Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex

Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer’s disease model

(2018) Fernando Goñi et al.   Alzheimers Research & Therapy

Hippocampal Proteomic Analysis Reveals Distinct Pathway Deregulation Profiles at Early and Late Stages in a Rat Model of Alzheimer’s-Like Amyloid Pathology

(2017) Sonia Do Carmo et al.   MOLECULAR NEUROBIOLOGY

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

(2017) Reisuke H. Takahashi et al.   PATHOLOGY INTERNATIONAL

A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment

(2017) Wanda Carolina Leon et al.   JOURNAL OF ALZHEIMERS DISEASE

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

(2016) David J. Koss et al.   ACTA NEUROPATHOLOGICA

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease

(2016) Pamela V Martino Adami et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls

(2016) Armand Savioz et al.   Neurodegenerative Diseases

Genetic Modulation of Soluble A  Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

(2014) S. W. Fowler et al.   JOURNAL OF NEUROSCIENCE

Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease

(2014) Cecilia E. Hanzel et al.   NEUROBIOLOGY OF AGING

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

(2014) M Florencia Iulita et al.   Acta Neuropathologica Communications

Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

(2014) Yingjie Qi et al.   Acta Neuropathologica Communications

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

(2012) Daniela Kaden et al.   EMBO Molecular Medicine

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

(2012) Maria Teresa Ferretti et al.   Journal of Neuroinflammation

Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular Aβ

(2012) Gunnar K. Gouras et al.   LIFE SCIENCES

Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models

(2012) A. Claudio Cuello et al.   LIFE SCIENCES

High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils

(2011) Estibaliz Capetillo-Zarate et al.   AMERICAN JOURNAL OF PATHOLOGY

Transgenic Mice as a Model of Pre-Clinical Alzheimers Disease

(2011) M. T. Ferretti et al.   Current Alzheimer Research

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Loss and reorganization of calretinin-containing interneurons in the epileptic human hippocampus

(2010) K. Toth et al.   BRAIN

A guide to super-resolution fluorescence microscopy

(2010) Lothar Schermelleh et al.   JOURNAL OF CELL BIOLOGY

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease

(2008) Tara L. Spires-Jones et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING