Neurodegenerative processes in Huntington's disease

The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease

(2011) Ignacio Munoz-Sanjuan et al.   JOURNAL OF CLINICAL INVESTIGATION

Ageing, Neuronal Connectivity and Brain Disorders: An Unsolved Ripple Effect

(2011) Daniele Bano et al.   MOLECULAR NEUROBIOLOGY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease

(2011) S Zhu et al.   Cell Death & Disease

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

(2011) R Russo et al.   Cell Death & Disease

Clearance of Mutant Proteins as a Therapeutic Target in Neurodegenerative Diseases

(2010) Dimitri Krainc   ARCHIVES OF NEUROLOGY

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity

(2010) Tjakko J. van Ham et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Negative regulation of autophagy

(2010) C Liang   CELL DEATH AND DIFFERENTIATION

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

(2010) Veronica Costa et al.   EMBO Molecular Medicine

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

(2010) M. A. Pouladi et al.   HUMAN MOLECULAR GENETICS

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

(2010) John P. Miller et al.   NEURON

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

(2010) M L Marino et al.   Cell Death & Disease

Activation of mTOR coincides with autophagy during ligation-induced atrophy in the rat submandibular gland

(2010) N Silver et al.   Cell Death & Disease

Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR

(2010) M V Blagosklonny   Cell Death & Disease

Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)

(2010) J Sassone et al.   Cell Death & Disease

CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival

(2010) J Nicolai et al.   Cell Death & Disease

The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress

(2010) L Deng et al.   Cell Death & Disease

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

(2010) J J Rodríguez et al.   Cell Death & Disease

Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease

(2010) D Ciavardelli et al.   Cell Death & Disease

Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia

(2010) Q Li et al.   Cell Death & Disease

Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy

(2010) R R Ruela-de-Sousa et al.   Cell Death & Disease

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.

(2010) S N Sivananthan et al.   Cell Death & Disease

TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease

(2010) M-H Lee et al.   Cell Death & Disease

Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

(2010) A Ruiz et al.   Cell Death & Disease

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease

(2010) T A Yacoubian et al.   Cell Death & Disease

IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter

(2010) G C Mitchell et al.   Cell Death & Disease

Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells

(2010) H L Bennett et al.   Cell Death & Disease

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy

(2010) N Heidari et al.   Cell Death & Disease

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice

(2010) Shuqiu Zheng et al.   PLoS Genetics

Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos

(2009) Congcong He et al.   Autophagy

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Bif-1/Endophilin B1: a candidate for crescent driving force in autophagy

(2009) Y Takahashi et al.   CELL DEATH AND DIFFERENTIATION

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

The late stages of autophagy: how does the end begin?

(2009) T Noda et al.   CELL DEATH AND DIFFERENTIATION

Vesicular trafficking and autophagosome formation

(2009) A Longatti et al.   CELL DEATH AND DIFFERENTIATION

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

Enhanced α-Synuclein Expression in Human Neurodegenerative Diseases: Pathogenetic and Therapeutic Implications

(2009) Alison McCormack et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

(2009) Ashwani K Thakur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

(2009) V. Wee Yong et al.   NEURON

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Autophagy and cell death in model organisms

(2008) N Kourtis et al.   CELL DEATH AND DIFFERENTIATION

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Autophagy genes and ageing

(2008) T Vellai   CELL DEATH AND DIFFERENTIATION

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Eating the enemy within: autophagy in infectious diseases

(2008) A Orvedahl et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

(2008) Judit Pallos et al.   HUMAN MOLECULAR GENETICS

Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity

(2008) C. M. Cowan et al.   JOURNAL OF NEUROSCIENCE

Expanded-Polyglutamine Huntingtin Protein Suppresses the Secretion and Production of a Chemokine (CCL5/RANTES) by Astrocytes

(2008) S.-Y. Chou et al.   JOURNAL OF NEUROSCIENCE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE

Active Transport of the Ubiquitin Ligase MID1 along the Microtubules Is Regulated by Protein Phosphatase 2A

(2008) Beatriz Aranda-Orgillés et al.   PLoS One

Mitochondrial Ca2+ signalling in hippocampal neurons

(2007) Kenneth W. Young et al.   CELL CALCIUM