrosine phosphatase gamma (PTPRG) is a tumor suppressor gene that is associated with various human cancers. Its inactivation or loss is common in different tumors and plays a crucial role in the central nervous system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Christian Boni, Carlo Laudanna, Claudio Sorio
Summary: Protein tyrosine phosphatase receptor gamma (PTPRG) interacts with and regulates several tyrosine kinases, playing a tumor suppressor role in various cancers. It is widely expressed in human tissues and may serve as a regulatory switch in cell signaling processes, particularly in the vascular and renal tissues as a [HCO3-] sensor. It has potential interactions with the contactins family.
Article
Biochemistry & Molecular Biology
Giulia Lombardi, Roberta Valeria Latorre, Alessandro Mosca, Diego Calvanese, Luisa Tomasello, Christian Boni, Manuela Ferracin, Massimo Negrini, Nader Al Dewik, Mohamed Yassin, Mohamed A. Ismail, Bruno Carpentieri, Claudio Sorio, Paola Lecca
Summary: This study analyzed the modulation of the K562 transcriptome in the context of Chronic Myeloid Leukemia (CML) using the tumor suppressor gene PTPRG and the tyrosine kinase inhibitor Imatinib. The analysis identified genes whose expression levels were altered by PTPRG and Imatinib, providing insights into the transcriptomic landscape of CML. Two different methods were used in the analysis, with one focusing on gene set enrichment analysis and the identification of transcription factors, and the other focusing on selecting transcription factors from differentially expressed genes. The study revealed the potential upregulation of RARG and CD36 genes by PTPRG, suggesting a role in cell differentiation. The findings provide new insights into the molecular mechanisms of tumor suppression in the context of CML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Maria Carla Gerra, Davide Carnevali, Inge Sokilde Pedersen, Claudia Donnini, Matteo Manfredini, Alberto Gonzalez-Villar, Yolanda Trinanes, Marina Pidal-Miranda, Lars Arendt-Nielsen, Maria Teresa Carrillo-de-la-Pena
Summary: This pilot study investigated DNA methylation changes of genes related to fibromyalgia (FM) development and comorbid symptoms in leukocytes. Results showed the involvement of the glutamate pathway in FM and the combined effect of methylated and unmethylated genes as risk factors. Further research on identified biomarkers could lead to improved diagnosis and effective therapies for FM.
SCANDINAVIAN JOURNAL OF PAIN
(2021)
Meeting Abstract
Hematology
Mohammad Abdul-Jaber Abdulla, Prem Chandra, Susana El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed A. Yassin
Review
Neurosciences
Simona D'Agnelli, Maria C. Gerra, Elena Bignami, Lars Arendt-Nielsen
Article
Rheumatology
M. C. Gerra, A. Gonzalez-Villar, L. Arendt-Nielsen, I. Sokilde Pedersen, Y. Trinanes, C. Donnini, M. Manfredini, D. Walther, G. L. Moeller, M. Pidal-Miranda, S. Romero-Yuste, M. Arias-Gomez, M. T. Carrillo-de-la-Pena
Summary: While no significant genetic associations were found between FM patients and their healthy relatives using family-based analysis or SNP combination tests, a potential genetic marker associated with depression was identified in the subgroup analysis of FM patients, indicating that FM is not a homogeneous disorder.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)